ID   FBX25_BOVIN             Reviewed;         357 AA.
AC   Q1RMS8;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=F-box only protein 25;
GN   Name=FBXO25;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. May play a role in
CC       accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT)
CC       (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex
CC       consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1
CC       and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=In the nucleus,
CC       associates with subnuclear dot-like structure. {ECO:0000250}.
CC   -!- DOMAIN: The F-box is necessary for the interaction with SKP1.
CC       {ECO:0000250}.
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DR   EMBL; BC114733; AAI14734.1; -; mRNA.
DR   RefSeq; NP_001069679.1; NM_001076211.1.
DR   AlphaFoldDB; Q1RMS8; -.
DR   SMR; Q1RMS8; -.
DR   STRING; 9913.ENSBTAP00000009259; -.
DR   PaxDb; Q1RMS8; -.
DR   PRIDE; Q1RMS8; -.
DR   Ensembl; ENSBTAT00000009259; ENSBTAP00000009259; ENSBTAG00000007039.
DR   GeneID; 540328; -.
DR   KEGG; bta:540328; -.
DR   CTD; 26260; -.
DR   VEuPathDB; HostDB:ENSBTAG00000007039; -.
DR   VGNC; VGNC:28900; FBXO25.
DR   eggNOG; KOG3926; Eukaryota.
DR   GeneTree; ENSGT00390000004915; -.
DR   HOGENOM; CLU_065667_0_0_1; -.
DR   InParanoid; Q1RMS8; -.
DR   OrthoDB; 623008at2759; -.
DR   TreeFam; TF313070; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 1.
DR   Bgee; ENSBTAG00000007039; Expressed in adenohypophysis and 104 other tissues.
DR   ExpressionAtlas; Q1RMS8; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR040394; FBX25/32.
DR   PANTHER; PTHR13123; PTHR13123; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..357
FT                   /note="F-box only protein 25"
FT                   /id="PRO_0000284974"
FT   DOMAIN          225..273
FT                   /note="F-box"
FT   REGION          1..83
FT                   /note="Interaction with beta-actin"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   357 AA;  41834 MW;  F51AA1B1DD639828 CRC64;
     MPFLGQDWRS PGWSWMKTED GWKRCDAWSQ ELEGENSQCD IGHGIILNSE DEEIFSNEEH
     EFASKKRKKD HFRNDTNTQC FYRENWIYVH KESTRERHGY CTLGEAFNRL DFSSAIQDIR
     RFNYVVRLLQ LIAKSQLTSL SGVAQKNYFN ILDKIVQKVL GDHQNPRLIK DLLQDLSSTL
     CILIRGVGKS VLVGNINIWI CRLETVLRWQ QQLQNLQMTE VDSGLTLSDL PVHMLSNILY
     RFSDGWDIVT LGQVTPTLSA LSEDRQLWKK LCQYHFGEKQ FCRHLILSEK GHVEWKLMYF
     ALQKHYPTKE QYGDTLHFCR HCSILFWKDS GHPCTAADPD SCFTPVSPQH FIDLFKY