ID   FBX22_PONAB             Reviewed;         403 AA.
AC   Q5RE08;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=F-box only protein 22;
GN   Name=FBXO22;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Promotes the proteasome-
CC       dependent degradation of key sarcomeric proteins, such as alpha-actinin
CC       (ACTN2) and filamin-C (FLNC), essential for maintenance of normal
CC       contractile function (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250}.
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DR   EMBL; CR857731; CAH89999.1; -; mRNA.
DR   RefSeq; NP_001127222.1; NM_001133750.1.
DR   AlphaFoldDB; Q5RE08; -.
DR   STRING; 9601.ENSPPYP00000007567; -.
DR   GeneID; 100174277; -.
DR   KEGG; pon:100174277; -.
DR   CTD; 26263; -.
DR   eggNOG; ENOG502QSZ2; Eukaryota.
DR   InParanoid; Q5RE08; -.
DR   OrthoDB; 681238at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR019494; FIST_C.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF10442; FIST_C; 1.
DR   SMART; SM01204; FIST_C; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Phosphoprotein; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..403
FT                   /note="F-box only protein 22"
FT                   /id="PRO_0000119908"
FT   DOMAIN          19..71
FT                   /note="F-box"
FT   MOD_RES         1
FT                   /note="N-acetylmethionine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEZ5"
FT   MOD_RES         128
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEZ5"
FT   MOD_RES         194
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8NEZ5"
SQ   SEQUENCE   403 AA;  44632 MW;  D9CEF2D3BBCE2087 CRC64;
     MESVGCCGDC RGSSVDPRST FVLSNLAEVV ERVLTFLPAK ALLRVACVCR LWRECVRRVL
     RTHRSVTWIS AGLAEASHLE RHCLVRVVAE ELENVRILPH TVLYMADSET FISLEECRGH
     KRARKRTSME TALALEKLFP KQCQVLGIVT PGIVVTPMGS GSNRPQEIEI GESGFALLFP
     QIEGIKIQPF HFIKDPKNLT LERHQLTEVG LLDNPELRVV LVFGYNCCKV GASNYLQQVV
     STFSDMNIIL AGGQVDNLSS LTSEKNPLDI DASGVVGLSF SGHRIQSATV LLNEDVSDEK
     TAEAAMQRLR AANIPEQNTI GFMFACVGRG FQYYRAKGNV EADAFRKFFP SVPLFGFFGN
     GEIGCDRIVT GNFILRKCNE VKDDDLFHSY TTIMALIHLG SSK