FBX34_HUMAN
ID FBX34_HUMAN Reviewed; 711 AA.
AC Q9NWN3; Q2VPB5; Q4VBP5; Q86TY4;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=F-box only protein 34;
GN Name=FBXO34; Synonyms=FBX34;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Neuroblastoma;
RA Li W.B., Gruber C., Jessee J., Polayes D.;
RT "Full-length cDNA libraries and normalization.";
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASN-470 AND PRO-533.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 405-711, AND VARIANTS ASN-470 AND
RP PRO-533.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 407-711, AND VARIANTS ASN-470 AND
RP PRO-533.
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9NWN3; P05187: ALPP; NbExp=3; IntAct=EBI-719816, EBI-1211484;
CC Q9NWN3; P27658: COL8A1; NbExp=3; IntAct=EBI-719816, EBI-747133;
CC Q9NWN3; Q9NRI5-2: DISC1; NbExp=3; IntAct=EBI-719816, EBI-11988027;
CC Q9NWN3; Q92915-2: FGF14; NbExp=3; IntAct=EBI-719816, EBI-12836320;
CC Q9NWN3; Q6A162: KRT40; NbExp=3; IntAct=EBI-719816, EBI-10171697;
CC Q9NWN3; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-719816, EBI-10217483;
CC Q9NWN3; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-719816, EBI-10172150;
CC Q9NWN3; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-719816, EBI-10171774;
CC Q9NWN3; P60329: KRTAP12-4; NbExp=4; IntAct=EBI-719816, EBI-10176396;
CC Q9NWN3; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-719816, EBI-10302392;
CC Q9NWN3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-719816, EBI-739863;
CC Q9NWN3; Q9BYR2: KRTAP4-5; NbExp=5; IntAct=EBI-719816, EBI-11993254;
CC Q9NWN3; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-719816, EBI-11974251;
CC Q9NWN3; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-719816, EBI-1044640;
CC Q9NWN3; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-719816, EBI-1043191;
CC Q9NWN3; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-719816, EBI-11958364;
CC Q9NWN3; Q99750: MDFI; NbExp=3; IntAct=EBI-719816, EBI-724076;
CC Q9NWN3; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-719816, EBI-742948;
CC Q9NWN3; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-719816, EBI-11522433;
CC Q9NWN3; Q8WWZ8: OIT3; NbExp=3; IntAct=EBI-719816, EBI-10277776;
CC Q9NWN3; B2RUY7: VWC2L; NbExp=3; IntAct=EBI-719816, EBI-11747707;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91346.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAD62596.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX248268; CAD62596.1; ALT_INIT; mRNA.
DR EMBL; BC095482; AAH95482.2; -; mRNA.
DR EMBL; BC109120; AAI09121.1; -; mRNA.
DR EMBL; BC109121; AAI09122.1; -; mRNA.
DR EMBL; AK000732; BAA91346.1; ALT_INIT; mRNA.
DR EMBL; CR457249; CAG33530.1; -; mRNA.
DR CCDS; CCDS32086.1; -.
DR RefSeq; NP_060413.2; NM_017943.3.
DR RefSeq; NP_689417.1; NM_152231.1.
DR RefSeq; XP_005267848.1; XM_005267791.4.
DR RefSeq; XP_006720248.1; XM_006720185.3.
DR RefSeq; XP_016876881.1; XM_017021392.1.
DR RefSeq; XP_016876882.1; XM_017021393.1.
DR AlphaFoldDB; Q9NWN3; -.
DR BioGRID; 120359; 45.
DR IntAct; Q9NWN3; 32.
DR STRING; 9606.ENSP00000313159; -.
DR iPTMnet; Q9NWN3; -.
DR PhosphoSitePlus; Q9NWN3; -.
DR BioMuta; FBXO34; -.
DR DMDM; 61252689; -.
DR MassIVE; Q9NWN3; -.
DR PaxDb; Q9NWN3; -.
DR PeptideAtlas; Q9NWN3; -.
DR PRIDE; Q9NWN3; -.
DR ProteomicsDB; 82956; -.
DR Antibodypedia; 24028; 105 antibodies from 18 providers.
DR DNASU; 55030; -.
DR Ensembl; ENST00000313833.5; ENSP00000313159.4; ENSG00000178974.11.
DR Ensembl; ENST00000440021.1; ENSP00000394117.1; ENSG00000178974.11.
DR Ensembl; ENST00000679934.1; ENSP00000505918.1; ENSG00000178974.11.
DR Ensembl; ENST00000680658.1; ENSP00000506499.1; ENSG00000178974.11.
DR Ensembl; ENST00000680682.1; ENSP00000504946.1; ENSG00000178974.11.
