ID   FBX17_RAT               Reviewed;         250 AA.
AC   Q6AY27;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=F-box only protein 17;
GN   Name=Fbxo17;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Brown Norway; TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Able to recognize and bind
CC       denatured glycoproteins, which are modified with complex-type
CC       oligosaccharides. Also recognizes sulfated glycans. Does not bind high-
CC       mannose glycoproteins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       Interacts with SKP1 and CUL1 (By similarity). {ECO:0000250}.
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DR   EMBL; BC079218; AAH79218.1; -; mRNA.
DR   RefSeq; NP_001013082.2; NM_001013064.2.
DR   RefSeq; XP_017444395.1; XM_017588906.1.
DR   RefSeq; XP_017444396.1; XM_017588907.1.
DR   AlphaFoldDB; Q6AY27; -.
DR   SMR; Q6AY27; -.
DR   STRING; 10116.ENSRNOP00000027006; -.
DR   PaxDb; Q6AY27; -.
DR   PRIDE; Q6AY27; -.
DR   Ensembl; ENSRNOT00000027006; ENSRNOP00000027006; ENSRNOG00000019942.
DR   GeneID; 292757; -.
DR   KEGG; rno:292757; -.
DR   UCSC; RGD:1308308; rat.
DR   CTD; 115290; -.
DR   RGD; 1308308; Fbxo17.
DR   eggNOG; ENOG502RZA6; Eukaryota.
DR   GeneTree; ENSGT00940000162455; -.
DR   HOGENOM; CLU_068548_0_0_1; -.
DR   InParanoid; Q6AY27; -.
DR   OMA; YAVVQRC; -.
DR   OrthoDB; 922544at2759; -.
DR   PhylomeDB; Q6AY27; -.
DR   TreeFam; TF320527; -.
DR   Reactome; R-RNO-8951664; Neddylation.
DR   Reactome; R-RNO-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   PRO; PR:Q6AY27; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000019942; Expressed in testis and 10 other tissues.
DR   Genevisible; Q6AY27; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:GOC.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR007397; F-box-assoc_dom.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039752; F-box_only.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12125; PTHR12125; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF04300; FBA; 1.
DR   SMART; SM01198; FBA; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS51114; FBA; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..250
FT                   /note="F-box only protein 17"
FT                   /id="PRO_0000119900"
FT   DOMAIN          15..62
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          99..250
FT                   /note="FBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
SQ   SEQUENCE   250 AA;  28234 MW;  277BCB3C9DE7536B CRC64;
     MGAQPSRRRM TEAQHMALAE LPPELLLQVL SHVPPRALVT RCRPVCRAWR DLVDGPSVWL
     LQLARDRSAE GRALYALAQS CPADRNGHDD FPLCALARFC LLAPLGRNLI YNSCGEQGFR
     GWEVEHGGNG WAVEKNLTMV PGAPSQTCFV TSFEWCFKRQ LVDLVKEGVW QELLDSAQIE
     IYIADWWGAR ENCGCIYRLR VRLLDEHENE VVKFSASPNP VLQWTERSCR QVSPDCSLNP
     GLLQGLSRLH