FBX34_MOUSE
ID FBX34_MOUSE Reviewed; 695 AA.
AC Q80XI1; Q9D290;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=F-box only protein 34;
GN Name=Fbxo34;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q80XI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q80XI1-2; Sequence=VSP_013055;
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DR EMBL; AK020018; BAB31968.1; -; mRNA.
DR EMBL; BC048149; AAH48149.1; -; mRNA.
DR CCDS; CCDS49471.1; -. [Q80XI1-1]
DR RefSeq; NP_001139557.1; NM_001146085.1. [Q80XI1-1]
DR RefSeq; NP_001139558.1; NM_001146086.1. [Q80XI1-1]
DR RefSeq; NP_084512.2; NM_030236.3.
DR RefSeq; XP_006519776.1; XM_006519713.1. [Q80XI1-1]
DR RefSeq; XP_006519777.1; XM_006519714.1. [Q80XI1-1]
DR RefSeq; XP_006519780.1; XM_006519717.2. [Q80XI1-1]
DR RefSeq; XP_006519781.1; XM_006519718.3. [Q80XI1-1]
DR RefSeq; XP_006519782.1; XM_006519719.1. [Q80XI1-1]
DR RefSeq; XP_006519783.1; XM_006519720.1. [Q80XI1-1]
DR RefSeq; XP_006519785.1; XM_006519722.1. [Q80XI1-1]
DR RefSeq; XP_006519786.1; XM_006519723.3.
DR RefSeq; XP_017171714.1; XM_017316225.1. [Q80XI1-1]
DR RefSeq; XP_017171715.1; XM_017316226.1. [Q80XI1-1]
DR AlphaFoldDB; Q80XI1; -.
DR BioGRID; 219722; 4.
DR STRING; 10090.ENSMUSP00000044675; -.
DR iPTMnet; Q80XI1; -.
DR PhosphoSitePlus; Q80XI1; -.
DR EPD; Q80XI1; -.
DR jPOST; Q80XI1; -.
DR PaxDb; Q80XI1; -.
DR PRIDE; Q80XI1; -.
DR ProteomicsDB; 272966; -. [Q80XI1-1]
DR ProteomicsDB; 272967; -. [Q80XI1-2]
DR Antibodypedia; 24028; 105 antibodies from 18 providers.
DR Ensembl; ENSMUST00000095941; ENSMUSP00000093634; ENSMUSG00000037536. [Q80XI1-1]
DR Ensembl; ENSMUST00000163324; ENSMUSP00000131708; ENSMUSG00000037536. [Q80XI1-1]
DR Ensembl; ENSMUST00000165714; ENSMUSP00000130036; ENSMUSG00000037536. [Q80XI1-1]
DR Ensembl; ENSMUST00000168833; ENSMUSP00000132271; ENSMUSG00000037536. [Q80XI1-1]
DR GeneID; 78938; -.
DR KEGG; mmu:78938; -.
DR UCSC; uc007tih.2; mouse. [Q80XI1-1]
DR CTD; 55030; -.
DR MGI; MGI:1926188; Fbxo34.
DR VEuPathDB; HostDB:ENSMUSG00000037536; -.
DR eggNOG; ENOG502QRQQ; Eukaryota.
DR GeneTree; ENSGT00530000064222; -.
DR HOGENOM; CLU_418530_0_0_1; -.
DR InParanoid; Q80XI1; -.
DR OMA; IYPNTMC; -.
DR OrthoDB; 329015at2759; -.
DR PhylomeDB; Q80XI1; -.
DR BioGRID-ORCS; 78938; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Fbxo34; mouse.
DR PRO; PR:Q80XI1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q80XI1; protein.
DR Bgee; ENSMUSG00000037536; Expressed in animal zygote and 218 other tissues.
DR ExpressionAtlas; Q80XI1; baseline and differential.
DR Genevisible; Q80XI1; MM.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039594; FBXO34/46.
DR PANTHER; PTHR16271; PTHR16271; 1.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..695
FT /note="F-box only protein 34"
FT /id="PRO_0000119927"
FT DOMAIN 556..608
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 239..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 472..524
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..346
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1
FT /note="M -> MGFGASVGLRRSALSSWSASVSGSESGLPPPHRAAAAPGQALARQKH
FT RASV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013055"
FT CONFLICT 165
FT /note="M -> I (in Ref. 2; AAH48149)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="K -> E (in Ref. 1; BAB31968)"
FT /evidence="ECO:0000305"
FT CONFLICT 491
FT /note="E -> K (in Ref. 1; BAB31968)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 695 AA; 77138 MW; D97EFBB6588E5FCC CRC64;
MHLKLYWKLQ KKERPLEVSR DTLRTPMSHG KANGDVKARA SYMKPTVLPS ASLVKASSRK
PFGILSPNVL CSMSGKSPVE NSLNVKAKKN VLSAAVHQSE EGLPGTWAIV KPGNTKEKIA
FFAAHQYSNR IGSMKIKSSW DIDGRATKRR KKSGDLKKAK LQLEMMREIN SQCYQSEPFV
CGVEHCSVHY MSDSGDGVCA ARPLSVIQMV AFLEQKATAL LASCTKNCTN SPAIVKISGQ
SRGIPPAPEP FSAPETCEEP KEQENPETGR SQGEPVRVLD MVARLESECL KHQGQREPGS
LSRNNSFRRN VGRVLLTNGS QASDKSEEGS ADTADPQENP LQPVSVGEEP SVTEHHSVGE
QAWDGTSQSC PSLPATVSFH MDSTDLEPGQ QTAMKSCSRD DVEMVEEFDE LPTDAVRRIR
RELVTVTKHS PEQRQDPLCI SITVCTVEKD RPAALDSLEE PLPGMLFFLS SGQDQQAHPQ
LREHPAPEAS EASQPQDAAE GSSAGEEKDA SVEPLLPAAS PGGSTSQVLE AATCKKQVSQ
DFLETRFKIQ QLLEPQQYMA CLPHHIIVKI FRLLPTLSLA ILKCTCRYFK SIIEYYNIRP
ADSRWVRDPR YREDPCKQCK KKYVKGDVSL CRWHPKPYCQ ALPYGPGYWM CCHQSQKGFP
GCKLGLHDNH WLPACHSFNR AIHKKTRGSE TEEEY
