FBT6_ARATH
ID FBT6_ARATH Reviewed; 503 AA.
AC Q9LEV7;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Probable folate-biopterin transporter 6;
GN OrderedLocusNames=At5g10820; ORFNames=T30N20_90;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=16162503; DOI=10.1074/jbc.m507432200;
RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
RT "Higher plant plastids and cyanobacteria have folate carriers related to
RT those of trypanosomatids.";
RL J. Biol. Chem. 280:38457-38463(2005).
CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
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DR EMBL; AL365234; CAB96837.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91600.1; -; Genomic_DNA.
DR EMBL; BX830317; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; T50791; T50791.
DR RefSeq; NP_196643.1; NM_121120.4.
DR AlphaFoldDB; Q9LEV7; -.
DR SMR; Q9LEV7; -.
DR BioGRID; 16227; 1.
DR IntAct; Q9LEV7; 1.
DR PaxDb; Q9LEV7; -.
DR PRIDE; Q9LEV7; -.
DR ProteomicsDB; 222436; -.
DR EnsemblPlants; AT5G10820.1; AT5G10820.1; AT5G10820.
DR GeneID; 830949; -.
DR Gramene; AT5G10820.1; AT5G10820.1; AT5G10820.
DR KEGG; ath:AT5G10820; -.
DR Araport; AT5G10820; -.
DR TAIR; locus:2183810; AT5G10820.
DR eggNOG; ENOG502QUG7; Eukaryota.
DR HOGENOM; CLU_018563_1_1_1; -.
DR InParanoid; Q9LEV7; -.
DR OMA; YIPWVMR; -.
DR OrthoDB; 659174at2759; -.
DR PhylomeDB; Q9LEV7; -.
DR PRO; PR:Q9LEV7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9LEV7; baseline and differential.
DR Genevisible; Q9LEV7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; PTHR31585; 1.
DR Pfam; PF03092; BT1; 2.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00788; fbt; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..503
FT /note="Probable folate-biopterin transporter 6"
FT /id="PRO_0000420118"
FT TRANSMEM 56..76
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 153..173
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 221..241
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 344..364
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 404..424
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 450..470
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 503 AA; 55814 MW; F3FDE141F90E872C CRC64;
METLETEKFF SDDKPLLKPI SDHSEIKTKA RRNAVVSVLI QPFQWLQMLS SRLNLSFVLG
VVLVYGVNQG FSGSIFKVVT DYYWKDVQQV QPSVVQLYMG LYYIPWVMRP IWGLFTDVFP
IKGYKRKPYF VVSGVLGLVS AIAIVVLGKL PAALALSCLL GVSAAMAIAD VVIDACIATN
SINIRSLAPD IQSLCMVCSS AGALVGYATS GVFVHQLGPQ GALGVLAFSP ATIVILGFFI
YEKRSSTVPT QKTKKDTDGL GVAVKGMCKT VKYPEVWKPS LYMFISLALN ISTHEGHFYW
YTDPTAGPAF SQEFVGIIYA VGALASMFGV LIYHKKLKGY SFRNILFFAQ LLYVFSGMLD
LVFIKRWNLT LGIPDSLFVI TEESFTKMIS KIRWIPMVVL STRLCPLGIE GTFFAFLMCI
DSFGQLASKW GGGFVLHAFG VTRHDFGNLW LVILIRNILR LVTVCFVFLV PDSDHLDDLV
PSDVLPKKQS EDDDDDDIKL LLL
