ID   FBX32_BOVIN             Reviewed;         355 AA.
AC   Q2KHT6;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=F-box only protein 32;
GN   Name=FBXO32;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. Probably recognizes and binds to phosphorylated target
CC       proteins during skeletal muscle atrophy. Recognizes TERF1 (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.
CC       {ECO:0000250|UniProtKB:Q969P5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969P5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q969P5}. Note=Shuttles between cytoplasm and the
CC       nucleus. {ECO:0000250|UniProtKB:Q969P5}.
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DR   EMBL; BC112888; AAI12889.1; -; mRNA.
DR   RefSeq; NP_001039620.1; NM_001046155.1.
DR   AlphaFoldDB; Q2KHT6; -.
DR   STRING; 9913.ENSBTAP00000021554; -.
DR   PaxDb; Q2KHT6; -.
DR   PRIDE; Q2KHT6; -.
DR   Ensembl; ENSBTAT00000021554; ENSBTAP00000021554; ENSBTAG00000016194.
DR   GeneID; 513776; -.
DR   KEGG; bta:513776; -.
DR   CTD; 114907; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016194; -.
DR   VGNC; VGNC:28905; FBXO32.
DR   eggNOG; KOG3926; Eukaryota.
DR   GeneTree; ENSGT00390000004915; -.
DR   HOGENOM; CLU_065667_0_0_1; -.
DR   InParanoid; Q2KHT6; -.
DR   OMA; QNWVKTE; -.
DR   OrthoDB; 623008at2759; -.
DR   TreeFam; TF313070; -.
DR   Reactome; R-BTA-8951664; Neddylation.
DR   Reactome; R-BTA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000016194; Expressed in longissimus thoracis muscle and 109 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0014894; P:response to denervation involved in regulation of muscle adaptation; ISS:UniProtKB.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR040394; FBX25/32.
DR   PANTHER; PTHR13123; PTHR13123; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..355
FT                   /note="F-box only protein 32"
FT                   /id="PRO_0000244593"
FT   DOMAIN          223..271
FT                   /note="F-box"
FT   MOTIF           62..67
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           169..173
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           280..295
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   355 AA;  41595 MW;  C237131A1B23D2C4 CRC64;
     MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GSFVSDLGSY CSKEVYNKEN LFNSLNYDVA
     AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN
     YVVRLLELIA KSQLTSLSGI AQKNFMNILE KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL
     VQRVGKSVLV GNINMWVYRM ETILHWQQQL NNIQITRPAF KGLTFTDLPL CLQLNIMQRL
     SDGRDLVSLG QVAPDLHVLS EDRLLWKKLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL
     ARCYPRKEQY GDTLQLCRHC HILSWKGTDH PCTANNPESC SISLSPQDFI NLFKF