ID   FBX21_PONAB             Reviewed;         621 AA.
AC   Q5R5S1;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=F-box only protein 21;
GN   Name=FBXO21;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; CR860785; CAH92895.1; -; mRNA.
DR   AlphaFoldDB; Q5R5S1; -.
DR   SMR; Q5R5S1; -.
DR   STRING; 9601.ENSPPYP00000005705; -.
DR   eggNOG; ENOG502QS7Z; Eukaryota.
DR   InParanoid; Q5R5S1; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   Gene3D; 2.30.30.390; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR011722; Hemimethylated_DNA-bd_dom.
DR   InterPro; IPR036623; Hemimethylated_DNA-bd_sf.
DR   InterPro; IPR032698; SirB1_N.
DR   Pfam; PF13369; Transglut_core2; 1.
DR   Pfam; PF08755; YccV-like; 1.
DR   SMART; SM00992; YccV-like; 1.
DR   SUPFAM; SSF141255; SSF141255; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   TIGRFAMs; TIGR02097; yccV; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..621
FT                   /note="F-box only protein 21"
FT                   /id="PRO_0000119905"
FT   DOMAIN          28..77
FT                   /note="F-box"
SQ   SEQUENCE   621 AA;  71447 MW;  6E3B761858BD7F87 CRC64;
     MAAAAVDSAM EVVPALAEEA APEVAGLSCL VNLPGEVLEY ILCCGSLTAA DIGRVSSTCR
     RLRELCQSSG KVWKEQFRVR WPSLMKHYSP TDYVNWLEEY KVRQKAGLEA RKIVASFSKR
     FFSEHVPCNG FSDIENLEGP EIFFEDELVC ILNMEGRKAL TWKYYAKKIL YYLRQQKILN
     NLKAFLQQPD DYESYLEGAV YIDQYCNPLS DISLKDIQAQ IDSIVELVCK TLRGINSRHP
     SLAFKAGESS MIVEIELQSQ VLDAMNYVLY DQLKFQGNRM DYYNALNLYM HQVLIRRTGI
     PISMSLLYLT IARQLGVPLE PVNFPSHFLL RWCQGAEGAT LDIFDYIYID AFGKGKQLTV
     KECEYLIGQH VTAALYGVVN VKKVLQRMVG NLLSLGKREG IDQSYQLLRD SLDLYLAMYP
     DQVQLLLLQA RLYFHLGIWP EKVLDILQHI QTLDPGQHGA VGYLVQHTLE HIERKKEEVG
     VEVKLRSDEK HRDVCYSIGL IMKHKRYGYN CVIYGWDPTC MMGHEWIRNM NVHSLPHGHH
     QPFYNVLVED GSCRYAAQEN LEYNVEPQEI SHPDVGRYFS EFTGTHYIPN AELEIRYPED
     LEFVYETVQN IYSAKKENID E