FBX28_HUMAN
ID FBX28_HUMAN Reviewed; 368 AA.
AC Q9NVF7; E9PEM8; O75070;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=F-box only protein 28;
GN Name=FBXO28; Synonyms=CENP-30 {ECO:0000303|PubMed:20813266}, KIAA0483;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 70-368 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=9455484; DOI=10.1093/dnares/4.5.345;
RA Seki N., Ohira M., Nagase T., Ishikawa K., Miyajima N., Nakajima D.,
RA Nomura N., Ohara O.;
RT "Characterization of cDNA clones in size-fractionated cDNA libraries from
RT human brain.";
RL DNA Res. 4:345-349(1997).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-235 AND SER-344, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [9]
RP SUBCELLULAR LOCATION.
RX PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L., Wood L.,
RA Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P., Fukagawa T.,
RA Earnshaw W.C., Rappsilber J.;
RT "The protein composition of mitotic chromosomes determined using
RT multiclassifier combinatorial proteomics.";
RL Cell 142:810-821(2010).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-242; THR-270 AND SER-344, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-344, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP VARIANT HIS-345.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC and promotes their ubiquitination and degradation. {ECO:0000250}.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NVF7; Q8N302: AGGF1; NbExp=3; IntAct=EBI-740282, EBI-747899;
CC Q9NVF7; Q6NZI2: CAVIN1; NbExp=4; IntAct=EBI-740282, EBI-2559016;
CC Q9NVF7; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-740282, EBI-11962928;
CC Q9NVF7; Q9Y6C2-2: EMILIN1; NbExp=3; IntAct=EBI-740282, EBI-11748557;
CC Q9NVF7; Q9NT22: EMILIN3; NbExp=6; IntAct=EBI-740282, EBI-3197883;
CC Q9NVF7; Q9UPT5-1: EXOC7; NbExp=3; IntAct=EBI-740282, EBI-6251402;
CC Q9NVF7; Q9NVF7: FBXO28; NbExp=3; IntAct=EBI-740282, EBI-740282;
CC Q9NVF7; Q96CN9: GCC1; NbExp=3; IntAct=EBI-740282, EBI-746252;
CC Q9NVF7; Q08379: GOLGA2; NbExp=7; IntAct=EBI-740282, EBI-618309;
CC Q9NVF7; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-740282, EBI-5916454;
CC Q9NVF7; Q9NSC5: HOMER3; NbExp=5; IntAct=EBI-740282, EBI-748420;
CC Q9NVF7; Q9H8W4: PLEKHF2; NbExp=6; IntAct=EBI-740282, EBI-742388;
CC Q9NVF7; Q6P1K2: PMF1; NbExp=4; IntAct=EBI-740282, EBI-713832;
CC Q9NVF7; P17980: PSMC3; NbExp=4; IntAct=EBI-740282, EBI-359720;
CC Q9NVF7; Q9H190: SDCBP2; NbExp=6; IntAct=EBI-740282, EBI-742426;
CC Q9NVF7; P63208: SKP1; NbExp=11; IntAct=EBI-740282, EBI-307486;
CC Q9NVF7; Q96R06: SPAG5; NbExp=3; IntAct=EBI-740282, EBI-413317;
CC Q9NVF7; P61266: STX1B; NbExp=3; IntAct=EBI-740282, EBI-9071709;
CC Q9NVF7; Q12933: TRAF2; NbExp=7; IntAct=EBI-740282, EBI-355744;
CC Q9NVF7; O00463: TRAF5; NbExp=4; IntAct=EBI-740282, EBI-523498;
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000269|PubMed:20813266}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NVF7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NVF7-2; Sequence=VSP_047265, VSP_047266;
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DR EMBL; AK001628; BAA91795.1; -; mRNA.
DR EMBL; AL390122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031576; AAH31576.1; -; mRNA.
DR EMBL; AB007952; BAA32327.1; -; mRNA.
DR CCDS; CCDS1539.1; -. [Q9NVF7-1]
DR CCDS; CCDS44320.1; -. [Q9NVF7-2]
DR RefSeq; NP_001129587.1; NM_001136115.2. [Q9NVF7-2]
DR RefSeq; NP_055991.1; NM_015176.3. [Q9NVF7-1]
DR AlphaFoldDB; Q9NVF7; -.
DR SMR; Q9NVF7; -.
DR BioGRID; 116826; 93.
DR DIP; DIP-56683N; -.
DR IntAct; Q9NVF7; 62.
DR MINT; Q9NVF7; -.
DR STRING; 9606.ENSP00000355827; -.
