FBX15_HUMAN
ID FBX15_HUMAN Reviewed; 510 AA.
AC Q8NCQ5; B3KST3;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=F-box only protein 15;
GN Name=FBXO15; Synonyms=FBX15;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cerebellum;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8NCQ5; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-6660598, EBI-1055254;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NCQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NCQ5-2; Sequence=VSP_043033;
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DR EMBL; AK094215; BAG52845.1; -; mRNA.
DR EMBL; CH471117; EAW66537.1; -; Genomic_DNA.
DR EMBL; BC029579; AAH29579.1; -; mRNA.
DR CCDS; CCDS45884.1; -. [Q8NCQ5-1]
DR RefSeq; NP_001136430.1; NM_001142958.1. [Q8NCQ5-1]
DR RefSeq; NP_689889.1; NM_152676.2. [Q8NCQ5-2]
DR RefSeq; XP_016881092.1; XM_017025603.1. [Q8NCQ5-2]
DR RefSeq; XP_016881093.1; XM_017025604.1. [Q8NCQ5-2]
DR AlphaFoldDB; Q8NCQ5; -.
DR BioGRID; 128386; 10.
DR IntAct; Q8NCQ5; 6.
DR STRING; 9606.ENSP00000393154; -.
DR iPTMnet; Q8NCQ5; -.
DR PhosphoSitePlus; Q8NCQ5; -.
DR BioMuta; FBXO15; -.
DR DMDM; 384872371; -.
DR MassIVE; Q8NCQ5; -.
DR PaxDb; Q8NCQ5; -.
DR PeptideAtlas; Q8NCQ5; -.
DR PRIDE; Q8NCQ5; -.
DR ProteomicsDB; 72921; -. [Q8NCQ5-1]
DR ProteomicsDB; 72922; -. [Q8NCQ5-2]
DR Antibodypedia; 42215; 210 antibodies from 25 providers.
DR DNASU; 201456; -.
DR Ensembl; ENST00000419743.7; ENSP00000393154.2; ENSG00000141665.13. [Q8NCQ5-1]
DR GeneID; 201456; -.
DR KEGG; hsa:201456; -.
DR MANE-Select; ENST00000419743.7; ENSP00000393154.2; NM_001142958.2; NP_001136430.1.
DR UCSC; uc002llf.3; human. [Q8NCQ5-1]
DR CTD; 201456; -.
DR DisGeNET; 201456; -.
DR GeneCards; FBXO15; -.
DR HGNC; HGNC:13617; FBXO15.
DR HPA; ENSG00000141665; Tissue enhanced (fallopian tube, testis).
DR MIM; 609093; gene.
DR neXtProt; NX_Q8NCQ5; -.
DR OpenTargets; ENSG00000141665; -.
DR PharmGKB; PA134894755; -.
DR VEuPathDB; HostDB:ENSG00000141665; -.
DR eggNOG; ENOG502QPX2; Eukaryota.
DR GeneTree; ENSGT00390000017498; -.
DR HOGENOM; CLU_047012_0_0_1; -.
DR InParanoid; Q8NCQ5; -.
DR OMA; CTGCVNR; -.
DR OrthoDB; 1232375at2759; -.
DR PhylomeDB; Q8NCQ5; -.
DR TreeFam; TF332483; -.
DR PathwayCommons; Q8NCQ5; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8NCQ5; -.
DR BioGRID-ORCS; 201456; 5 hits in 1106 CRISPR screens.
DR ChiTaRS; FBXO15; human.
DR GenomeRNAi; 201456; -.
DR Pharos; Q8NCQ5; Tbio.
DR PRO; PR:Q8NCQ5; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q8NCQ5; protein.
DR Bgee; ENSG00000141665; Expressed in bronchial epithelial cell and 142 other tissues.
DR ExpressionAtlas; Q8NCQ5; baseline and differential.
DR Genevisible; Q8NCQ5; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..510
FT /note="F-box only protein 15"
FT /id="PRO_0000119893"
FT DOMAIN 77..117
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT VAR_SEQ 1..76
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043033"
FT VARIANT 496
FT /note="Y -> H (in dbSNP:rs35815390)"
FT /id="VAR_049040"
SQ SEQUENCE 510 AA; 57258 MW; 99760CBB50B9DC8E CRC64;
MATGRGRILQ QHWLGLQTLR GPSRGGGAAR GRARAFGCRK GPGVKLSAGS AALRCHAGGG
QHWESSFSCC SGFLDGMPSE ILLKIFSYLD AVSLLCTGCV SRRFYHLAND NFIWIGIYST
AFSPARSNWK FNSVEKIAMS MSFLSVQDKE AGYWKKEYIT KQIASVKAAL ADILKPVNPY
TGLPVKTKEA LRIFGLGWAI ILKEKGGKEY IMEHVDLSIN DTSVTVIWYG KKWPCLASLS
TLDLCGMTPV FTDWYKTPTK HRLRWHSLIA KYNLSHLTIS TMIGCDRLIR IFCLHPGLLV
GVWKKEEELA FVMANLHFHH LVERSTLGSA TIPYELPPHS PFLDDSPEYG LHGYQLHVDL
HSGGVFYLCG TFRNLFTKRG NIENGHVKLI VIHLKNNREH LPLIGKVGLS WKTDIFDGCI
KSCSMMDVTL LDEHGKPFWC FSSPVCLRSP ATPSDSSSFL GQTYNVDYVD AEGRVHVELV
WIRETEEYLI VNLVLYLSIA KINHWFGTEY
