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FBX27_MOUSE
ID   FBX27_MOUSE             Reviewed;         280 AA.
AC   Q6DIA9; Q3TYP0; Q8BKF7;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=F-box only protein 27;
GN   Name=Fbxo27;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J; TISSUE=Corpora quadrigemina, Eye, and Inner ear;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J; TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=18203720; DOI=10.1074/jbc.m709508200;
RA   Glenn K.A., Nelson R.F., Wen H.M., Mallinger A.J., Paulson H.L.;
RT   "Diversity in tissue expression, substrate binding, and SCF complex
RT   formation for a lectin family of ubiquitin ligases.";
RL   J. Biol. Chem. 283:12717-12729(2008).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Able to recognize and bind
CC       complex-type oligosaccharides. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       Interacts with SKP1 and CUL1 (By similarity). {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q6DIA9-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q6DIA9-2; Sequence=VSP_013054;
CC   -!- TISSUE SPECIFICITY: Detected in brain, heart and muscle.
CC       {ECO:0000269|PubMed:18203720}.
CC   -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC       site. {ECO:0000305}.
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DR   EMBL; AK053292; BAC35334.1; -; mRNA.
DR   EMBL; AK140275; BAE24311.1; -; mRNA.
DR   EMBL; AK158463; BAE34522.1; -; mRNA.
DR   EMBL; BC075656; AAH75656.1; -; mRNA.
DR   CCDS; CCDS21051.1; -. [Q6DIA9-2]
DR   CCDS; CCDS52164.1; -. [Q6DIA9-1]
DR   RefSeq; NP_001157174.1; NM_001163702.1. [Q6DIA9-1]
DR   RefSeq; NP_997121.1; NM_207238.3. [Q6DIA9-2]
DR   RefSeq; XP_006539929.1; XM_006539866.1.
DR   RefSeq; XP_006539930.1; XM_006539867.3. [Q6DIA9-1]
DR   AlphaFoldDB; Q6DIA9; -.
DR   SMR; Q6DIA9; -.
DR   STRING; 10090.ENSMUSP00000103916; -.
DR   PhosphoSitePlus; Q6DIA9; -.
DR   PaxDb; Q6DIA9; -.
DR   PRIDE; Q6DIA9; -.
DR   ProteomicsDB; 267578; -. [Q6DIA9-1]
DR   ProteomicsDB; 267579; -. [Q6DIA9-2]
DR   Antibodypedia; 30249; 133 antibodies from 22 providers.
DR   DNASU; 233040; -.
DR   Ensembl; ENSMUST00000039998; ENSMUSP00000038432; ENSMUSG00000037463. [Q6DIA9-2]
DR   Ensembl; ENSMUST00000108281; ENSMUSP00000103916; ENSMUSG00000037463. [Q6DIA9-1]
DR   GeneID; 233040; -.
DR   KEGG; mmu:233040; -.
DR   UCSC; uc009fzk.2; mouse. [Q6DIA9-1]
DR   UCSC; uc012fgv.1; mouse. [Q6DIA9-2]
DR   CTD; 126433; -.
DR   MGI; MGI:2685007; Fbxo27.
DR   VEuPathDB; HostDB:ENSMUSG00000037463; -.
DR   eggNOG; ENOG502RZA6; Eukaryota.
DR   GeneTree; ENSGT00940000161841; -.
DR   HOGENOM; CLU_068548_0_0_1; -.
DR   InParanoid; Q6DIA9; -.
DR   OMA; NNVCLHV; -.
DR   OrthoDB; 922544at2759; -.
DR   PhylomeDB; Q6DIA9; -.
DR   TreeFam; TF320527; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   BioGRID-ORCS; 233040; 2 hits in 72 CRISPR screens.
DR   PRO; PR:Q6DIA9; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q6DIA9; protein.
DR   Bgee; ENSMUSG00000037463; Expressed in retinal neural layer and 129 other tissues.
DR   ExpressionAtlas; Q6DIA9; baseline and differential.
DR   Genevisible; Q6DIA9; MM.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
DR   GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:GOC.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR   InterPro; IPR007397; F-box-assoc_dom.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039752; F-box_only.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   PANTHER; PTHR12125; PTHR12125; 1.
DR   Pfam; PF00646; F-box; 1.
DR   Pfam; PF04300; FBA; 1.
DR   SMART; SM01198; FBA; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF49785; SSF49785; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS51114; FBA; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..280
FT                   /note="F-box only protein 27"
FT                   /id="PRO_0000119916"
FT   DOMAIN          20..67
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          101..277
FT                   /note="FBA"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
FT   VAR_SEQ         119
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_013054"
SQ   SEQUENCE   280 AA;  31633 MW;  36FF90947DFAE86B CRC64;
     MGAWISRTRV PTPEPDPQEV LDLSRLPPEL LLLVLSHVPP RTLLMHCRRV CRAWRALVDG
     QALWLLLLAR DHSAAGRALL TLARRCLPPA HEDTPCPLGQ FCALRPLGRN LISNPCGQEG
     LRKWMVRHGG DGWVVEKNRK PVPGAPSQTC FVTSFSWCRK KQVVDLVEKG LWPELLDSGG
     VEIAVSDWWG ARHDSGCKYR LFVTLLDAHQ NVIDKFSAVP DPIEQWNNDI YLQVTHVFSG
     IRRGIRFVSF EHWGQDTQFW AGHYGARVTN SSVIIRVCQS
 
 
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