DR iPTMnet; Q9NVF7; -.
DR PhosphoSitePlus; Q9NVF7; -.
DR BioMuta; FBXO28; -.
DR DMDM; 59797970; -.
DR EPD; Q9NVF7; -.
DR jPOST; Q9NVF7; -.
DR MassIVE; Q9NVF7; -.
DR MaxQB; Q9NVF7; -.
DR PaxDb; Q9NVF7; -.
DR PeptideAtlas; Q9NVF7; -.
DR PRIDE; Q9NVF7; -.
DR ProteomicsDB; 19924; -.
DR ProteomicsDB; 82789; -. [Q9NVF7-1]
DR Antibodypedia; 34636; 192 antibodies from 26 providers.
DR DNASU; 23219; -.
DR Ensembl; ENST00000366862.10; ENSP00000355827.5; ENSG00000143756.12. [Q9NVF7-1]
DR Ensembl; ENST00000424254.6; ENSP00000416888.2; ENSG00000143756.12. [Q9NVF7-2]
DR GeneID; 23219; -.
DR KEGG; hsa:23219; -.
DR MANE-Select; ENST00000366862.10; ENSP00000355827.5; NM_015176.4; NP_055991.1.
DR UCSC; uc001hoh.3; human. [Q9NVF7-1]
DR CTD; 23219; -.
DR DisGeNET; 23219; -.
DR GeneCards; FBXO28; -.
DR HGNC; HGNC:29046; FBXO28.
DR HPA; ENSG00000143756; Low tissue specificity.
DR MIM; 609100; gene.
DR neXtProt; NX_Q9NVF7; -.
DR OpenTargets; ENSG00000143756; -.
DR PharmGKB; PA134876528; -.
DR VEuPathDB; HostDB:ENSG00000143756; -.
DR eggNOG; ENOG502QT70; Eukaryota.
DR GeneTree; ENSGT00390000002970; -.
DR HOGENOM; CLU_024146_1_1_1; -.
DR InParanoid; Q9NVF7; -.
DR OMA; DCLRKSK; -.
DR PhylomeDB; Q9NVF7; -.
DR TreeFam; TF324672; -.
DR PathwayCommons; Q9NVF7; -.
DR SignaLink; Q9NVF7; -.
DR BioGRID-ORCS; 23219; 52 hits in 1122 CRISPR screens.
DR ChiTaRS; FBXO28; human.
DR GeneWiki; FBXO28; -.
DR GenomeRNAi; 23219; -.
DR Pharos; Q9NVF7; Tbio.
DR PRO; PR:Q9NVF7; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9NVF7; protein.
DR Bgee; ENSG00000143756; Expressed in hair follicle and 201 other tissues.
DR ExpressionAtlas; Q9NVF7; baseline and differential.
DR Genevisible; Q9NVF7; HS.
DR GO; GO:0000776; C:kinetochore; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0000209; P:protein polyubiquitination; IBA:GO_Central.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039719; FBXO28.
DR PANTHER; PTHR13252; PTHR13252; 1.
DR Pfam; PF00646; F-box; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Centromere; Chromosome; Kinetochore; Phosphoprotein;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..368
FT /note="F-box only protein 28"
FT /id="PRO_0000119917"
FT DOMAIN 61..109
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 1..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..45
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 235
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 242
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 270
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 344
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17081983,
FT ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT VAR_SEQ 173..179
FT /note="VIDEIYR -> FQDRLQP (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047265"
FT VAR_SEQ 180..368
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047266"
FT VARIANT 345
FT /note="P -> H (found in a renal cell carcinoma case;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064713"
SQ SEQUENCE 368 AA; 41149 MW; 500A2583AB7315E6 CRC64;
MAAAAEERMA EEGGGGQGDG GSSLASGSTQ RQPPPPAPQH PQPGSQALPA PALAPDQLPQ
NNTLVALPIV AIENILSFMS YDEISQLRLV CKRMDLVCQR MLNQGFLKVE RYHNLCQKQV
KAQLPRRESE RRNHSLARHA DILAAVETRL SLLNMTFMKY VDSNLCCFIP GKVIDEIYRV
LRYVNSTRAP QRAHEVLQEL RDISSMAMEY FDEKIVPILK RKLPGSDVSG RLMGSPPVPG
PSAALTTMQL FSKQNPSRQE VTKLQQQVKT NGAGVTVLRR EISELRTKVQ EQQKQLQDQD
QKLLEQTQII GEQNARLAEL ERKLREVMES AVGNSSGSGQ NEESPRKRKK ATEAIDSLRK
SKRLRNRK