ID   FBX25_MACFA             Reviewed;         358 AA.
AC   Q4R372;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=F-box only protein 25;
GN   Name=FBXO25; ORFNames=QtsA-19104;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. May play a role in
CC       accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT)
CC       (By similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex
CC       consisting of FBXO25, SKP1, CUL1 and RBX1. Interacts directly with SKP1
CC       and CUL1. Interacts (via C-terminus) with beta-actin (via N-terminus).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=In the nucleus,
CC       associates with a subnuclear dot-like structure. {ECO:0000250}.
CC   -!- DOMAIN: The F-box is necessary for the interaction with SKP1.
CC       {ECO:0000250}.
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DR   EMBL; AB179395; BAE02446.1; -; mRNA.
DR   RefSeq; NP_001271799.1; NM_001284870.1.
DR   RefSeq; XP_005562553.1; XM_005562496.2.
DR   RefSeq; XP_015309836.1; XM_015454350.1.
DR   AlphaFoldDB; Q4R372; -.
DR   STRING; 9541.XP_005562547.1; -.
DR   Ensembl; ENSMFAT00000002415; ENSMFAP00000028226; ENSMFAG00000045462.
DR   GeneID; 101866427; -.
DR   KEGG; mcf:101866427; -.
DR   CTD; 26260; -.
DR   VEuPathDB; HostDB:ENSMFAG00000045462; -.
DR   eggNOG; KOG3926; Eukaryota.
DR   GeneTree; ENSGT00390000004915; -.
DR   OMA; CTSMSEA; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000233100; Chromosome 8.
DR   Bgee; ENSMFAG00000045462; Expressed in thymus and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR040394; FBX25/32.
DR   PANTHER; PTHR13123; PTHR13123; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..358
FT                   /note="F-box only protein 25"
FT                   /id="PRO_0000278286"
FT   DOMAIN          226..274
FT                   /note="F-box"
FT   REGION          1..83
FT                   /note="Interaction with beta-actin"
SQ   SEQUENCE   358 AA;  42192 MW;  00BBD5AF16B2CD3E CRC64;
     MPFLGQDWRS PGWSWIKTED GWKRCESCSQ KLERENNHCN ISHSIILNSE DGEIFNNEEH
     EYASKKRKKD HFRNDTNTQS FYREKWIYVH KESTKERHGY CTLGEAFNRL DFSSAIQDIR
     RFNYVVKLLQ LIAKSQLTSL SGVAQKNYFN ILDKIVQKVL DDHHNPRLIK DLLQDLSSTL
     CILIRGVGKS VLVGNINIWI CRLETILAWQ QQLQDLQMTK QVNNGLTLSD LPLHMLNNIL
     YRFSDGWDII TLGQVTPTLY MLSEDRQLWK KLCQYHFAEK QFCRHLILSE KGHIEWKLMY
     FALQKHYPAK EQYGDTLHFC RHCSILFWKD SGHPCTAADP DSCFTPVSPQ HFIDLFKF