ID   FBX24_MOUSE             Reviewed;         589 AA.
AC   Q9D417;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 128.
DE   RecName: Full=F-box only protein 24;
GN   Name=Fbxo24; Synonyms=Fbx24;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; AK016870; BAB30476.1; -; mRNA.
DR   CCDS; CCDS51674.1; -.
DR   RefSeq; NP_081984.1; NM_027708.1.
DR   RefSeq; XP_006504682.1; XM_006504619.3.
DR   AlphaFoldDB; Q9D417; -.
DR   SMR; Q9D417; -.
DR   BioGRID; 214532; 2.
DR   STRING; 10090.ENSMUSP00000031732; -.
DR   PhosphoSitePlus; Q9D417; -.
DR   PaxDb; Q9D417; -.
DR   PRIDE; Q9D417; -.
DR   ProteomicsDB; 267349; -.
DR   Antibodypedia; 30754; 227 antibodies from 22 providers.
DR   DNASU; 71176; -.
DR   Ensembl; ENSMUST00000031732; ENSMUSP00000031732; ENSMUSG00000089984.
DR   GeneID; 71176; -.
DR   KEGG; mmu:71176; -.
DR   UCSC; uc009adc.1; mouse.
DR   CTD; 26261; -.
DR   MGI; MGI:1918426; Fbxo24.
DR   VEuPathDB; HostDB:ENSMUSG00000089984; -.
DR   eggNOG; KOG0274; Eukaryota.
DR   GeneTree; ENSGT00390000017455; -.
DR   InParanoid; Q9D417; -.
DR   OMA; SSHDIER; -.
DR   OrthoDB; 379673at2759; -.
DR   PhylomeDB; Q9D417; -.
DR   TreeFam; TF328722; -.
DR   BioGRID-ORCS; 71176; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Fbxo24; mouse.
DR   PRO; PR:Q9D417; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q9D417; protein.
DR   Bgee; ENSMUSG00000089984; Expressed in spermatid and 24 other tissues.
DR   ExpressionAtlas; Q9D417; baseline and differential.
DR   Genevisible; Q9D417; MM.
DR   Gene3D; 2.130.10.30; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF00415; RCC1; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS50012; RCC1_3; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..589
FT                   /note="F-box only protein 24"
FT                   /id="PRO_0000119910"
FT   DOMAIN          23..69
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          386..435
FT                   /note="RCC1"
FT   REGION          506..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   589 AA;  65429 MW;  F4FB50703BD4D270 CRC64;
     MVKRSCPSCG LEAGSEKKER GNPISVQLFP PELVEHIVSF LPVKDLVALG QTCHYFHEVC
     DAEGVWRRIC RRLSPRIRDQ SSGARPWKRA AILNYTKGLY FQAFGGRRRC LSKSVAPMLA
     HGYRRFLPTK DHVFILDYVG TLFFLKNALV SSTLGQIQWK RACRYVVLCR GAKDFASDPR
     CDTVYRKYLY VLATREQPAV VGTTGSRACD CVEVYLQSSG QRVFKMTFHH SMSFKQIVLV
     GQETQRALLL LTEEGKIYSL VVNETQLDQP RSYTVQLALR KVSRCLPHLR VTCMASNQSS
     TLYITGGTLI PRKQVPKAAE LRAPDPPDQG GVYFEVHTPG VYRDLFGTLQ AFDPLDHQMP
     LALSLPAKVL FCALGYNHLG LVDEFGRIFM QGNNRYGQLG TGDKMDRGEP TQVHYLQRPI
     ALWCGLNHSL VLSQTSDFSK ELLGCGCGAG GRLPGWPKGS ASFVKLHIKV PLCACSLCST
     RECLYMLSSH DIEQCPVYRD LPASRVGGSP EPSQGAGAPQ DPGGTAQACE EYLSQIHSCP
     TLQDRMEKMK EIVGWMPLMA AQKDFFWEAL DMLQRAAGGA GPDTSTPES