AIM4_YEAST
ID AIM4_YEAST Reviewed; 123 AA.
AC P38305; D6VQI8;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1994, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Altered inheritance of mitochondria protein 4;
DE AltName: Full=Synthetic with old yellow enzyme protein 1;
GN Name=AIM4; Synonyms=SOY1; OrderedLocusNames=YBR194W; ORFNames=YBR1404;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8346681; DOI=10.1002/yea.320090611;
RA Demolis N., Mallet L., Bussereau F., Jacquet M.;
RT "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces
RT cerevisiae chromosome II, which also contains the putative ribosomal gene
RT L21 and a new putative essential gene with a leucine zipper motif.";
RL Yeast 9:645-659(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA Mewes H.-W., Kleine K.;
RT "Complete DNA sequence of yeast chromosome II.";
RL EMBO J. 13:5795-5809(1994).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [5]
RP ASSOCIATION WITH THE NUCLEAR PORE COMPLEX, IDENTIFICATION BY MASS
RP SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX PubMed=10684247; DOI=10.1083/jcb.148.4.635;
RA Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.;
RT "The yeast nuclear pore complex: composition, architecture, and transport
RT mechanism.";
RL J. Cell Biol. 148:635-651(2000).
RN [6]
RP DISRUPTION PHENOTYPE.
RX PubMed=16989656; DOI=10.1111/j.1567-1364.2006.00162.x;
RA Ando A., Nakamura T., Murata Y., Takagi H., Shima J.;
RT "Identification and classification of genes required for tolerance to
RT freeze-thaw stress revealed by genome-wide screening of Saccharomyces
RT cerevisiae deletion strains.";
RL FEMS Yeast Res. 7:244-253(2007).
RN [7]
RP DISRUPTION PHENOTYPE.
RX PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA Troyanskaya O.G., Caudy A.A.;
RT "Computationally driven, quantitative experiments discover genes required
RT for mitochondrial biogenesis.";
RL PLoS Genet. 5:E1000407-E1000407(2009).
RN [8]
RP DISRUPTION PHENOTYPE.
RX PubMed=20210661; DOI=10.1089/omi.2009.0149;
RA Teixeira M.C., Raposo L.R., Palma M., Sa-Correia I.;
RT "Identification of genes required for maximal tolerance to high-glucose
RT concentrations, as those present in industrial alcoholic fermentation
RT media, through a chemogenomics approach.";
RL OMICS 14:201-210(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC -!- SUBUNIT: May interact with the nuclear pore complex.
CC -!- INTERACTION:
CC P38305; Q06525: URN1; NbExp=6; IntAct=EBI-20939, EBI-35138;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10684247}.
CC -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss
CC and sensitivity to freeze-thaw stress and high concentrations of
CC glucose. {ECO:0000269|PubMed:16989656, ECO:0000269|PubMed:19300474,
CC ECO:0000269|PubMed:20210661}.
CC -!- SIMILARITY: Belongs to the AIM4 family. {ECO:0000305}.
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DR EMBL; Z21487; CAA79681.1; -; Genomic_DNA.
DR EMBL; Z36063; CAA85156.1; -; Genomic_DNA.
DR EMBL; AY692669; AAT92688.1; -; Genomic_DNA.
DR EMBL; BK006936; DAA07308.1; -; Genomic_DNA.
DR PIR; S34019; S34019.
DR RefSeq; NP_009753.3; NM_001178542.3.
DR AlphaFoldDB; P38305; -.
DR BioGRID; 32891; 554.
DR DIP; DIP-2018N; -.
DR IntAct; P38305; 67.
DR MINT; P38305; -.
DR STRING; 4932.YBR194W; -.
DR MaxQB; P38305; -.
DR PaxDb; P38305; -.
DR PRIDE; P38305; -.
DR EnsemblFungi; YBR194W_mRNA; YBR194W; YBR194W.
DR GeneID; 852493; -.
DR KEGG; sce:YBR194W; -.
DR SGD; S000000398; AIM4.
DR VEuPathDB; FungiDB:YBR194W; -.
DR eggNOG; ENOG502SDQZ; Eukaryota.
DR HOGENOM; CLU_2016514_0_0_1; -.
DR InParanoid; P38305; -.
DR OMA; QEDSAYM; -.
DR BioCyc; YEAST:G3O-29136-MON; -.
DR PRO; PR:P38305; -.
DR Proteomes; UP000002311; Chromosome II.
DR RNAct; P38305; protein.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..123
FT /note="Altered inheritance of mitochondria protein 4"
FT /id="PRO_0000202507"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 123 AA; 14234 MW; AF25FE81D22D4C8C CRC64;
MDQKKDPSNN LTERRVSKVQ RPNKKKVRNQ VESLSRNLER NKEGQLLQTV SKGHLEADSG
HSLGREKENG ELGIRSIFYD KDWNPRGTAP SHYRNIPYNP ATFKRRTEVQ ARLGNLENIK
IPK