FBT2_ARATH
ID FBT2_ARATH Reviewed; 499 AA.
AC Q5FV41; Q84TJ6;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2005, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Probable folate-biopterin transporter 2;
GN OrderedLocusNames=At5g25050; ORFNames=T11H3.60;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY.
RX PubMed=16162503; DOI=10.1074/jbc.m507432200;
RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
RT "Higher plant plastids and cyanobacteria have folate carriers related to
RT those of trypanosomatids.";
RL J. Biol. Chem. 280:38457-38463(2005).
CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
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DR EMBL; AC005964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002688; AED93394.1; -; Genomic_DNA.
DR EMBL; BT005727; AAO64142.1; -; mRNA.
DR EMBL; BT020533; AAW70379.1; -; mRNA.
DR EMBL; AK228683; BAF00588.1; -; mRNA.
DR RefSeq; NP_197887.1; NM_122414.3.
DR AlphaFoldDB; Q5FV41; -.
DR STRING; 3702.AT5G25050.1; -.
DR iPTMnet; Q5FV41; -.
DR PaxDb; Q5FV41; -.
DR PRIDE; Q5FV41; -.
DR ProteomicsDB; 222434; -.
DR EnsemblPlants; AT5G25050.1; AT5G25050.1; AT5G25050.
DR GeneID; 832576; -.
DR Gramene; AT5G25050.1; AT5G25050.1; AT5G25050.
DR KEGG; ath:AT5G25050; -.
DR Araport; AT5G25050; -.
DR TAIR; locus:2179285; AT5G25050.
DR eggNOG; ENOG502QPUV; Eukaryota.
DR HOGENOM; CLU_018563_1_1_1; -.
DR InParanoid; Q5FV41; -.
DR OMA; ARELHWS; -.
DR OrthoDB; 659174at2759; -.
DR PhylomeDB; Q5FV41; -.
DR PRO; PR:Q5FV41; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q5FV41; baseline and differential.
DR Genevisible; Q5FV41; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; PTHR31585; 1.
DR Pfam; PF03092; BT1; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00788; fbt; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..499
FT /note="Probable folate-biopterin transporter 2"
FT /id="PRO_0000420114"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..112
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 116..136
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 185..205
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 330..350
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 354..374
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 399..419
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 457
FT /note="K -> E (in Ref. 3; AAO64142 and 5; BAF00588)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 499 AA; 55465 MW; 0BF5D77C281D9311 CRC64;
MVVEEQSLEN GGSVHVVKGE SNFRNVVCGP VRWLKMLSSE LHWSFVFGVV SLYGINQGLG
GSLGRVATEY YMKDVQKVQP SESQALTAIT KIPWIIKPLW GILTDVLPIF GFHRRPYFIL
AGVLGVVSLL FISLHSNLHL YLALFWMTIS SAAMAIADVT IDACTAYNSI KHPSLASDMQ
SLCSLSSSIG ALLGFFMSGI LVHLVGSKGV FGLLTFPFAL VSVVGIVFSE PHVPGFSYKQ
VNQKFTDAGK AMWRTMKCSD VWRPSLYMYI SLTLGLNIHE GLFYWFTDSK DGPLFAQETV
GFILSIGSIG SILAATLYQL VLKDHPFRGL CLWTQLLFAL SGMLDLILVF RLNLKFGLPD
YLFIVVDEIV SQMIGRLKWM PLLVLTSKLC PHGIEGTFFA LLMSIDNAGL MTSSWLGGIM
LHVLKVTRTE FGNLWLAVLV RNVMRLLPLC FLFLVPKGDQ NTFKLPDEIM GEDSDEEKDE
KEGTRNLELA SLVHSVDRR
