FBX17_MOUSE
ID FBX17_MOUSE Reviewed; 286 AA.
AC Q9QZM8;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 27-MAY-2002, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=F-box only protein 17;
DE AltName: Full=F-box only protein 26;
GN Name=Fbxo17; Synonyms=Fbx17, Fbxo26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=10531037; DOI=10.1016/s0960-9822(00)80021-4;
RA Winston J.T., Koepp D.M., Zhu C., Elledge S.J., Harper J.W.;
RT "A family of mammalian F-box proteins.";
RL Curr. Biol. 9:1180-1182(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=18203720; DOI=10.1074/jbc.m709508200;
RA Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.;
RT "Diversity in tissue expression, substrate binding, and SCF complex
RT formation for a lectin family of ubiquitin ligases.";
RL J. Biol. Chem. 283:12717-12729(2008).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. Able to recognize and bind
CC denatured glycoproteins, which are modified with complex-type
CC oligosaccharides. Also recognizes sulfated glycans. Does not bind high-
CC mannose glycoproteins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC Interacts with SKP1 and CUL1 (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9QZM8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9QZM8-2; Sequence=VSP_012981, VSP_012982;
CC -!- TISSUE SPECIFICITY: Expressed primarily in the brain.
CC {ECO:0000269|PubMed:18203720}.
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DR EMBL; AF176532; AAF09141.1; -; mRNA.
DR EMBL; BC026470; AAH26470.1; -; mRNA.
DR CCDS; CCDS39863.2; -. [Q9QZM8-1]
DR CCDS; CCDS80688.1; -. [Q9QZM8-2]
DR RefSeq; NP_001297616.1; NM_001310687.1. [Q9QZM8-2]
DR RefSeq; NP_056611.2; NM_015796.2. [Q9QZM8-1]
DR AlphaFoldDB; Q9QZM8; -.
DR SMR; Q9QZM8; -.
DR STRING; 10090.ENSMUSP00000032818; -.
DR PaxDb; Q9QZM8; -.
DR PRIDE; Q9QZM8; -.
DR Antibodypedia; 68422; 54 antibodies from 17 providers.
DR DNASU; 50760; -.
DR Ensembl; ENSMUST00000032818; ENSMUSP00000032818; ENSMUSG00000030598. [Q9QZM8-1]
DR Ensembl; ENSMUST00000108278; ENSMUSP00000103913; ENSMUSG00000030598. [Q9QZM8-1]
DR Ensembl; ENSMUST00000108279; ENSMUSP00000103914; ENSMUSG00000030598. [Q9QZM8-2]
DR Ensembl; ENSMUST00000167118; ENSMUSP00000130422; ENSMUSG00000030598. [Q9QZM8-1]
DR GeneID; 50760; -.
DR KEGG; mmu:50760; -.
DR UCSC; uc009fzl.2; mouse. [Q9QZM8-2]
DR UCSC; uc009fzn.2; mouse. [Q9QZM8-1]
DR CTD; 115290; -.
DR MGI; MGI:1354707; Fbxo17.
DR VEuPathDB; HostDB:ENSMUSG00000030598; -.
DR eggNOG; ENOG502RZA6; Eukaryota.
DR GeneTree; ENSGT00940000162455; -.
DR HOGENOM; CLU_068548_0_0_1; -.
DR InParanoid; Q9QZM8; -.
DR OMA; YAVVQRC; -.
DR PhylomeDB; Q9QZM8; -.
DR TreeFam; TF320527; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 50760; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Fbxo17; mouse.
DR PRO; PR:Q9QZM8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9QZM8; protein.
DR Bgee; ENSMUSG00000030598; Expressed in humerus cartilage element and 144 other tissues.
DR ExpressionAtlas; Q9QZM8; baseline and differential.
DR Genevisible; Q9QZM8; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:GOC.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR InterPro; IPR007397; F-box-assoc_dom.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039752; F-box_only.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12125; PTHR12125; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF04300; FBA; 1.
DR SMART; SM01198; FBA; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS51114; FBA; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..286
FT /note="F-box only protein 17"
FT /id="PRO_0000119899"
FT DOMAIN 15..62
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT DOMAIN 107..283
FT /note="FBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
FT VAR_SEQ 240..242
FT /note="VSH -> GLP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10531037"
FT /id="VSP_012981"
FT VAR_SEQ 243..286
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10531037"
FT /id="VSP_012982"
SQ SEQUENCE 286 AA; 32500 MW; F303B2414406259B CRC64;
MGARPSRRQM TEARRLALTK LPPELLVQVL SHVPPRALVT RCRPVCRAWR DLVDGPSIWL
LQLARDRSAE GRALYALAQR CPADADADAD ADGNRHDEFP FCALARFCLR APFGRNLIHN
SCGEQGFRGW EVEHGGNGWA VEKNLTLVPG APSQTCFVTS FEWCSKRQLV DLVKEGVWQE
LLDSGQIEIC IADWWGAREN CGCIYRLRVR LLDEYENEVV KFSASPNPVL QWTERSCRQV
SHVFTNFGKG IRYVSFEQYG RDTRSWVGHY GALVTHSSVR VRIRLS
