FBX24_HUMAN
ID FBX24_HUMAN Reviewed; 580 AA.
AC O75426; A4D2D4; B4DX91; B4DY42; Q9H0G1;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 2.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=F-box only protein 24;
GN Name=FBXO24; Synonyms=FBX24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=10531035; DOI=10.1016/s0960-9822(00)80020-2;
RA Cenciarelli C., Chiaur D.S., Guardavaccaro D., Parks W., Vidal M.,
RA Pagano M.;
RT "Identification of a family of human F-box proteins.";
RL Curr. Biol. 9:1177-1179(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Gloeckner G., Rosenthal A., Scherer S., Weber J., Schattevoy R.,
RA Tsui L.-C.;
RT "Large scale analysis of two regions in human chromosome 7q22: annotation
RT of 650 kb of genomic sequence around the PCOLCE and CUTL1 loci reveals 17
RT genes.";
RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- INTERACTION:
CC O75426; P08238: HSP90AB1; NbExp=2; IntAct=EBI-6425658, EBI-352572;
CC O75426; Q8WVJ2: NUDCD2; NbExp=2; IntAct=EBI-6425658, EBI-1052153;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=O75426-1; Sequence=Displayed;
CC Name=2;
CC IsoId=O75426-2; Sequence=VSP_011351, VSP_011352, VSP_011353;
CC Name=3;
CC IsoId=O75426-3; Sequence=VSP_043459;
CC Name=4;
CC IsoId=O75426-4; Sequence=VSP_043458;
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DR EMBL; AF174604; AAF04525.1; -; mRNA.
DR EMBL; AF053356; AAC78801.1; -; Genomic_DNA.
DR EMBL; AL136811; CAB66745.1; -; mRNA.
DR EMBL; AK301864; BAG63303.1; -; mRNA.
DR EMBL; AK302252; BAG63604.1; -; mRNA.
DR EMBL; AC069281; AAP21862.1; -; Genomic_DNA.
DR EMBL; AC069281; AAP21863.1; -; Genomic_DNA.
DR EMBL; CH236956; EAL23827.1; -; Genomic_DNA.
DR EMBL; CH471091; EAW76517.1; -; Genomic_DNA.
DR EMBL; BC067293; AAH67293.1; -; mRNA.
DR CCDS; CCDS55138.1; -. [O75426-4]
DR CCDS; CCDS5698.1; -. [O75426-1]
DR CCDS; CCDS5699.2; -. [O75426-3]
DR RefSeq; NP_001156971.1; NM_001163499.1. [O75426-4]
DR RefSeq; NP_036304.2; NM_012172.4. [O75426-3]
DR RefSeq; NP_277041.1; NM_033506.2. [O75426-1]
DR AlphaFoldDB; O75426; -.
DR SMR; O75426; -.
DR BioGRID; 117647; 11.
DR IntAct; O75426; 16.
DR STRING; 9606.ENSP00000416558; -.
DR iPTMnet; O75426; -.
DR PhosphoSitePlus; O75426; -.
DR BioMuta; FBXO24; -.
DR MassIVE; O75426; -.
DR PaxDb; O75426; -.
DR PeptideAtlas; O75426; -.
DR PRIDE; O75426; -.
DR ProteomicsDB; 49996; -. [O75426-1]
DR ProteomicsDB; 49997; -. [O75426-2]
DR ProteomicsDB; 49998; -. [O75426-3]
DR ProteomicsDB; 49999; -. [O75426-4]
DR Antibodypedia; 30754; 227 antibodies from 22 providers.
DR DNASU; 26261; -.
DR Ensembl; ENST00000241071.11; ENSP00000241071.6; ENSG00000106336.13. [O75426-1]
DR Ensembl; ENST00000427939.2; ENSP00000416558.2; ENSG00000106336.13. [O75426-3]
DR Ensembl; ENST00000465843.5; ENSP00000419602.1; ENSG00000106336.13. [O75426-2]
DR Ensembl; ENST00000468962.5; ENSP00000420239.1; ENSG00000106336.13. [O75426-4]
DR GeneID; 26261; -.
