FBT7_ARATH
ID FBT7_ARATH Reviewed; 442 AA.
AC Q9XIQ7; Q8GZ34; Q94AI3;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable folate-biopterin transporter 7;
GN OrderedLocusNames=At1g64890; ORFNames=F13O11.19;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=16162503; DOI=10.1074/jbc.m507432200;
RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
RT "Higher plant plastids and cyanobacteria have folate carriers related to
RT those of trypanosomatids.";
RL J. Biol. Chem. 280:38457-38463(2005).
CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
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DR EMBL; AC006193; AAD38263.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE34302.1; -; Genomic_DNA.
DR EMBL; AK117235; BAC41911.1; -; mRNA.
DR EMBL; AY046018; AAK76692.1; -; mRNA.
DR EMBL; BT002319; AAN86152.1; -; mRNA.
DR PIR; C96672; C96672.
DR RefSeq; NP_564843.1; NM_105163.4.
DR AlphaFoldDB; Q9XIQ7; -.
DR SMR; Q9XIQ7; -.
DR STRING; 3702.AT1G64890.1; -.
DR TCDB; 2.A.71.2.6; the folate-biopterin transporter (fbt) family.
DR PaxDb; Q9XIQ7; -.
DR PRIDE; Q9XIQ7; -.
DR ProteomicsDB; 222437; -.
DR EnsemblPlants; AT1G64890.1; AT1G64890.1; AT1G64890.
DR GeneID; 842797; -.
DR Gramene; AT1G64890.1; AT1G64890.1; AT1G64890.
DR KEGG; ath:AT1G64890; -.
DR Araport; AT1G64890; -.
DR TAIR; locus:2010911; AT1G64890.
DR eggNOG; ENOG502QSTI; Eukaryota.
DR HOGENOM; CLU_018563_0_0_1; -.
DR InParanoid; Q9XIQ7; -.
DR OMA; SMYTIVF; -.
DR OrthoDB; 709372at2759; -.
DR PhylomeDB; Q9XIQ7; -.
DR PRO; PR:Q9XIQ7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9XIQ7; baseline and differential.
DR Genevisible; Q9XIQ7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; PTHR31585; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..442
FT /note="Probable folate-biopterin transporter 7"
FT /id="PRO_0000420119"
FT TRANSMEM 23..43
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 158..178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 379..399
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 24
FT /note="G -> D (in Ref. 3; BAC41911)"
FT /evidence="ECO:0000305"
FT CONFLICT 268
FT /note="I -> V (in Ref. 3; BAC41911)"
FT /evidence="ECO:0000305"
FT CONFLICT 309
FT /note="V -> L (in Ref. 4; AAK76692)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 442 AA; 48486 MW; AC1C1D94A54BF8EB CRC64;
MSSSSDTHAG ESRHRRNPIR WLLGFGFFVQ GFRGFPWLGA NFFLTEQLRV NPSVLQLLQN
SANLPMVAKP IYGVVSDSVY FFGQHRIPYI AVGALLQAIS WLAIAFLSRS NVSILALSIY
LLLSNLGASL VEVANDAIVA ESGKQKTSET QSGELPSFVW MVSSLGGILG NLLGGIAIKT
FSAQSTFLVF GILALLQFLV TINIREKSLN LPENPSPAGG IRKHLSDLSH VLRKPEISYS
IAWIAVSTAV VPVLTGTMFF YQTKFLKIDA SLLGISKVFG QIAMLLWGFA YNRWLKAMRP
RKLLTAIQVT IAFFVISDLL FVKGVYRDLG VSDSVYVLFF SGFLETLFYF KILPFTVLMA
RLCPPGCEGS LMAFVMSAIA LAFIVSGYLG IVLASFVGVT EDDFSGFTRG LAIEACCVGI
PLILTSWIYD EAETKEKSKK IE
