FBX33_MOUSE
ID FBX33_MOUSE Reviewed; 562 AA.
AC Q8VE08; A0JLR4; E9QMJ3;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=F-box only protein 33;
DE AltName: Full=AIG30-12-1;
GN Name=Fbxo33;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 10-562.
RC STRAIN=Czech II, and FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP INTERACTION WITH YBX1, IDENTIFICATION IN THE SCF(FBXO33) COMPLEX WITH CUL1;
RP SKP1 AND RBX1, AND FUNCTION IN UBIQUITINATION OF YBX1.
RX PubMed=16797541; DOI=10.1016/j.febslet.2006.06.023;
RA Lutz M., Wempe F., Bahr I., Zopf D., von Melchner H.;
RT "Proteasomal degradation of the multifunctional regulator YB-1 is mediated
RT by an F-Box protein induced during programmed cell death.";
RL FEBS Lett. 580:3921-3930(2006).
CC -!- FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box
CC protein) E3 ubiquitin-protein ligase complex which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. Probably recognizes and binds to phosphorylated target
CC proteins. Recognizes YBX1. {ECO:0000269|PubMed:16797541}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SUBUNIT: Part of the SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase
CC complex SCF(FBXO33) formed of CUL1, SKP1, RBX1 and FBXO33. Interacts
CC via its N-terminus with YBX1 CSD domain. Directly interacts with SKP1
CC and CUL1 (By similarity). {ECO:0000250}.
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DR EMBL; AC147101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006669; AAH06669.1; -; mRNA.
DR EMBL; BC020022; AAH20022.1; -; mRNA.
DR CCDS; CCDS49072.1; -.
DR RefSeq; NP_001028328.2; NM_001033156.4.
DR AlphaFoldDB; Q8VE08; -.
DR BioGRID; 214164; 2.
DR STRING; 10090.ENSMUSP00000035948; -.
DR PhosphoSitePlus; Q8VE08; -.
DR EPD; Q8VE08; -.
DR PaxDb; Q8VE08; -.
DR PRIDE; Q8VE08; -.
DR ProteomicsDB; 271674; -.
DR Antibodypedia; 23412; 79 antibodies from 17 providers.
DR DNASU; 70611; -.
DR Ensembl; ENSMUST00000043204; ENSMUSP00000035948; ENSMUSG00000035329.
DR GeneID; 70611; -.
DR KEGG; mmu:70611; -.
DR UCSC; uc007nqj.2; mouse.
DR CTD; 254170; -.
DR MGI; MGI:1917861; Fbxo33.
DR VEuPathDB; HostDB:ENSMUSG00000035329; -.
DR eggNOG; ENOG502QPU4; Eukaryota.
DR GeneTree; ENSGT00390000017718; -.
DR HOGENOM; CLU_042932_0_0_1; -.
DR InParanoid; Q8VE08; -.
DR OMA; YPALWTE; -.
DR OrthoDB; 451668at2759; -.
DR PhylomeDB; Q8VE08; -.
DR TreeFam; TF321665; -.
DR UniPathway; UPA00143; -.
DR BioGRID-ORCS; 70611; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Fbxo33; mouse.
DR PRO; PR:Q8VE08; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q8VE08; protein.
DR Bgee; ENSMUSG00000035329; Expressed in choroid plexus epithelium and 244 other tissues.
DR ExpressionAtlas; Q8VE08; baseline and differential.
DR Genevisible; Q8VE08; MM.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:InterPro.
DR GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039940; FBXO33.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR20933; PTHR20933; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..562
FT /note="F-box only protein 33"
FT /id="PRO_0000314464"
FT DOMAIN 68..114
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 155..176
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 514
FT /note="V -> A (in Ref. 2; AC147101)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 562 AA; 63363 MW; D7D423279B015872 CRC64;
MLLFLSVPQP RPPGARTRAG AARLVRWRRR QRLRLLQLRR LRGLLRGLRR RPGTGGRRPS
RMALCGQAAG AASLPSELIV HIFSFLPAPD RLRASASCSH WRECLFYPAL WPQLRICLRV
SPAEQPRLEF LMRKCGWFVR ELRVEFAAEN YLSGGGGPGD GGSGGGTDTG TGGEDGEALQ
LSSRWLEVLR IYLELVLCVL LSIRNNRNLQ KFSLFGDISV VHQQGSLSST YLSRVDPDGK
KIKQIQQLFE EILSNSRQLK WLSCGFMLEI VTPTSLSSLS NPIANTMEHL SLLDNNIPGN
STLITAVELE RFVNLRSLAL DFCDFTAEMA RVLTDSNHVP LQRLSLLVHN ASVMLKSLDN
MPNDEHWKAL SRKSSSLRVY LMVFDIKSED MLKILKPSIP LERVHFDSYV TCVSGAIVDL
ISRQYDKFLT HFILMNDMID TSGFPDLSDN RNEDPLVLLA WRCTKLTLLA IHGYTVWAHN
LIAIARLRGS DLKVLQVTEE SIDFDQGELA DQDVDPVQNL IEQVSLGLGQ SWHAVLDIES
LSVFTEPNRH FYREMQSFSE DI
