位置:首页 > 蛋白库 > AIM4_YEAST
AIM4_YEAST
ID   AIM4_YEAST              Reviewed;         123 AA.
AC   P38305; D6VQI8;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Altered inheritance of mitochondria protein 4;
DE   AltName: Full=Synthetic with old yellow enzyme protein 1;
GN   Name=AIM4; Synonyms=SOY1; OrderedLocusNames=YBR194W; ORFNames=YBR1404;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8346681; DOI=10.1002/yea.320090611;
RA   Demolis N., Mallet L., Bussereau F., Jacquet M.;
RT   "RIM2, MSI1 and PGI1 are located within an 8 kb segment of Saccharomyces
RT   cerevisiae chromosome II, which also contains the putative ribosomal gene
RT   L21 and a new putative essential gene with a leucine zipper motif.";
RL   Yeast 9:645-659(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=7813418; DOI=10.1002/j.1460-2075.1994.tb06923.x;
RA   Feldmann H., Aigle M., Aljinovic G., Andre B., Baclet M.C., Barthe C.,
RA   Baur A., Becam A.-M., Biteau N., Boles E., Brandt T., Brendel M.,
RA   Brueckner M., Bussereau F., Christiansen C., Contreras R., Crouzet M.,
RA   Cziepluch C., Demolis N., Delaveau T., Doignon F., Domdey H.,
RA   Duesterhus S., Dubois E., Dujon B., El Bakkoury M., Entian K.-D.,
RA   Feuermann M., Fiers W., Fobo G.M., Fritz C., Gassenhuber J., Glansdorff N.,
RA   Goffeau A., Grivell L.A., de Haan M., Hein C., Herbert C.J.,
RA   Hollenberg C.P., Holmstroem K., Jacq C., Jacquet M., Jauniaux J.-C.,
RA   Jonniaux J.-L., Kallesoee T., Kiesau P., Kirchrath L., Koetter P.,
RA   Korol S., Liebl S., Logghe M., Lohan A.J.E., Louis E.J., Li Z.Y.,
RA   Maat M.J., Mallet L., Mannhaupt G., Messenguy F., Miosga T., Molemans F.,
RA   Mueller S., Nasr F., Obermaier B., Perea J., Pierard A., Piravandi E.,
RA   Pohl F.M., Pohl T.M., Potier S., Proft M., Purnelle B., Ramezani Rad M.,
RA   Rieger M., Rose M., Schaaff-Gerstenschlaeger I., Scherens B.,
RA   Schwarzlose C., Skala J., Slonimski P.P., Smits P.H.M., Souciet J.-L.,
RA   Steensma H.Y., Stucka R., Urrestarazu L.A., van der Aart Q.J.M.,
RA   Van Dyck L., Vassarotti A., Vetter I., Vierendeels F., Vissers S.,
RA   Wagner G., de Wergifosse P., Wolfe K.H., Zagulski M., Zimmermann F.K.,
RA   Mewes H.-W., Kleine K.;
RT   "Complete DNA sequence of yeast chromosome II.";
RL   EMBO J. 13:5795-5809(1994).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [5]
RP   ASSOCIATION WITH THE NUCLEAR PORE COMPLEX, IDENTIFICATION BY MASS
RP   SPECTROMETRY, AND SUBCELLULAR LOCATION.
RX   PubMed=10684247; DOI=10.1083/jcb.148.4.635;
RA   Rout M.P., Aitchison J.D., Suprapto A., Hjertaas K., Zhao Y., Chait B.T.;
RT   "The yeast nuclear pore complex: composition, architecture, and transport
RT   mechanism.";
RL   J. Cell Biol. 148:635-651(2000).
RN   [6]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16989656; DOI=10.1111/j.1567-1364.2006.00162.x;
RA   Ando A., Nakamura T., Murata Y., Takagi H., Shima J.;
RT   "Identification and classification of genes required for tolerance to
RT   freeze-thaw stress revealed by genome-wide screening of Saccharomyces
RT   cerevisiae deletion strains.";
RL   FEMS Yeast Res. 7:244-253(2007).
