FBW10_MOUSE
ID FBW10_MOUSE Reviewed; 1030 AA.
AC Q5SUS0; Q5U4G1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=F-box/WD repeat-containing protein 10;
DE AltName: Full=F-box and WD-40 domain-containing protein 10;
GN Name=Fbxw10;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6NCr; TISSUE=Hematopoietic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probable substrate-recognition component of a SCF (SKP1-CUL1-
CC F-box protein)-type E3 ubiquitin ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By
CC similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5SUS0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SUS0-2; Sequence=VSP_030730, VSP_030731;
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DR EMBL; AL645847; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC085108; AAH85108.1; -; mRNA.
DR AlphaFoldDB; Q5SUS0; -.
DR SMR; Q5SUS0; -.
DR IntAct; Q5SUS0; 1.
DR STRING; 10090.ENSMUSP00000046156; -.
DR iPTMnet; Q5SUS0; -.
DR PhosphoSitePlus; Q5SUS0; -.
DR EPD; Q5SUS0; -.
DR PaxDb; Q5SUS0; -.
DR PRIDE; Q5SUS0; -.
DR ProteomicsDB; 267345; -. [Q5SUS0-1]
DR ProteomicsDB; 267346; -. [Q5SUS0-2]
DR Ensembl; ENSMUST00000036085; ENSMUSP00000046156; ENSMUSG00000090173. [Q5SUS0-1]
DR UCSC; uc007jke.3; mouse. [Q5SUS0-2]
DR UCSC; uc007jkf.2; mouse. [Q5SUS0-1]
DR MGI; MGI:3052463; Fbxw10.
DR VEuPathDB; HostDB:ENSMUSG00000090173; -.
DR eggNOG; KOG0274; Eukaryota.
DR GeneTree; ENSGT00940000158003; -.
DR InParanoid; Q5SUS0; -.
DR OMA; SGACMKI; -.
DR PhylomeDB; Q5SUS0; -.
DR TreeFam; TF329175; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR PRO; PR:Q5SUS0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5SUS0; protein.
DR Bgee; ENSMUSG00000090173; Expressed in seminiferous tubule of testis and 49 other tissues.
DR ExpressionAtlas; Q5SUS0; baseline and differential.
DR Genevisible; Q5SUS0; MM.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome; Repeat;
KW Ubl conjugation pathway; WD repeat.
FT CHAIN 1..1030
FT /note="F-box/WD repeat-containing protein 10"
FT /id="PRO_0000315835"
FT DOMAIN 280..329
FT /note="F-box"
FT REPEAT 466..505
FT /note="WD 1"
FT REPEAT 508..547
FT /note="WD 2"
FT REPEAT 549..584
FT /note="WD 3"
FT REPEAT 587..624
FT /note="WD 4"
FT REPEAT 626..667
FT /note="WD 5"
FT REGION 709..773
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 963..992
FT /evidence="ECO:0000255"
FT COMPBIAS 709..730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 746..764
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 229..274
FT /note="EGKGESSLQCIHEMNRQIFGKGGMSRLGDDPCNLLLSLDHVQLLSS -> GK
FT SGSMKTSDIALGELGGSPYSLKKKKKSFCWVFCDLMASYINSLT (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030730"
FT VAR_SEQ 275..1030
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030731"
FT CONFLICT 155
FT /note="A -> T (in Ref. 2; AAH85108)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1030 AA; 117691 MW; FBC0609F832D0D40 CRC64;
MENREPKLKQ APYFRCEKGP NWVPVCQKCE ACVLAWKIFA TKEWFRRVND ISQRRFLVSI
LGQLNSLYLL QYFQNILETT QGKDFIYNRS RIKLSRKGGK EEEVVKSSLN QMLDKTVERK
MKEILYWFGN STHRTKANYT LLLLQMCDSN LLLTAANVIR VLFMKEWNSI SGLHDDTPDV
MFFPEKKYSG TQDTSYVSWA ARPKPVSFPM SKHLGNKLGT ENVDRETTEG KGESSLQCIH
EMNRQIFGKG GMSRLGDDPC NLLLSLDHVQ LLSSGYSKYR DFIRDLPLHL SKYILRMLDK
HSLNRCIFVS QHWATLAQQV KVDQSMHSFI QNQISLLQVT KEEKQAYTGS YTRGIDPNYA
NKVSIPVPKI VDDGKRSRSK NQKWKLRTKT DYNLWNAYQN QETQLVQMEE RNVFCGTYNI
RVLSDTFDQN RIIHYNGGDL MAISSNRKIH LLDIMQTKEL PIEFRGHAGS VRALFLSEED
NILLSGSYDL SIRYWDVKTG ACVRIFYGHQ GTITCLDVYK NRLVSGAKDG QVKEWDIETG
KCLKTFKHKD PILAAKISET YIVSSCERGI VKVWHVVTAQ LQKTLTGHEG AVKCLFFNEW
HLVSGGADGL VMAWSMVGKY ERCLMAFKHP KEVLQVSLLY LRVISACGDG KIRIYNFLNG
NCLKVIKVDA RGDPVLSFFY QGNRMVAHTD SNILVFQFEN VKWQYSSDKN KVKKSKDKEE
EREETSLGDE HSRSTIQGHS LKDSVSSKQE FSKSRVHLKQ TKNLSSDDME TPVGEVSHPL
QKLWKVPMTP DRFLLTISAL QQAHNSEEFA YPHRPRPQVI DAWGPSIPYP RKVLSLKGKS
VQHAVDQLRS SNLPTGVRQT NIPLEIQKLQ PNLKKSLHSP RVQATVPQPS LIRPKVSDSL
RGDEHLTSSI DGTMRRAGPL TSMQVIKPNR MLAPRGGTAT LSPKKERPRF YTTLDPLRMN
TGFMLMTVKE EKEFAEAKMK EYEASVSTKE VDPGKASKAA WIRKIKGLPI DNFMKEGKTA
APELGQNVFI
