FBT4_ARATH
ID FBT4_ARATH Reviewed; 491 AA.
AC Q8RWQ5; Q9FFU4;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Probable folate-biopterin transporter 4;
GN OrderedLocusNames=At5g54860; ORFNames=MBG8.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9330910; DOI=10.1093/dnares/4.3.215;
RA Sato S., Kotani H., Nakamura Y., Kaneko T., Asamizu E., Fukami M.,
RA Miyajima N., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. I. Sequence
RT features of the 1.6 Mb regions covered by twenty physically assigned P1
RT clones.";
RL DNA Res. 4:215-230(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=16162503; DOI=10.1074/jbc.m507432200;
RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
RT "Higher plant plastids and cyanobacteria have folate carriers related to
RT those of trypanosomatids.";
RL J. Biol. Chem. 280:38457-38463(2005).
CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB08765.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB005232; BAB08765.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96550.1; -; Genomic_DNA.
DR EMBL; AY091775; AAM10323.1; -; mRNA.
DR RefSeq; NP_200297.2; NM_124868.5.
DR AlphaFoldDB; Q8RWQ5; -.
DR STRING; 3702.AT5G54860.1; -.
DR PaxDb; Q8RWQ5; -.
DR PRIDE; Q8RWQ5; -.
DR ProteomicsDB; 230831; -.
DR EnsemblPlants; AT5G54860.1; AT5G54860.1; AT5G54860.
DR GeneID; 835577; -.
DR Gramene; AT5G54860.1; AT5G54860.1; AT5G54860.
DR KEGG; ath:AT5G54860; -.
DR Araport; AT5G54860; -.
DR TAIR; locus:2160150; AT5G54860.
DR eggNOG; ENOG502QPYM; Eukaryota.
DR HOGENOM; CLU_018563_0_1_1; -.
DR InParanoid; Q8RWQ5; -.
DR OMA; IMVLCGS; -.
DR OrthoDB; 709372at2759; -.
DR PhylomeDB; Q8RWQ5; -.
DR PRO; PR:Q8RWQ5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8RWQ5; baseline and differential.
DR Genevisible; Q8RWQ5; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; PTHR31585; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00788; fbt; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..491
FT /note="Probable folate-biopterin transporter 4"
FT /id="PRO_0000420116"
FT TRANSMEM 14..34
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..72
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 154..174
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 389..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 222..262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 53883 MW; C919399DFACD6909 CRC64;
MIHWLKQLRS AFGVAFLWLV CLIYFTQGFR SFVWTAVSYQ LKDRLQLSPS ASQFVFSVAF
FPWSIKPLYG IISDCIPIGG KKRTPYLVIS TVLSLVPWLV LGLDSTSRSS SLYLMIFLTV
QNLGSAMADV VIDAMIAEAV RLEKASFAGD LQSVSWFAMA VGGVCGSLLG GYALSNLKIE
TIFLLFTVLP ALQLLSCALV EESPANNEPL PELLDSNEFE EKSLTSNDNY PDTSKSNTRR
RKGQKKGKKG DSNGKSETQK KQSKSLASQW FQSLKAATFG LGRAFKQPII LRPMAWFFIA
HITVPNLSTV MFYYQTEVLQ LDAAFLGTAR VVGWLGLMFG TFIYNRYLQD MTLRKSLLFA
HIGLSVTILL DMVLVSRANV GYGVSDKTMV LFGSALGDAI NQLKFMPFLI LSGRLCPPGI
EGTLFALFMS INNLGNTVGS FMGAGLASLL GISSGSFDNM FMGLAIQVFC TYIPVLFLFL
IPKEATGVSA S
