FBW10_HUMAN
ID FBW10_HUMAN Reviewed; 1052 AA.
AC Q5XX13; C9JRY8; C9JZD7; Q8TC00; Q9H0F0;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=F-box/WD repeat-containing protein 10;
DE AltName: Full=F-box and WD-40 domain-containing protein 10;
DE AltName: Full=Ubiquitin ligase-specificity factor;
GN Name=FBXW10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15520277; DOI=10.1101/gad.1255304;
RA Jin J., Cardozo T., Lovering R.C., Elledge S.J., Pagano M., Harper J.W.;
RT "Systematic analysis and nomenclature of mammalian F-box proteins.";
RL Genes Dev. 18:2573-2580(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANTS ASN-23 AND
RP THR-821.
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 630-837 (ISOFORM 4).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP FUNCTION, AND INDUCTION.
RX PubMed=20498703; DOI=10.1371/journal.pone.0010620;
RA Chaturvedi P., Parnaik V.K.;
RT "Lamin A rod domain mutants target heterochromatin protein 1alpha and beta
RT for proteasomal degradation by activation of F-box protein, FBXW10.";
RL PLoS ONE 5:E10620-E10620(2010).
CC -!- FUNCTION: Probable substrate-recognition component of a SCF (SKP1-CUL1-
CC F-box protein)-type E3 ubiquitin ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. Overexpression is leading to degradation of CBX5 and CBX1.
CC {ECO:0000269|PubMed:20498703}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q5XX13-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5XX13-2; Sequence=VSP_030727, VSP_030729;
CC Name=3;
CC IsoId=Q5XX13-3; Sequence=VSP_030728;
CC Name=4;
CC IsoId=Q5XX13-4; Sequence=VSP_039178;
CC -!- INDUCTION: By disease-causing laminin A mutants also inducing CBX5 and
CC CBX1 proteasomal degradation. {ECO:0000269|PubMed:20498703}.
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DR EMBL; AY729024; AAU43731.1; -; mRNA.
DR EMBL; AL136822; CAB66756.1; -; mRNA.
DR EMBL; AC107982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC028364; AAH28364.1; -; mRNA.
DR EMBL; BI828401; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS11199.3; -. [Q5XX13-1]
DR CCDS; CCDS58524.1; -. [Q5XX13-3]
DR RefSeq; NP_001254514.1; NM_001267585.1. [Q5XX13-1]
DR RefSeq; NP_001254515.1; NM_001267586.1. [Q5XX13-3]
DR AlphaFoldDB; Q5XX13; -.
DR SMR; Q5XX13; -.
DR BioGRID; 115772; 2.
DR IntAct; Q5XX13; 2.
DR STRING; 9606.ENSP00000379025; -.
DR GlyGen; Q5XX13; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5XX13; -.
DR PhosphoSitePlus; Q5XX13; -.
DR BioMuta; FBXW10; -.
DR DMDM; 296434504; -.
DR EPD; Q5XX13; -.
DR MassIVE; Q5XX13; -.
DR PaxDb; Q5XX13; -.
DR PeptideAtlas; Q5XX13; -.
DR PRIDE; Q5XX13; -.
DR Antibodypedia; 13562; 77 antibodies from 13 providers.
DR DNASU; 10517; -.
DR Ensembl; ENST00000301938.4; ENSP00000306937.4; ENSG00000171931.13. [Q5XX13-3]
DR Ensembl; ENST00000308799.8; ENSP00000310382.4; ENSG00000171931.13. [Q5XX13-2]
DR Ensembl; ENST00000395665.9; ENSP00000379025.4; ENSG00000171931.13. [Q5XX13-1]
DR GeneID; 10517; -.
DR KEGG; hsa:10517; -.
DR MANE-Select; ENST00000395665.9; ENSP00000379025.4; NM_001267585.2; NP_001254514.1.
DR UCSC; uc002guk.4; human. [Q5XX13-1]
DR CTD; 10517; -.
DR DisGeNET; 10517; -.
DR GeneCards; FBXW10; -.
DR HGNC; HGNC:1211; FBXW10.
DR HPA; ENSG00000171931; Tissue enriched (testis).
DR MIM; 611679; gene.
DR neXtProt; NX_Q5XX13; -.
DR OpenTargets; ENSG00000171931; -.
DR PharmGKB; PA25575; -.
DR VEuPathDB; HostDB:ENSG00000171931; -.
DR eggNOG; KOG0274; Eukaryota.
DR GeneTree; ENSGT00940000158003; -.
DR HOGENOM; CLU_011071_0_0_1; -.
DR InParanoid; Q5XX13; -.
DR OMA; SGACMKI; -.
DR OrthoDB; 133791at2759; -.
DR PhylomeDB; Q5XX13; -.
DR TreeFam; TF329175; -.
DR PathwayCommons; Q5XX13; -.
DR Reactome; R-HSA-390471; Association of TriC/CCT with target proteins during biosynthesis.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q5XX13; -.
DR BioGRID-ORCS; 10517; 11 hits in 1106 CRISPR screens.
DR ChiTaRS; FBXW10; human.
