ID   FBX32_PIG               Reviewed;         355 AA.
AC   Q1A730;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=F-box only protein 32;
GN   Name=FBXO32;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yu J., Zhu M.J., Liu B., Fan B., Li C.C., Zhao S.H.;
RT   "Polymorphism analysis of the porcine FBXO 32.";
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC       protein) E3 ubiquitin-protein ligase complex which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. Probably recognizes and binds to phosphorylated target
CC       proteins during skeletal muscle atrophy. Recognizes TERF1 (By
CC       similarity). {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC       complex SCF(FBXO32) formed of CUL1, SKP1, RBX1 and FBXO32.
CC       {ECO:0000250|UniProtKB:Q969P5}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q969P5}. Nucleus
CC       {ECO:0000250|UniProtKB:Q969P5}. Note=Shuttles between cytoplasm and the
CC       nucleus. {ECO:0000250|UniProtKB:Q969P5}.
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DR   EMBL; DQ288235; ABC47657.1; -; mRNA.
DR   RefSeq; NP_001038053.1; NM_001044588.1.
DR   AlphaFoldDB; Q1A730; -.
DR   STRING; 9823.ENSSSCP00000006389; -.
DR   PaxDb; Q1A730; -.
DR   PRIDE; Q1A730; -.
DR   Ensembl; ENSSSCT00000044541; ENSSSCP00000035710; ENSSSCG00000005981.
DR   Ensembl; ENSSSCT00005049050; ENSSSCP00005030274; ENSSSCG00005030776.
DR   Ensembl; ENSSSCT00015110400; ENSSSCP00015047162; ENSSSCG00015081012.
DR   Ensembl; ENSSSCT00025053789; ENSSSCP00025022915; ENSSSCG00025039530.
DR   Ensembl; ENSSSCT00030076910; ENSSSCP00030035110; ENSSSCG00030055185.
DR   Ensembl; ENSSSCT00035056942; ENSSSCP00035022904; ENSSSCG00035042848.
DR   Ensembl; ENSSSCT00040081035; ENSSSCP00040035166; ENSSSCG00040059594.
DR   Ensembl; ENSSSCT00045030665; ENSSSCP00045021257; ENSSSCG00045017934.
DR   Ensembl; ENSSSCT00050017399; ENSSSCP00050007173; ENSSSCG00050012882.
DR   Ensembl; ENSSSCT00055025119; ENSSSCP00055019958; ENSSSCG00055012753.
DR   Ensembl; ENSSSCT00060020401; ENSSSCP00060008350; ENSSSCG00060015331.
DR   Ensembl; ENSSSCT00065094399; ENSSSCP00065041283; ENSSSCG00065068772.
DR   Ensembl; ENSSSCT00070011138; ENSSSCP00070009180; ENSSSCG00070005842.
DR   GeneID; 733657; -.
DR   KEGG; ssc:733657; -.
DR   CTD; 114907; -.
DR   VGNC; VGNC:88039; FBXO32.
DR   eggNOG; KOG3926; Eukaryota.
DR   GeneTree; ENSGT00390000004915; -.
DR   InParanoid; Q1A730; -.
DR   OMA; QNWVKTE; -.
DR   OrthoDB; 623008at2759; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000008227; Chromosome 4.
DR   Proteomes; UP000314985; Chromosome 4.
DR   Bgee; ENSSSCG00000005981; Expressed in psoas major muscle and 45 other tissues.
DR   ExpressionAtlas; Q1A730; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; ISS:UniProtKB.
DR   GO; GO:0014894; P:response to denervation involved in regulation of muscle adaptation; ISS:UniProtKB.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR040394; FBX25/32.
DR   PANTHER; PTHR13123; PTHR13123; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..355
FT                   /note="F-box only protein 32"
FT                   /id="PRO_0000262916"
FT   DOMAIN          223..271
FT                   /note="F-box"
FT   MOTIF           62..67
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           169..173
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           280..295
FT                   /note="Bipartite nuclear localization signal"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   355 AA;  41666 MW;  3EE4A1771094784D CRC64;
     MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GSFVSDLSSY CNKEVYNKEN LFNSLNYDVA
     AKKRKKDMLN SKTKTQYFHQ EKWIYVHKGS TKERHGYCTL GEAFNRLDFS TAILDSRRFN
     YVVRLLELIA KSQLTSLSGI AQKNFMNILE KVVLKVLEDQ QNIRLIRELL QTLYTSLCTL
     VQRVGKSVLV GNINMWVYRM ETILHWQQQL NNIQITRPAF KGLTFTDLPL CLQLNIMQRL
     SDGRDLVSLG QVAPDLHVLS EDRLLWKKLC QYHFSERQIR KRLILSDKGQ LDWKKMYFKL
     VRCYPRKEQY GDTLQLCRHC HILSWKGTDH PCTANNPESC SVSLSPQDFI NLFKF