FBT9_ARATH
ID FBT9_ARATH Reviewed; 538 AA.
AC O22780;
DT 31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT 31-OCT-2012, sequence version 2.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Probable folate-biopterin transporter 9, chloroplastic;
DE Flags: Precursor;
GN OrderedLocusNames=At2g33280; ORFNames=F4P9.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=16162503; DOI=10.1074/jbc.m507432200;
RA Klaus S.M., Kunji E.R., Bozzo G.G., Noiriel A., de la Garza R.D.,
RA Basset G.J., Ravanel S., Rebeille F., Gregory J.F. III, Hanson A.D.;
RT "Higher plant plastids and cyanobacteria have folate carriers related to
RT those of trypanosomatids.";
RL J. Biol. Chem. 280:38457-38463(2005).
CC -!- FUNCTION: Could mediate folate transport. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Plastid, chloroplast membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Folate-
CC biopterin transporter (TC 2.A.71) family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB80646.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC002332; AAB80646.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002685; AEC08809.2; -; Genomic_DNA.
DR PIR; E84743; E84743.
DR RefSeq; NP_001318340.1; NM_001336442.1.
DR AlphaFoldDB; O22780; -.
DR SMR; O22780; -.
DR PaxDb; O22780; -.
DR PRIDE; O22780; -.
DR EnsemblPlants; AT2G33280.1; AT2G33280.1; AT2G33280.
DR GeneID; 817891; -.
DR Gramene; AT2G33280.1; AT2G33280.1; AT2G33280.
DR KEGG; ath:AT2G33280; -.
DR Araport; AT2G33280; -.
DR TAIR; locus:2051078; AT2G33280.
DR eggNOG; ENOG502QSTI; Eukaryota.
DR HOGENOM; CLU_018563_0_0_1; -.
DR InParanoid; O22780; -.
DR OrthoDB; 709372at2759; -.
DR PRO; PR:O22780; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O22780; baseline and differential.
DR GO; GO:0031969; C:chloroplast membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR039309; BT1.
DR InterPro; IPR004324; FBT.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR31585; PTHR31585; 1.
DR Pfam; PF03092; BT1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR TIGRFAMs; TIGR00788; fbt; 1.
PE 3: Inferred from homology;
KW Chloroplast; Membrane; Plastid; Reference proteome; Transit peptide;
KW Transmembrane; Transmembrane helix; Transport.
FT TRANSIT 1..57
FT /note="Chloroplast"
FT /evidence="ECO:0000255"
FT CHAIN 58..538
FT /note="Probable folate-biopterin transporter 9,
FT chloroplastic"
FT /id="PRO_0000420121"
FT TRANSMEM 85..105
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 220..240
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 447..467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 538 AA; 59023 MW; 87BC642A4F3EB7E8 CRC64;
MNNPLLSISN PVKFFKPPIP YRISLNTTIN KKQKHQSKTL VVKSNKRSTT SLTSSVSLVR
RRNNNGDGET TLVKKVGRDE KGQTVLLCAL GYWVQGLRCF SWLALNFHMA HCLNLKPSTL
QLVQYTASLP MVAKPLYGVL SDVLYIGGAR RVPYISVGVL LQGLAWGSLA IFPGAREVLP
SLMAFILLSN LGASITEVSQ DALVAEYGLR YQINGLQSYA LMASAVGGIL GNLLGGYCLL
KTPPRILFLA FTALLSLQLI VSLSSKEESV NLPRIGEVTP EISSVLGIVK KQFLDLKGIV
QVDEISQPLI WIVSSIALVP LLSGSVFCYQ TQVLNLDPSV IGMSKVIGQL MLLCLTVVYD
RYWKKLPMRA LIHIVQLLYA FSLLFDYILV KQINLAFGIS NTAFVLCFSS VAEILAQFKI
LPFSVLLANM CPGGCEGSIT SFLASTLCLS SVVSGFTGVG MANMIGITSK NYSNLPAGIL
IQSLAALVPL WFIHYVPMLE PGFEREGKRA MSKKSRRNRR VGRVIGQESF AYRRERET
