FBT3_ARATH
ID FBT3_ARATH Reviewed; 497 AA.
AC Q9SQN2;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable folate-biopterin transporter 3;
GN OrderedLocusNames=At1g79710; ORFNames=F19K16.31, F20B17.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=16162503; DOI=10.1074/jbc.m507432200;
RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
RT "Higher plant plastids and cyanobacteria have folate carriers related to
RT those of trypanosomatids.";
RL J. Biol. Chem. 280:38457-38463(2005).
CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
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DR EMBL; AC010793; AAF68109.1; -; Genomic_DNA.
DR EMBL; AC011717; AAG52252.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE36290.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60453.1; -; Genomic_DNA.
DR PIR; A96828; A96828.
DR RefSeq; NP_001322738.1; NM_001334915.1.
DR RefSeq; NP_178089.1; NM_106620.4.
DR AlphaFoldDB; Q9SQN2; -.
DR SMR; Q9SQN2; -.
DR PaxDb; Q9SQN2; -.
DR PRIDE; Q9SQN2; -.
DR ProteomicsDB; 222435; -.
DR EnsemblPlants; AT1G79710.1; AT1G79710.1; AT1G79710.
DR EnsemblPlants; AT1G79710.2; AT1G79710.2; AT1G79710.
DR GeneID; 844310; -.
DR Gramene; AT1G79710.1; AT1G79710.1; AT1G79710.
DR Gramene; AT1G79710.2; AT1G79710.2; AT1G79710.
DR KEGG; ath:AT1G79710; -.
DR Araport; AT1G79710; -.
DR TAIR; locus:2017814; AT1G79710.
DR eggNOG; ENOG502QPUV; Eukaryota.
DR HOGENOM; CLU_018563_1_1_1; -.
DR InParanoid; Q9SQN2; -.
DR OMA; VSTQYYM; -.
DR OrthoDB; 659174at2759; -.
DR PhylomeDB; Q9SQN2; -.
DR PRO; PR:Q9SQN2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SQN2; baseline and differential.
DR Genevisible; Q9SQN2; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; PTHR31585; 1.
DR Pfam; PF03092; BT1; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00788; fbt; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..497
FT /note="Probable folate-biopterin transporter 3"
FT /id="PRO_0000420115"
FT TRANSMEM 40..60
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 186..206
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 212..232
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 405..425
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 439..459
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 497 AA; 55028 MW; 355EEE2CF20C0F97 CRC64;
MANRSEEAEY ENDSRRNHQD KKKEGVLDLV LKRPLRWLRM LIEELHWSFF FGVIIVYGVS
QGLGKGLSKV STQYYFKDEQ KIQPSQAQIY VGLIQIPWII KPLWGLLTDV VPVLGYRRRP
YFILAGFLAM ISMMVLWLHT NLHLALALSC LVAGSAGVAI ADVTIDACVT QCSISHPTLA
ADMQSLCGLC SSIGSLVGFS LSGVLVHLVG SKGVYGLLGV TAGLLVVVGM VLKESPSRSL
GRKHVNDKFL DAGSAIWKTF QYGEVWRPCL FMLLSAAVSL HIHEGMFYWY TDSKDGPSFS
KEAVGSIMSF GAIGSLVGIL LYQNFLKNFP FRNVVFWALS LSVLSGFLDL ILVLRINLKL
GLPDYFFIVV DEFVSHMISR IKWLPLLVLS SKLCPAGMEG TFFALLMSIE HIGHLVSSWG
GGVLLHALKV TRTQFDNLWL VIVIRSLLRV IPIGLVFLIP NVDSNSTILP AEMLTSRISE
GVDTEKIEMT ALISDEA
