ID   FBX28_BOVIN             Reviewed;         368 AA.
AC   Q2NL16;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=F-box only protein 28;
GN   Name=FBXO28;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC       and promotes their ubiquitination and degradation. {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250|UniProtKB:Q9NVF7}.
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DR   EMBL; BC111213; AAI11214.1; -; mRNA.
DR   RefSeq; NP_001039890.1; NM_001046425.1.
DR   AlphaFoldDB; Q2NL16; -.
DR   SMR; Q2NL16; -.
DR   STRING; 9913.ENSBTAP00000026033; -.
DR   PaxDb; Q2NL16; -.
DR   PRIDE; Q2NL16; -.
DR   Ensembl; ENSBTAT00000026033; ENSBTAP00000026033; ENSBTAG00000019538.
DR   GeneID; 537745; -.
DR   KEGG; bta:537745; -.
DR   CTD; 23219; -.
DR   VEuPathDB; HostDB:ENSBTAG00000019538; -.
DR   VGNC; VGNC:28901; FBXO28.
DR   eggNOG; ENOG502QT70; Eukaryota.
DR   GeneTree; ENSGT00390000002970; -.
DR   HOGENOM; CLU_024146_1_1_1; -.
DR   InParanoid; Q2NL16; -.
DR   OMA; DCLRKSK; -.
DR   OrthoDB; 798303at2759; -.
DR   TreeFam; TF324672; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000019538; Expressed in granulosa cell and 110 other tissues.
DR   ExpressionAtlas; Q2NL16; baseline.
DR   GO; GO:0000776; C:kinetochore; ISS:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039719; FBXO28.
DR   PANTHER; PTHR13252; PTHR13252; 1.
DR   Pfam; PF00646; F-box; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Centromere; Chromosome; Kinetochore; Phosphoprotein; Reference proteome;
KW   Ubl conjugation pathway.
FT   CHAIN           1..368
FT                   /note="F-box only protein 28"
FT                   /id="PRO_0000259957"
FT   DOMAIN          61..109
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REGION          1..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          328..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..55
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..360
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         235
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVF7"
FT   MOD_RES         242
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVF7"
FT   MOD_RES         270
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVF7"
FT   MOD_RES         344
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NVF7"
SQ   SEQUENCE   368 AA;  41096 MW;  D37CBFD647C84362 CRC64;
     MAAASEERMA EEGGGGHGDG GSPSAIASTQ RLPPPPPPQP PQPGSQAPPA PALAPDQLPQ
     NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV
     KAQLPRRESE RRNHSLARHA DILAAVETRL SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV
     LRYVNSTRAP QRAHEVLQEL RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG
     PSAALTTMQL FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
     QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ SEESPRKRKK AAEAIDSLRK
     SKRLRNRK