FBX16_MOUSE
ID FBX16_MOUSE Reviewed; 334 AA.
AC Q9QZM9; Q3TP74; Q8C5V6;
DT 09-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=F-box only protein 16;
GN Name=Fbxo16; Synonyms=Fbx16;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT "A family of mammalian F-box proteins.";
RL Curr. Biol. 9:1180-1182(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC and promotes their ubiquitination and degradation.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC {ECO:0000250}.
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DR EMBL; AF176531; AAF09140.1; -; mRNA.
DR EMBL; AK077043; BAC36580.1; -; mRNA.
DR EMBL; AK164657; BAE37863.1; -; mRNA.
DR CCDS; CCDS36956.1; -.
DR RefSeq; NP_056610.1; NM_015795.1.
DR AlphaFoldDB; Q9QZM9; -.
DR SMR; Q9QZM9; -.
DR STRING; 10090.ENSMUSP00000130805; -.
DR iPTMnet; Q9QZM9; -.
DR PhosphoSitePlus; Q9QZM9; -.
DR PaxDb; Q9QZM9; -.
DR PRIDE; Q9QZM9; -.
DR ProteomicsDB; 270964; -.
DR Antibodypedia; 23118; 110 antibodies from 16 providers.
DR DNASU; 50759; -.
DR Ensembl; ENSMUST00000224629; ENSMUSP00000153015; ENSMUSG00000034532.
DR GeneID; 50759; -.
DR KEGG; mmu:50759; -.
DR UCSC; uc007ujd.1; mouse.
DR CTD; 157574; -.
DR MGI; MGI:1354706; Fbxo16.
DR VEuPathDB; HostDB:ENSMUSG00000034532; -.
DR eggNOG; KOG0274; Eukaryota.
DR GeneTree; ENSGT00940000159021; -.
DR HOGENOM; CLU_065593_0_0_1; -.
DR InParanoid; Q9QZM9; -.
DR OMA; WQWKSIV; -.
DR OrthoDB; 1047475at2759; -.
DR PhylomeDB; Q9QZM9; -.
DR TreeFam; TF328656; -.
DR BioGRID-ORCS; 50759; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Fbxo16; mouse.
DR PRO; PR:Q9QZM9; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q9QZM9; protein.
DR Bgee; ENSMUSG00000034532; Expressed in animal zygote and 109 other tissues.
DR ExpressionAtlas; Q9QZM9; baseline and differential.
DR Genevisible; Q9QZM9; MM.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..334
FT /note="F-box only protein 16"
FT /id="PRO_0000119897"
FT DOMAIN 86..132
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 168..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 314..334
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..206
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 102
FT /note="S -> F (in Ref. 2; BAC36580)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 334 AA; 38987 MW; E5826DA24FE3684B CRC64;
MMAFAPPKSI DGPKMQTKMS TWTPLNHQLL NDQVFEERRA LLGKWFDKWT DSQRRRILTG
LLERCSLSQQ KFCCRKLQEK IPAEALDFTT KLPRVLSVYI FSFLDPRSLC RCAQVSWYWK
SLAELDQLWM LKCLRFNWYI SFSPTPFEQG VWKKHYIQMV RELHVTKPKT PPKDEFTTAD
VQPIPGNSPD EKQSPSLAFR SSSSLRKKNN PGEKELPPWR SSDKHPTDII RFNYLDNCDP
ELFRLGRRKR SEVTPDFKRQ LRDKKNKLQD RARLRKAQSL ISLSSPPKVP VRLAWPLHLP
VAPSDREAAT EALLEHLQKH PGLQSPSPRL QSQS