DR GeneWiki; FBXW10; -.
DR GenomeRNAi; 10517; -.
DR Pharos; Q5XX13; Tbio.
DR PRO; PR:Q5XX13; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q5XX13; protein.
DR Bgee; ENSG00000171931; Expressed in testis and 82 other tissues.
DR ExpressionAtlas; Q5XX13; baseline and differential.
DR Genevisible; Q5XX13; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..1052
FT /note="F-box/WD repeat-containing protein 10"
FT /id="PRO_0000315834"
FT REPEAT 169..206
FT /note="WD 1"
FT DOMAIN 276..323
FT /note="F-box"
FT REPEAT 409..447
FT /note="WD 2"
FT REPEAT 451..490
FT /note="WD 3"
FT REPEAT 493..532
FT /note="WD 4"
FT REPEAT 534..569
FT /note="WD 5"
FT REPEAT 572..609
FT /note="WD 6"
FT REPEAT 611..652
FT /note="WD 7"
FT REGION 766..805
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 690..719
FT /evidence="ECO:0000255"
FT COILED 986..1010
FT /evidence="ECO:0000255"
FT COMPBIAS 770..787
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 291
FT /note="R -> SMLGCMRGFPRHLPSWPSSGVSGSIFFFPG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030727"
FT VAR_SEQ 617..669
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:11230166"
FT /id="VSP_030728"
FT VAR_SEQ 760..779
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030729"
FT VAR_SEQ 779
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039178"
FT VARIANT 23
FT /note="I -> N (in dbSNP:rs11544711)"
FT /evidence="ECO:0000269|PubMed:11230166"
FT /id="VAR_038341"
FT VARIANT 372
FT /note="R -> G (in dbSNP:rs7209610)"
FT /id="VAR_057600"
FT VARIANT 821
FT /note="A -> T (in dbSNP:rs1026259)"
FT /evidence="ECO:0000269|PubMed:11230166"
FT /id="VAR_038342"
FT CONFLICT 236
FT /note="E -> K (in Ref. 2; CAB66756)"
FT /evidence="ECO:0000305"
FT CONFLICT 275
FT /note="R -> L (in Ref. 1; AAU43731 and 4; AAH28364)"
FT /evidence="ECO:0000305"
FT CONFLICT 413
FT /note="D -> V (in Ref. 2; CAB66756)"
FT /evidence="ECO:0000305"
FT CONFLICT 638
FT /note="R -> L (in Ref. 1; AAU43731)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1052 AA; 119846 MW; C5FDFC2824E918F4 CRC64;
MENLESRLKN APYFRCEKGT DSIPLCRKCE TCVLAWKIFS TKEWFCRIND ISQRRFLVGI
LKQLNSLYLL HYFQNILQTT QGKDFIYNRS RINLSKKEGK VVKSSLNQML DKTVEQKMKE
ILYWFANSTQ WTKANYTLLL LQMCNPKLLL TAANVIRVLF LREENNISGL NQDITDVCFS
PEKDHSSKSA TSQVYWTAKT QHTSLPLSKA PENEHLLGAA SNPEEPWRNS LRCISEMNRL
FSGKGDITKP GYDPCNLLVD LDDIRDLSSG FSKYRDFIRY LPIHLSKYIL RMLDRHTLNK
CASVSQHWAA MAQQVKMDLS AHGFIQNQIT FLQGSYTRGI DPNYANKVSI PVPKMVDDGK
SMRVKHPKWK LRTKNEYNLW TAYQNEETQQ VLIEERNVFC GTYNVRILSD TWDQNRVIHY
SGGDLIAVSS NRKIHLLDII QVKAIPVEFR GHAGSVRALF LCEEENFLLS GSYDLSIRYW
DLKSGVCTRI FGGHQGTITC MDLCKNRLVS GGRDCQVKVW DVDTGKCLKT FRHKDPILAT
RINDTYIVSS CERGLVKVWH IAMAQLVKTL SGHEGAVKCL FFDQWHLLSG STDGLVMAWS
MVGKYERCLM AFKHPKEVLD VSLLFLRVIS ACADGKIRIY NFLNGNCMKV LKANGRGDPV
LSFFIQGNRM VVNTESNVLM FQFEHIKWQY AVEKTKQKKN KEKEEEKEEN SLMEILSKCN
IQVHSPRESV SSKQTVIQEL LPGKPPKSRV LLKPAKFSSA VLIEELQSQG KSKSPRRDAD
DVEKAQKQGQ LETPGKLPSH PKKKSWKIPM SPDQFLLTVS ALQHAHNSGE FAYPCRPQTE
ITDVWGPSIS YPRKVLNFKG KSIQRAVDRL RLSNPPIDVK RTSIPLEIQK LQPNLKISLH
SPRVQSTIPQ PMIIRSRFSG SLKGGDQVTS SIERAVCSTG PLTSMQVIKP NRMLAPQVGT
ATLSLKKERP RIYTALDPFR VNTEFVLLTV KEEKEHQEAK MKEYQAREST GVVDPGKVSK
AAWIRKIKGL PIDNFTKQGK TAAPELGQNV FI