DR KEGG; hsa:26261; -.
DR MANE-Select; ENST00000241071.11; ENSP00000241071.6; NM_033506.3; NP_277041.1.
DR UCSC; uc003uvl.2; human. [O75426-1]
DR CTD; 26261; -.
DR DisGeNET; 26261; -.
DR GeneCards; FBXO24; -.
DR HGNC; HGNC:13595; FBXO24.
DR HPA; ENSG00000106336; Tissue enriched (testis).
DR MIM; 609097; gene.
DR neXtProt; NX_O75426; -.
DR OpenTargets; ENSG00000106336; -.
DR PharmGKB; PA28037; -.
DR VEuPathDB; HostDB:ENSG00000106336; -.
DR eggNOG; KOG0274; Eukaryota.
DR GeneTree; ENSGT00390000017455; -.
DR HOGENOM; CLU_032821_0_0_1; -.
DR InParanoid; O75426; -.
DR OMA; SSHDIER; -.
DR OrthoDB; 379673at2759; -.
DR PhylomeDB; O75426; -.
DR TreeFam; TF328722; -.
DR PathwayCommons; O75426; -.
DR SignaLink; O75426; -.
DR BioGRID-ORCS; 26261; 15 hits in 1110 CRISPR screens.
DR ChiTaRS; FBXO24; human.
DR GenomeRNAi; 26261; -.
DR Pharos; O75426; Tdark.
DR PRO; PR:O75426; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; O75426; protein.
DR Bgee; ENSG00000106336; Expressed in left testis and 119 other tissues.
DR ExpressionAtlas; O75426; baseline and differential.
DR Genevisible; O75426; HS.
DR GO; GO:0000151; C:ubiquitin ligase complex; NAS:UniProtKB.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; NAS:UniProtKB.
DR GO; GO:0016567; P:protein ubiquitination; NAS:UniProtKB.
DR Gene3D; 2.130.10.30; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00415; RCC1; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF50985; SSF50985; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50012; RCC1_3; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..580
FT /note="F-box only protein 24"
FT /id="PRO_0000119909"
FT DOMAIN 36..82
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 376..425
FT /note="RCC1"
FT VAR_SEQ 1..13
FT /note="MGEKAVPLLRRRR -> M (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043458"
FT VAR_SEQ 1..12
FT /note="MGEKAVPLLRRR -> MVWESQQERGGQGPRRQEGRSREGAIRMVRGSQRRK
FT LQKFTRLCGREEGL (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_043459"
FT VAR_SEQ 94..108
FT /note="GSGVRPWKRAAILNY -> D (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10531035"
FT /id="VSP_011351"
FT VAR_SEQ 319..332
FT /note="QGGVYFEVHTPGVY -> PILCSWLQPPWPGG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10531035"
FT /id="VSP_011352"
FT VAR_SEQ 333..580
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10531035"
FT /id="VSP_011353"
FT VARIANT 302
FT /note="R -> H (in dbSNP:rs7801492)"
FT /id="VAR_049042"
SQ SEQUENCE 580 AA; 64889 MW; 3863C6846AB6B940 CRC64;
MGEKAVPLLR RRRVKRSCPS CGSELGVEEK RGKGNPISIQ LFPPELVEHI ISFLPVRDLV
ALGQTCRYFH EVCDGEGVWR RICRRLSPRL QDQGSGVRPW KRAAILNYTK GLYFQAFGGR
RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL
CRGAKDFASD PRCDTVYRKY LYVLATREPQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF
HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH
LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL
FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVCYLQRPI TLWCGLNHSL
VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH
DIEQHAPYRH LPASRVVGTP EPSLGARAPQ DPGGMAQACE EYLSQIHSCQ TLQDRTEKMK
EIVGWMPLMA AQKDFFWEAL DMLQRAEGGG GGVGPPAPET
