FBX36_HUMAN
ID FBX36_HUMAN Reviewed; 188 AA.
AC Q8NEA4; B3KVQ6; Q53TE6; Q8WWD4;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=F-box only protein 36;
GN Name=FBXO36; Synonyms=FBX36;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PHE-86.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NEA4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NEA4-3; Sequence=VSP_054336;
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DR EMBL; AK123085; BAG53868.1; -; mRNA.
DR EMBL; AK289655; BAF82344.1; -; mRNA.
DR EMBL; AC009973; AAY14756.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70909.1; -; Genomic_DNA.
DR EMBL; CH471063; EAW70912.1; -; Genomic_DNA.
DR EMBL; BC033935; AAH33935.1; -; mRNA.
DR CCDS; CCDS2472.1; -. [Q8NEA4-1]
DR RefSeq; NP_777559.3; NM_174899.4. [Q8NEA4-1]
DR AlphaFoldDB; Q8NEA4; -.
DR SMR; Q8NEA4; -.
DR BioGRID; 126262; 2.
DR STRING; 9606.ENSP00000283946; -.
DR PhosphoSitePlus; Q8NEA4; -.
DR BioMuta; FBXO36; -.
DR DMDM; 212288605; -.
DR EPD; Q8NEA4; -.
DR MassIVE; Q8NEA4; -.
DR PaxDb; Q8NEA4; -.
DR PeptideAtlas; Q8NEA4; -.
DR PRIDE; Q8NEA4; -.
DR ProteomicsDB; 3763; -.
DR ProteomicsDB; 73138; -. [Q8NEA4-1]
DR Antibodypedia; 34398; 114 antibodies from 21 providers.
DR DNASU; 130888; -.
DR Ensembl; ENST00000283946.8; ENSP00000283946.3; ENSG00000153832.12. [Q8NEA4-1]
DR Ensembl; ENST00000373652.7; ENSP00000362756.3; ENSG00000153832.12. [Q8NEA4-3]
DR GeneID; 130888; -.
DR KEGG; hsa:130888; -.
DR MANE-Select; ENST00000283946.8; ENSP00000283946.3; NM_174899.5; NP_777559.3.
DR UCSC; uc002vqa.4; human. [Q8NEA4-1]
DR CTD; 130888; -.
DR GeneCards; FBXO36; -.
DR HGNC; HGNC:27020; FBXO36.
DR HPA; ENSG00000153832; Low tissue specificity.
DR MIM; 609105; gene.
DR neXtProt; NX_Q8NEA4; -.
DR OpenTargets; ENSG00000153832; -.
DR PharmGKB; PA134918778; -.
DR VEuPathDB; HostDB:ENSG00000153832; -.
DR eggNOG; KOG1777; Eukaryota.
DR GeneTree; ENSGT00390000001015; -.
DR InParanoid; Q8NEA4; -.
DR OMA; RFAKLCT; -.
DR OrthoDB; 1245866at2759; -.
DR PhylomeDB; Q8NEA4; -.
DR TreeFam; TF329337; -.
DR PathwayCommons; Q8NEA4; -.
DR BioGRID-ORCS; 130888; 12 hits in 1107 CRISPR screens.
DR ChiTaRS; FBXO36; human.
DR GenomeRNAi; 130888; -.
DR Pharos; Q8NEA4; Tdark.
DR PRO; PR:Q8NEA4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8NEA4; protein.
DR Bgee; ENSG00000153832; Expressed in sperm and 104 other tissues.
DR ExpressionAtlas; Q8NEA4; baseline and differential.
DR Genevisible; Q8NEA4; HS.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR Pfam; PF00646; F-box; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..188
FT /note="F-box only protein 36"
FT /id="PRO_0000119928"
FT DOMAIN 91..137
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT VAR_SEQ 1..32
FT /note="MASWLPETLFETVGQGPPPSKDYYQLLVTRSQ -> M (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054336"
FT VARIANT 86
FT /note="L -> F (in dbSNP:rs1035834)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_045626"
SQ SEQUENCE 188 AA; 22105 MW; 3DBC55B437EB2A39 CRC64;
MASWLPETLF ETVGQGPPPS KDYYQLLVTR SQVIFRWWKI SLRSEYRSTK PGEAKETHED
FLENSHLQGQ TALIFGARIL DYVINLCKGK FDFLERLSDD LLLTIISYLD LEDIARLCQT
SHRFAKLCMS DKLWEQIVQS TCDTITPDVR ALAEDTGWRQ LFFTNKLQLQ RQLRKRKQKY
GNLREKQP
