ID   FBX24_MACFA             Reviewed;         580 AA.
AC   Q4R327;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=F-box only protein 24;
GN   Name=FBXO24; ORFNames=QtsA-20044;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; AB179441; BAE02492.1; -; mRNA.
DR   RefSeq; NP_001270026.1; NM_001283097.1.
DR   AlphaFoldDB; Q4R327; -.
DR   SMR; Q4R327; -.
DR   STRING; 9541.XP_005595573.1; -.
DR   PRIDE; Q4R327; -.
DR   Ensembl; ENSMFAT00000094116; ENSMFAP00000055439; ENSMFAG00000034514.
DR   GeneID; 101865732; -.
DR   CTD; 26261; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   GeneTree; ENSGT00390000017455; -.
DR   OrthoDB; 379673at2759; -.
DR   Proteomes; UP000233100; Chromosome 3.
DR   Bgee; ENSMFAG00000034514; Expressed in multicellular organism.
DR   Gene3D; 2.130.10.30; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00415; RCC1; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS50012; RCC1_3; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..580
FT                   /note="F-box only protein 24"
FT                   /id="PRO_0000248187"
FT   DOMAIN          36..82
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          376..425
FT                   /note="RCC1"
SQ   SEQUENCE   580 AA;  64919 MW;  B63C6D37CD72FBDA CRC64;
     MGEKAVPLLR RRRVKRSCPS CGPELGVEEK KGKGNPISIQ LFPPELVEHI ISFLPVRDLV
     ALGQTCRYFH EVCDAEGVWR RICRRLSPRL RDQGSGVRPW KRAAILNYTK GLYFQAFGGR
     RRCLSKSVAP LLAHGYRRFL PTKDHVFILD YVGTLFFLKN ALVSTLGQMQ WKRACRYVVL
     CRGAKDFASD PRCDTVYRKY LYVLATREQQ EVVGTTSSRA CDCVEVYLQS SGQRVFKMTF
     HHSMTFKQIV LVGQETQRAL LLLTEEGKIY SLVVNETQLD QPRSYTVQLA LRKVSHYLPH
     LRVACMTSNQ SSTLYVTDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDQQMP LALSLPAKIL
     FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVRYLQRPI TLWCGLNHSL
     VLSQSSEFSK ELLGCGCGAG GRLPGWPKGS ASFVKLQVKV PLCACALCAT RECLYILSSH
     DIEQHTPYRD LPASRVVGIP EPSLGTGAPQ DPGGTAQACE EYLSQIHSCH TLQDRMEKMK
     EIVGWMPLMA AQKDFFWEAL DMLQKAEGGG GGVGPPASET