DR Ensembl; ENST00000681074.1; ENSP00000506304.1; ENSG00000178974.11.
DR Ensembl; ENST00000681400.1; ENSP00000506349.1; ENSG00000178974.11.
DR Ensembl; ENST00000681904.1; ENSP00000505815.1; ENSG00000178974.11.
DR GeneID; 55030; -.
DR KEGG; hsa:55030; -.
DR MANE-Select; ENST00000313833.5; ENSP00000313159.4; NM_017943.4; NP_060413.2.
DR UCSC; uc001xbu.4; human.
DR CTD; 55030; -.
DR DisGeNET; 55030; -.
DR GeneCards; FBXO34; -.
DR HGNC; HGNC:20201; FBXO34.
DR HPA; ENSG00000178974; Low tissue specificity.
DR MIM; 609104; gene.
DR neXtProt; NX_Q9NWN3; -.
DR OpenTargets; ENSG00000178974; -.
DR PharmGKB; PA134910884; -.
DR VEuPathDB; HostDB:ENSG00000178974; -.
DR eggNOG; ENOG502QRQQ; Eukaryota.
DR GeneTree; ENSGT00530000064222; -.
DR InParanoid; Q9NWN3; -.
DR OMA; IYPNTMC; -.
DR OrthoDB; 329015at2759; -.
DR PhylomeDB; Q9NWN3; -.
DR TreeFam; TF331673; -.
DR PathwayCommons; Q9NWN3; -.
DR SignaLink; Q9NWN3; -.
DR BioGRID-ORCS; 55030; 10 hits in 1120 CRISPR screens.
DR ChiTaRS; FBXO34; human.
DR GenomeRNAi; 55030; -.
DR Pharos; Q9NWN3; Tdark.
DR PRO; PR:Q9NWN3; -.
DR Proteomes; UP000005640; Chromosome 14.
DR RNAct; Q9NWN3; protein.
DR Bgee; ENSG00000178974; Expressed in secondary oocyte and 210 other tissues.
DR ExpressionAtlas; Q9NWN3; baseline and differential.
DR Genevisible; Q9NWN3; HS.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039594; FBXO34/46.
DR PANTHER; PTHR16271; PTHR16271; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..711
FT /note="F-box only protein 34"
FT /id="PRO_0000119926"
FT DOMAIN 572..624
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 249..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 494..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 432
FT /note="V -> A (in dbSNP:rs35070799)"
FT /id="VAR_049047"
FT VARIANT 470
FT /note="I -> N (in dbSNP:rs1045002)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_021489"
FT VARIANT 533
FT /note="L -> P (in dbSNP:rs3742569)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.4"
FT /id="VAR_021490"
FT VARIANT 704
FT /note="G -> V (in dbSNP:rs10138395)"
FT /id="VAR_049048"
SQ SEQUENCE 711 AA; 78711 MW; 6D289A9320AE9C42 CRC64;
MHLKPYWKLQ KKEHPPEVSR ETQRTPMNHQ KAVNDETCKA SHITSSVFPS ASLGKASSRK
PFGILSPNVL CSMSGKSPVE SSLNVKTKKN APSATIHQGE EEGPLDIWAV VKPGNTKEKI
AFFASHQCSN RIGSMKIKSS WDIDGRATKR RKKSGDLKKA KVQVERMREV NSRCYQPEPF
ACGIEHCSVH YVSDSGDGVY AGRPLSVIQM VAFLEQRASA LLASCSKNCT NSPAIVRFSG
QSRGVPAVSE SYSAPGACEE PTERGNLEVG EPQSEPVRVL DMVAKLESEC LKRQGQREPG
SLSRNNSFRR NVGRVLLANS TQADEGKTKK GVLEAPDTQV NPVGSVSVDC GPSRADRCSP
KEDQAWDGAS QDCPPLPAGV SFHIDSAELE PGSQTAVKNS NRYDVEMTDE LVGLPFSSHT
YSQASELPTD AVDCMSRELV SLTSRNPDQR KESLCISITV SKVDKDQPSI LNSCEDPVPG
MLFFLPPGQH LSDYSQLNES TTKESSEASQ LEDAAGGDSA SEEKSGSAEP FVLPASSVES
TLPVLEASSW KKQVSHDFLE TRFKIQQLLE PQQYMAFLPH HIMVKIFRLL PTKSLVALKC
TCCYFKFIIE YYNIRPADSR WVRDPRYRED PCKQCKKKYV KGDVSLCRWH PKPYCQALPY
GPGYWMCCHR SQKGFPGCKL GLHDNHWVPA CHSFNRAIHK KAKGTEAEEE Y