RN   [7]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=19300474; DOI=10.1371/journal.pgen.1000407;
RA   Hess D.C., Myers C.L., Huttenhower C., Hibbs M.A., Hayes A.P., Paw J.,
RA   Clore J.J., Mendoza R.M., Luis B.S., Nislow C., Giaever G., Costanzo M.,
RA   Troyanskaya O.G., Caudy A.A.;
RT   "Computationally driven, quantitative experiments discover genes required
RT   for mitochondrial biogenesis.";
RL   PLoS Genet. 5:E1000407-E1000407(2009).
RN   [8]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=20210661; DOI=10.1089/omi.2009.0149;
RA   Teixeira M.C., Raposo L.R., Palma M., Sa-Correia I.;
RT   "Identification of genes required for maximal tolerance to high-glucose
RT   concentrations, as those present in industrial alcoholic fermentation
RT   media, through a chemogenomics approach.";
RL   OMICS 14:201-210(2010).
RN   [9]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA   Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA   Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA   Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT   "N-terminal acetylome analyses and functional insights of the N-terminal
RT   acetyltransferase NatB.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
CC   -!- SUBUNIT: May interact with the nuclear pore complex.
CC   -!- INTERACTION:
CC       P38305; Q06525: URN1; NbExp=6; IntAct=EBI-20939, EBI-35138;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10684247}.
CC   -!- DISRUPTION PHENOTYPE: Increases frequency of mitochondrial genome loss
CC       and sensitivity to freeze-thaw stress and high concentrations of
CC       glucose. {ECO:0000269|PubMed:16989656, ECO:0000269|PubMed:19300474,
CC       ECO:0000269|PubMed:20210661}.
CC   -!- SIMILARITY: Belongs to the AIM4 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z21487; CAA79681.1; -; Genomic_DNA.
DR   EMBL; Z36063; CAA85156.1; -; Genomic_DNA.
DR   EMBL; AY692669; AAT92688.1; -; Genomic_DNA.
DR   EMBL; BK006936; DAA07308.1; -; Genomic_DNA.
DR   PIR; S34019; S34019.
DR   RefSeq; NP_009753.3; NM_001178542.3.
DR   AlphaFoldDB; P38305; -.
DR   BioGRID; 32891; 554.
DR   DIP; DIP-2018N; -.
DR   IntAct; P38305; 67.
DR   MINT; P38305; -.
DR   STRING; 4932.YBR194W; -.
DR   MaxQB; P38305; -.
DR   PaxDb; P38305; -.
DR   PRIDE; P38305; -.
DR   EnsemblFungi; YBR194W_mRNA; YBR194W; YBR194W.
DR   GeneID; 852493; -.
DR   KEGG; sce:YBR194W; -.
DR   SGD; S000000398; AIM4.
DR   VEuPathDB; FungiDB:YBR194W; -.
DR   eggNOG; ENOG502SDQZ; Eukaryota.
DR   HOGENOM; CLU_2016514_0_0_1; -.
DR   InParanoid; P38305; -.
DR   OMA; QEDSAYM; -.
DR   BioCyc; YEAST:G3O-29136-MON; -.
DR   PRO; PR:P38305; -.
DR   Proteomes; UP000002311; Chromosome II.
DR   RNAct; P38305; protein.
DR   GO; GO:0005737; C:cytoplasm; IDA:SGD.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..123
FT                   /note="Altered inheritance of mitochondria protein 4"
FT                   /id="PRO_0000202507"
FT   REGION          1..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   123 AA;  14234 MW;  AF25FE81D22D4C8C CRC64;
     MDQKKDPSNN LTERRVSKVQ RPNKKKVRNQ VESLSRNLER NKEGQLLQTV SKGHLEADSG
     HSLGREKENG ELGIRSIFYD KDWNPRGTAP SHYRNIPYNP ATFKRRTEVQ ARLGNLENIK
     IPK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024