ID   FBX15_MOUSE             Reviewed;         433 AA.
AC   Q9QZN0;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=F-box only protein 15;
GN   Name=Fbxo15; Synonyms=Fbx15;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH SKP1.
RX   PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA   Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT   "A family of mammalian F-box proteins.";
RL   Curr. Biol. 9:1180-1182(1999).
RN   [2]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=12665572; DOI=10.1128/mcb.23.8.2699-2708.2003;
RA   Tokuzawa Y., Kaiho E., Maruyama M., Takahashi K., Mitsui K., Maeda M.,
RA   Niwa H., Yamanaka S.;
RT   "Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem
RT   cell self-renewal and mouse development.";
RL   Mol. Cell. Biol. 23:2699-2708(2003).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in testis. {ECO:0000269|PubMed:10531037,
CC       ECO:0000269|PubMed:12665572}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in undifferentiated embryonic stem
CC       cells, as well as early embryo from two-cell stage to blastocyst.
CC       {ECO:0000269|PubMed:12665572}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF09139.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AF176530; AAF09139.1; ALT_INIT; mRNA.
DR   CCDS; CCDS37877.2; -.
DR   AlphaFoldDB; Q9QZN0; -.
DR   CORUM; Q9QZN0; -.
DR   STRING; 10090.ENSMUSP00000045925; -.
DR   iPTMnet; Q9QZN0; -.
DR   PhosphoSitePlus; Q9QZN0; -.
DR   PaxDb; Q9QZN0; -.
DR   PRIDE; Q9QZN0; -.
DR   ProteomicsDB; 271879; -.
DR   MGI; MGI:1354755; Fbxo15.
DR   eggNOG; ENOG502QPX2; Eukaryota.
DR   InParanoid; Q9QZN0; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   ChiTaRS; Fbxo15; mouse.
DR   PRO; PR:Q9QZN0; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9QZN0; protein.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IDA:MGI.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IC:MGI.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..433
FT                   /note="F-box only protein 15"
FT                   /id="PRO_0000119895"
FT   DOMAIN          1..41
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   433 AA;  49486 MW;  0144B60F395B2694 CRC64;
     MPSEILVKIL SYLDAVTLVC IGCVSRRFYH LADDNLIWVR KYAAAFRSKR SRWKATSVEE
     TATSLSLLSV WDKEDGYWKK EYITKQISSV RAALTNSLSP VKRRTSLPSK TKESLRISGL
     GWTIILREAS GKEHIMQHSN LSVNDNSVTV FWHDKNWPHV DTLSTLDLYG ATPIFMEQYK
     GPNTSCPRWL SLIEKYDLSN LRKSAMIGCD RHVRVFCVNP GLLVGLWQEN GGLAFVMANI
     HSHGLFERSI MGSDTIPYTL PPDTTFVDNY PDSMTFYGDK GFQLHIDIHG SKTYFLCSTF
     HNLFCRRAGI NNGYVKFLMI NLKNNREHLP LVGKVGLEWR TDCLNGRIES CIVVDMTLLD
     EDKKPIWYVS SPVCLRSACL PDFPQPAYSF EYMDSVGGVC ADLGWFENTD EYFIVRLDIY
     LSVAKLQQWF GRQ