FBX16_HUMAN
ID FBX16_HUMAN Reviewed; 292 AA.
AC Q8IX29; Q3T1B2; Q3T1B3; Q3T1B4;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=F-box only protein 16;
GN Name=FBXO16; Synonyms=FBX16;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RX PubMed=12243353;
RA Cheng H., Ma Y., Ni X., Jiang M., Guo L., Jin W., Xu W., Cao G., Ji C.,
RA Yin K., Gu S., Ma Y., Xie Y., Mao Y.;
RT "cDNA cloning and expression analysis of a novel human F-box only
RT protein.";
RL Mol. Cells 14:56-59(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC and promotes their ubiquitination and degradation.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IX29; P25800: LMO1; NbExp=3; IntAct=EBI-12063229, EBI-8639312;
CC Q8IX29; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-12063229, EBI-10288852;
CC Q8IX29; Q15014: MORF4L2; NbExp=3; IntAct=EBI-12063229, EBI-399257;
CC Q8IX29; Q9UKK6: NXT1; NbExp=5; IntAct=EBI-12063229, EBI-301889;
CC Q8IX29; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-12063229, EBI-2130429;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IX29-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IX29-2; Sequence=VSP_045600;
CC -!- TISSUE SPECIFICITY: Expressed in heart, spleen and colon.
CC {ECO:0000269|PubMed:12243353}.
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DR EMBL; AF453435; AAN76812.1; -; mRNA.
DR EMBL; AC025871; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC074986; AAH74986.1; -; mRNA.
DR EMBL; BC102026; AAI02027.1; -; mRNA.
DR EMBL; BC102027; AAI02028.1; -; mRNA.
DR EMBL; BC102028; AAI02029.1; -; mRNA.
DR CCDS; CCDS59099.1; -. [Q8IX29-2]
DR CCDS; CCDS6068.1; -. [Q8IX29-1]
DR RefSeq; NP_001245140.1; NM_001258211.1. [Q8IX29-2]
DR RefSeq; NP_758954.1; NM_172366.3. [Q8IX29-1]
DR AlphaFoldDB; Q8IX29; -.
DR SMR; Q8IX29; -.
DR BioGRID; 127606; 17.
DR IntAct; Q8IX29; 6.
DR STRING; 9606.ENSP00000369604; -.
DR iPTMnet; Q8IX29; -.
DR PhosphoSitePlus; Q8IX29; -.
DR BioMuta; FBXO16; -.
DR DMDM; 30580423; -.
DR MassIVE; Q8IX29; -.
DR MaxQB; Q8IX29; -.
DR PaxDb; Q8IX29; -.
DR PeptideAtlas; Q8IX29; -.
DR PRIDE; Q8IX29; -.
DR ProteomicsDB; 61869; -.
DR ProteomicsDB; 70969; -. [Q8IX29-1]
DR Antibodypedia; 23118; 110 antibodies from 16 providers.
DR DNASU; 157574; -.
DR Ensembl; ENST00000380254.7; ENSP00000369604.2; ENSG00000214050.8. [Q8IX29-1]
DR Ensembl; ENST00000518734.5; ENSP00000429687.1; ENSG00000214050.8. [Q8IX29-2]
DR GeneID; 157574; -.
DR KEGG; hsa:157574; -.
DR MANE-Select; ENST00000380254.7; ENSP00000369604.2; NM_172366.4; NP_758954.1.
DR UCSC; uc003xgu.5; human. [Q8IX29-1]
DR CTD; 157574; -.
DR DisGeNET; 157574; -.
DR GeneCards; FBXO16; -.
DR HGNC; HGNC:13618; FBXO16.
DR HPA; ENSG00000214050; Tissue enhanced (epididymis, pituitary gland).
DR MIM; 608519; gene.
DR neXtProt; NX_Q8IX29; -.
DR OpenTargets; ENSG00000214050; -.
DR PharmGKB; PA134901223; -.
DR VEuPathDB; HostDB:ENSG00000214050; -.
DR eggNOG; KOG0274; Eukaryota.
DR GeneTree; ENSGT00940000159021; -.
DR HOGENOM; CLU_065593_0_0_1; -.
DR InParanoid; Q8IX29; -.
DR OMA; WQWKSIV; -.
DR OrthoDB; 1047475at2759; -.
DR PhylomeDB; Q8IX29; -.
DR TreeFam; TF328656; -.
DR PathwayCommons; Q8IX29; -.
DR SignaLink; Q8IX29; -.
DR BioGRID-ORCS; 157574; 6 hits in 1107 CRISPR screens.
DR ChiTaRS; FBXO16; human.
DR GenomeRNAi; 157574; -.
DR Pharos; Q8IX29; Tdark.
DR PRO; PR:Q8IX29; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q8IX29; protein.
DR Bgee; ENSG00000214050; Expressed in adenohypophysis and 117 other tissues.
DR ExpressionAtlas; Q8IX29; baseline and differential.
DR Genevisible; Q8IX29; HS.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..292
FT /note="F-box only protein 16"
FT /id="PRO_0000119896"
FT DOMAIN 86..132
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 188..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..278
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 34..45
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_045600"
FT VARIANT 75
FT /note="R -> Q (in dbSNP:rs3735726)"
FT /id="VAR_020409"
FT VARIANT 254
FT /note="M -> I (in dbSNP:rs1390963)"
FT /id="VAR_024442"
FT VARIANT 255
FT /note="T -> N (in dbSNP:rs7016831)"
FT /id="VAR_049041"
FT CONFLICT 254..255
FT /note="MT -> IN (in Ref. 3; AAI02028)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 292 AA; 34588 MW; 0A7030EFE682EDFD CRC64;
MMAFAPPKNT DGPKMQTKMS TWTPLNHQLL NDRVFEERRA LLGKWFDKWT DSQRRRILTG
LLERCSLSQQ KFCCRKLQEK IPAEALDFTT KLPRVLSLYI FSFLDPRSLC RCAQVCWHWK
NLAELDQLWM LKCLRFNWYI NFSPTPFEQG IWKKHYIQMV KELHITKPKT PPKDGFVIAD
VQLVTSNSPE EKQSPLSAFR SSSSLRKKNN SGEKALPPWR SSDKHPTDII RFNYLDNRDP
METVQQGRRK RNQMTPDFSR QSHDKKNKLQ DRTRLRKAQS MMSRRNPFPL CP
