ID   FBX27_MACFA             Reviewed;         280 AA.
AC   Q9N0C8;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=F-box only protein 27;
GN   Name=FBXO27; ORFNames=QccE-12959;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RX   PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA   Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT   "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT   chromosomes.";
RL   Gene 275:31-37(2001).
RN   [2]
RP   ERRATUM OF PUBMED:11574149.
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA   Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL   Gene 278:267-267(2001).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Able to recognize and bind
CC       complex-type oligosaccharides. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       Interacts with SKP1 and CUL1 (By similarity). {ECO:0000250}.
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DR   EMBL; AB046002; BAB01584.1; -; mRNA.
DR   RefSeq; NP_001270953.1; NM_001284024.1.
DR   AlphaFoldDB; Q9N0C8; -.
DR   SMR; Q9N0C8; -.
DR   GeneID; 101865596; -.
DR   CTD; 126433; -.
DR   eggNOG; ENOG502RZA6; Eukaryota.
DR   OrthoDB; 922544at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   InterPro; IPR007397; F-box-assoc_dom.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039752; F-box_only.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12125; PTHR12125; 1.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF04300; FBA; 1.
DR   SMART; SM01198; FBA; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS51114; FBA; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..280
FT                   /note="F-box only protein 27"
FT                   /id="PRO_0000119915"
FT   DOMAIN          25..72
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          100..277
FT                   /note="FBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  31379 MW;  F2018F7306789F26 CRC64;
     MGAWASRGRA ARVPAPEPES EPEEALDLSQ LPPELLLVVL SHVPPRTLLG RCRQVCRGWR
     ALVDGQALWL LILARDHSAT GRALLHLARS CQSPARNARP CPLGRFCARR PIGRNPCGQG
     LRKWMVQHGG DGWVVEENRT TVPGAPSQTC FVTSFSWCRK KQVLDLEEEG LWPELLDSGR
     IEICVSDWWG ARHDSGCMYR LLVQLLDANQ TVLDKFSAVP DPIPQWNNNA CLHVTHVFSN
     IKMGVRFVSF EHWGQDTQFW AGHYGARVTN SSVIVRVHLS