FBX33_HUMAN
ID FBX33_HUMAN Reviewed; 555 AA.
AC Q7Z6M2; Q6PIR2; Q86TR2; Q86YE0;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=F-box only protein 33;
GN Name=FBXO33; Synonyms=FBX33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Skin, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-346.
RC TISSUE=Placenta;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC protein) E3 ubiquitin-protein ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. Probably recognizes and binds to phosphorylated target
CC proteins. Recognizes YBX1 (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts
CC via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1
CC and CUL1 (By similarity). {ECO:0000250}.
CC -!- INTERACTION:
CC Q7Z6M2; Q13616: CUL1; NbExp=2; IntAct=EBI-8555452, EBI-359390;
CC Q7Z6M2; P63208: SKP1; NbExp=2; IntAct=EBI-8555452, EBI-307486;
CC Q7Z6M2; P67809: YBX1; NbExp=6; IntAct=EBI-8555452, EBI-354065;
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DR EMBL; BC030611; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC042535; AAH42535.1; -; mRNA.
DR EMBL; BC053537; AAH53537.1; -; mRNA.
DR EMBL; BC068566; AAH68566.1; -; mRNA.
DR EMBL; BX248772; CAD66579.1; -; mRNA.
DR CCDS; CCDS9677.1; -.
DR RefSeq; NP_976046.1; NM_203301.3.
DR AlphaFoldDB; Q7Z6M2; -.
DR BioGRID; 129019; 20.
DR IntAct; Q7Z6M2; 13.
DR MINT; Q7Z6M2; -.
DR STRING; 9606.ENSP00000298097; -.
DR iPTMnet; Q7Z6M2; -.
DR PhosphoSitePlus; Q7Z6M2; -.
DR BioMuta; FBXO33; -.
DR DMDM; 51315939; -.
DR EPD; Q7Z6M2; -.
DR jPOST; Q7Z6M2; -.
DR MassIVE; Q7Z6M2; -.
DR MaxQB; Q7Z6M2; -.
DR PaxDb; Q7Z6M2; -.
DR PeptideAtlas; Q7Z6M2; -.
DR PRIDE; Q7Z6M2; -.
DR ProteomicsDB; 69446; -.
DR Antibodypedia; 23412; 79 antibodies from 17 providers.
DR DNASU; 254170; -.
DR Ensembl; ENST00000298097.8; ENSP00000298097.7; ENSG00000165355.8.
DR GeneID; 254170; -.
DR KEGG; hsa:254170; -.
DR MANE-Select; ENST00000298097.8; ENSP00000298097.7; NM_203301.4; NP_976046.1.
DR UCSC; uc001wvk.4; human.
DR CTD; 254170; -.
DR DisGeNET; 254170; -.
DR GeneCards; FBXO33; -.
DR HGNC; HGNC:19833; FBXO33.
DR HPA; ENSG00000165355; Tissue enhanced (bone).
DR MIM; 609103; gene.
DR neXtProt; NX_Q7Z6M2; -.
DR OpenTargets; ENSG00000165355; -.
DR PharmGKB; PA134861757; -.
DR VEuPathDB; HostDB:ENSG00000165355; -.
DR eggNOG; ENOG502QPU4; Eukaryota.
DR GeneTree; ENSGT00390000017718; -.
DR HOGENOM; CLU_042932_0_0_1; -.
DR InParanoid; Q7Z6M2; -.
DR OMA; YPALWTE; -.
DR OrthoDB; 451668at2759; -.
DR PhylomeDB; Q7Z6M2; -.
DR TreeFam; TF321665; -.
DR PathwayCommons; Q7Z6M2; -.
DR SignaLink; Q7Z6M2; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 254170; 11 hits in 1121 CRISPR screens.
DR ChiTaRS; FBXO33; human.
DR GenomeRNAi; 254170; -.
DR Pharos; Q7Z6M2; Tdark.
DR PRO; PR:Q7Z6M2; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q7Z6M2; protein.
DR Bgee; ENSG00000165355; Expressed in secondary oocyte and 186 other tissues.
DR ExpressionAtlas; Q7Z6M2; baseline and differential.
DR Genevisible; Q7Z6M2; HS.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039940; FBXO33.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR20933; PTHR20933; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..555
FT /note="F-box only protein 33"
FT /id="PRO_0000119925"
FT DOMAIN 65..111
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ SEQUENCE 555 AA; 62630 MW; 457ABB301C592E32 CRC64;
MLLFLSVPQP RPPGARTRAG AARVARWRRL RLQQLRRLRG LLRVLRGRPG AGSRRRGRMA
LCGQAAGAAS LPSELIVHIF SFLPAPDRLR ASASCSHWRE CLFYPALWPQ LRICLRVSPA
EQPRLEFLMR KCGWFVRELR VEFAAENYLS GGGPGDGGGA DTGTGGEEVE ALQLSARWLE
VLRTYLELVL CVLVSIRNNR NLQKFSLFGD ISVLQQQGSL SNTYLSKVDP DGKKIKQIQQ
LFEEILSNSR QLKWLSCGFM LEIVTPTSLS SLSNAVANTM EHLSLLDNNI PGNSTLITAV
ELERFVNLHS LALDFCDFTA EMARVLTDSN HVPLQRLSLL VHNVSVMHKS LDNMPNDEHW
KALSRKSTSF RVYIMAFDIK SEDMLKILKP SIPLERIHFD SYITCVSGAI VDLISRQYDK
FLTHFILMND VIDTSGFPDL SDNRNEDPLV LLAWRCTKLS LLAIHGYTVW AHNLIAIARL
RGSDLKVLEV TEESIDFDQG ELADQDVDPV HNLIEQVSLG LGQPWHAVMD IESLSVFTEP
NRHFYREMQS FSEDI
