FBX10_MOUSE
ID FBX10_MOUSE Reviewed; 950 AA.
AC Q7TQF2; A2ANI6; Q6AXG0; Q7TQM0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=F-box only protein 10;
GN Name=Fbxo10; Synonyms=Gm634;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 829-835, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-321 AND SER-326, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex
CC mediates ubiquitination and degradation of BCL2, an antiapoptotic
CC protein, thereby playing a role in apoptosis by controlling the
CC stability of BCL2. {ECO:0000250|UniProtKB:Q9UK96}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Component of the SCF(FBXO10) complex consisting of CUL1, SKP1
CC and FBXO10. Interacts with BCL2. Interacts with PRDM1.
CC {ECO:0000250|UniProtKB:Q9UK96}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UK96}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH54731.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL824706; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC052485; AAH52485.1; -; mRNA.
DR EMBL; BC054731; AAH54731.1; ALT_INIT; mRNA.
DR EMBL; BC079571; AAH79571.1; -; mRNA.
DR CCDS; CCDS51171.1; -.
DR RefSeq; NP_001019313.1; NM_001024142.1.
DR AlphaFoldDB; Q7TQF2; -.
DR SMR; Q7TQF2; -.
DR STRING; 10090.ENSMUSP00000058233; -.
DR iPTMnet; Q7TQF2; -.
DR PhosphoSitePlus; Q7TQF2; -.
DR MaxQB; Q7TQF2; -.
DR PaxDb; Q7TQF2; -.
DR PeptideAtlas; Q7TQF2; -.
DR PRIDE; Q7TQF2; -.
DR ProteomicsDB; 272959; -.
DR Antibodypedia; 26292; 66 antibodies from 17 providers.
DR Ensembl; ENSMUST00000052236; ENSMUSP00000058233; ENSMUSG00000048232.
DR GeneID; 269529; -.
DR KEGG; mmu:269529; -.
DR UCSC; uc008ssf.2; mouse.
DR CTD; 26267; -.
DR MGI; MGI:2686937; Fbxo10.
DR VEuPathDB; HostDB:ENSMUSG00000048232; -.
DR eggNOG; KOG1777; Eukaryota.
DR GeneTree; ENSGT00530000063425; -.
DR HOGENOM; CLU_013632_0_0_1; -.
DR InParanoid; Q7TQF2; -.
DR OMA; IFMPAWF; -.
DR OrthoDB; 281542at2759; -.
DR PhylomeDB; Q7TQF2; -.
DR TreeFam; TF313602; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 269529; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fbxo10; mouse.
DR PRO; PR:Q7TQF2; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q7TQF2; protein.
DR Bgee; ENSMUSG00000048232; Expressed in ventromedial nucleus of hypothalamus and 185 other tissues.
DR ExpressionAtlas; Q7TQF2; baseline and differential.
DR Genevisible; Q7TQF2; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; ISO:MGI.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; ISO:MGI.
DR Gene3D; 2.160.20.10; -; 3.
DR InterPro; IPR039448; Beta_helix.
DR InterPro; IPR006633; Carb-bd_sugar_hydrolysis-dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR007742; NosD_dom.
DR InterPro; IPR022441; Para_beta_helix_rpt-2.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR Pfam; PF13229; Beta_helix; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF05048; NosD; 1.
DR SMART; SM00722; CASH; 3.
DR SMART; SM00256; FBOX; 1.
DR SMART; SM00710; PbH1; 17.
DR SUPFAM; SSF51126; SSF51126; 4.
DR SUPFAM; SSF81383; SSF81383; 1.
DR TIGRFAMs; TIGR03804; para_beta_helix; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Apoptosis; Cytoplasm; Direct protein sequencing; Phosphoprotein;
KW Reference proteome; Repeat; Ubl conjugation pathway.
FT CHAIN 1..950
FT /note="F-box only protein 10"
FT /id="PRO_0000307718"
FT DOMAIN 1..48
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 198..217
FT /note="PbH1 1"
FT REPEAT 238..260
FT /note="PbH1 2"
FT REPEAT 423..444
FT /note="PbH1 3"
FT REPEAT 467..489
FT /note="PbH1 4"
FT REPEAT 490..512
FT /note="PbH1 5"
FT REPEAT 513..535
FT /note="PbH1 6"
FT REPEAT 536..558
FT /note="PbH1 7"
FT REPEAT 559..581
FT /note="PbH1 8"
FT REPEAT 582..604
FT /note="PbH1 9"
FT REPEAT 605..627
FT /note="PbH1 10"
FT REPEAT 628..650
FT /note="PbH1 11"
FT REPEAT 651..673
FT /note="PbH1 12"
FT REPEAT 713..735
FT /note="PbH1 13"
FT REPEAT 736..758
FT /note="PbH1 14"
FT REPEAT 760..782
FT /note="PbH1 15"
FT REPEAT 783..805
FT /note="PbH1 16"
FT REPEAT 828..850
FT /note="PbH1 17"
FT REGION 313..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 313..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 321
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 326
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 192
FT /note="I -> T (in Ref. 2; AAH54731)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 950 AA; 104478 MW; D526F93603113458 CRC64;
METGGLPLEL WRMILAYLHL PDLGRCSLVC RAWYELILSL DSTRWRQLCL GCTECRHPNW
PNQPDVEPES WREAFKQHYL ASKTWTKNAL DLESSICFSL FRRKKERRTL SVGPGHEFDS
LGSALAMASL YDRIVLFPGV YEEQGEIILK VPVEIVGQGK LGEVALLASI DQHCSTTRVC
NLVFMPAWFS PIMYKTTSGH IQFDNCNFEN GHIQVHGPGT CQVKFCTFKN THVFLHNVPL
CMLENCEFVG SENNCVTVEG HPSADKNWAY KYLLGLIKSS PIFLPAEDHD FLMSLDLESR
DQAWSPRTCD IVIEGSQSPT SPVCSSPKPG SKEAEVGSDG ERVAQTPDSS DGGLSPSGED
EDDEQLTYRL SYQVQGPRPV LGGSFLGPPL PGASIQLPSC LVLNSLHQEL QKDKEAMALA
SSVQGCLIRK CLFRDGKGGV FVCSYGRAKM EGNVFRNLTY AVRCIHNSKI VMLRNDIYRC
RASGIFLRLE GGGLIAGNNI YHNAEAGVDI RKKSNPLILC NQIHHGLRSG IVVLGNGKGV
IRNNQIFSNK EAGIYILYHG NPIVSGNHIF KGRAAGIAVN ENGKGLITEN VIRENQWGGV
DIRRGGVPIL RSNLICFGYS DGVVVGDEGK GLIEGNTIYA NKGCGVWMMS SSLPHVTSNH
VSYNGLYGVA VFSQKDGEFP GGHGAQENFS EDGDAILWEA ELEKEDDPLR RPITVALVES
NSINHNGASG IFVQSSEALQ VVANVIHANG DRGITIVQSS QLTRVANNSI SCNRQSGVKV
EFQCKVELRG NGIYDNRGHG IITKGDGTAV VENDIIGNRG SGLQLLPRSD TKVLKNRIHS
FRAYGIAVRG RVKALVQENI IFQGKTNKTI FQQITNNREC IMQNNKFLVF KKKSDTWRLV
NPPARPHLEN SLRGSSAAHS GHKVTAMATR ITARVEGGYH SNRSIFCTIL
