FBW2_ARATH
ID FBW2_ARATH Reviewed; 317 AA.
AC Q9ZPE4; B9DGN7;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=F-box protein FBW2;
DE AltName: Full=SKP1-interacting partner 18;
GN Name=FBW2; Synonyms=SKIP18; OrderedLocusNames=At4g08980; ORFNames=T3H13.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=19423640; DOI=10.1093/dnares/dsp009;
RA Iida K., Fukami-Kobayashi K., Toyoda A., Sakaki Y., Kobayashi M., Seki M.,
RA Shinozaki K.;
RT "Analysis of multiple occurrences of alternative splicing events in
RT Arabidopsis thaliana using novel sequenced full-length cDNAs.";
RL DNA Res. 16:155-164(2009).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11077244; DOI=10.1016/s1360-1385(00)01769-6;
RA Xiao W., Jang J.-C.;
RT "F-box proteins in Arabidopsis.";
RL Trends Plant Sci. 5:454-457(2000).
RN [7]
RP INTERACTION WITH CUL1; CUL2 AND SPK1B/ASK2.
RX PubMed=12795696; DOI=10.1046/j.1365-313x.2003.01768.x;
RA Risseeuw E.P., Daskalchuk T.E., Banks T.W., Liu E., Cotelesage J.,
RA Hellmann H., Estelle M., Somers D.E., Crosby W.L.;
RT "Protein interaction analysis of SCF ubiquitin E3 ligase subunits from
RT Arabidopsis.";
RL Plant J. 34:753-767(2003).
CC -!- FUNCTION: Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase
CC complexes, which may mediate the ubiquitination and subsequent
CC proteasomal degradation of target proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By
CC similarity). Interacts with CUL1, CUL2 and SPK1B/ASK2. {ECO:0000250,
CC ECO:0000269|PubMed:12795696}.
CC -!- INTERACTION:
CC Q9ZPE4; Q9FHW7: SKP1B; NbExp=3; IntAct=EBI-604740, EBI-604076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- DOMAIN: The F-box is necessary for the interaction with ASK proteins.
CC {ECO:0000250}.
CC -!- CAUTION: Despite the nomenclature given by PubMed:11077244, FBW2 does
CC not contain any WD-40 repeat. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF128396; AAD17367.1; -; Genomic_DNA.
DR EMBL; AL161513; CAB78022.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82703.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82704.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82705.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82706.1; -; Genomic_DNA.
DR EMBL; CP002687; AEE82707.1; -; Genomic_DNA.
DR EMBL; BT002431; AAO00791.1; -; mRNA.
DR EMBL; BT008715; AAP42728.1; -; mRNA.
DR EMBL; AK317222; BAH19904.1; -; mRNA.
DR EMBL; AY084585; AAM61150.1; -; mRNA.
DR PIR; F85090; F85090.
DR RefSeq; NP_001078359.1; NM_001084890.3.
DR RefSeq; NP_001154215.1; NM_001160743.1.
DR RefSeq; NP_567343.1; NM_116967.3.
DR RefSeq; NP_849346.1; NM_179015.3.
DR RefSeq; NP_974523.1; NM_202794.1.
DR AlphaFoldDB; Q9ZPE4; -.
DR SMR; Q9ZPE4; -.
DR BioGRID; 11775; 27.
DR IntAct; Q9ZPE4; 14.
DR STRING; 3702.AT4G08980.2; -.
DR PaxDb; Q9ZPE4; -.
DR PRIDE; Q9ZPE4; -.
DR EnsemblPlants; AT4G08980.1; AT4G08980.1; AT4G08980.
DR EnsemblPlants; AT4G08980.2; AT4G08980.2; AT4G08980.
DR EnsemblPlants; AT4G08980.3; AT4G08980.3; AT4G08980.
DR EnsemblPlants; AT4G08980.4; AT4G08980.4; AT4G08980.
DR EnsemblPlants; AT4G08980.5; AT4G08980.5; AT4G08980.
DR GeneID; 826476; -.
DR Gramene; AT4G08980.1; AT4G08980.1; AT4G08980.
DR Gramene; AT4G08980.2; AT4G08980.2; AT4G08980.
DR Gramene; AT4G08980.3; AT4G08980.3; AT4G08980.
DR Gramene; AT4G08980.4; AT4G08980.4; AT4G08980.
DR Gramene; AT4G08980.5; AT4G08980.5; AT4G08980.
DR KEGG; ath:AT4G08980; -.
DR Araport; AT4G08980; -.
DR TAIR; locus:2122308; AT4G08980.
DR eggNOG; KOG1947; Eukaryota.
DR HOGENOM; CLU_044915_2_0_1; -.
DR InParanoid; Q9ZPE4; -.
DR OMA; PFVLDTY; -.
DR OrthoDB; 862639at2759; -.
DR PhylomeDB; Q9ZPE4; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9ZPE4; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9ZPE4; baseline and differential.
DR Genevisible; Q9ZPE4; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:TAIR.
DR GO; GO:0010608; P:post-transcriptional regulation of gene expression; IMP:TAIR.
DR GO; GO:0016567; P:protein ubiquitination; IDA:TAIR.
DR GO; GO:0009737; P:response to abscisic acid; IMP:TAIR.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:TAIR.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF13516; LRR_6; 2.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..317
FT /note="F-box protein FBW2"
FT /id="PRO_0000272241"
FT DOMAIN 7..54
FT /note="F-box"
SQ SEQUENCE 317 AA; 36483 MW; FB409A1EA4DAB4F2 CRC64;
MEEDCEFRHW DELIPDALGL IFSHLPLQEV LTVVPRVCKA WNRAVTGPYC WQEIDIELWS
NRFHQSDHLD RMLEMLIPRS AGSLRKLSVT GLRNDSIFSF IAQHAGSLKT LKVPRSGLTN
SGVVNVAEKL SSLTFLDLSY CCKIGPEAIQ AIGKHCKSLR EFCRNMHPLD VASVVSHDDE
AYAIANTMPK LKRLEIAYHR VSTEGVLKIL SCCVFLEFLE LRGCWDVQLD NKFFKEKFPD
MKVLGPRVIG FYDMINDWED CCSDYFSDGS DYLAWEFFED GVMGEFYEDE FEHGWDDNFY
AENAVLDMEP HIWPPSP
