FBX39_MOUSE
ID FBX39_MOUSE Reviewed; 443 AA.
AC Q5NBU5;
DT 15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=F-box only protein 39;
GN Name=Fbxo39;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR EMBL; AL929071; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS36214.1; -.
DR RefSeq; NP_001093158.1; NM_001099688.2.
DR RefSeq; XP_006533965.2; XM_006533902.3.
DR AlphaFoldDB; Q5NBU5; -.
DR STRING; 10090.ENSMUSP00000104144; -.
DR iPTMnet; Q5NBU5; -.
DR PhosphoSitePlus; Q5NBU5; -.
DR PaxDb; Q5NBU5; -.
DR PRIDE; Q5NBU5; -.
DR ProteomicsDB; 271884; -.
DR Antibodypedia; 53192; 97 antibodies from 15 providers.
DR Ensembl; ENSMUST00000108504; ENSMUSP00000104144; ENSMUSG00000070388.
DR GeneID; 628100; -.
DR KEGG; mmu:628100; -.
DR UCSC; uc007jys.2; mouse.
DR CTD; 162517; -.
DR MGI; MGI:3505735; Fbxo39.
DR VEuPathDB; HostDB:ENSMUSG00000070388; -.
DR eggNOG; KOG1947; Eukaryota.
DR GeneTree; ENSGT00510000048837; -.
DR HOGENOM; CLU_050223_0_0_1; -.
DR InParanoid; Q5NBU5; -.
DR OMA; KCILTTI; -.
DR OrthoDB; 1046098at2759; -.
DR PhylomeDB; Q5NBU5; -.
DR TreeFam; TF321665; -.
DR BioGRID-ORCS; 628100; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q5NBU5; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q5NBU5; protein.
DR Bgee; ENSMUSG00000070388; Expressed in testis and 3 other tissues.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR045048; FBXO31/39.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR10706; PTHR10706; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..443
FT /note="F-box only protein 39"
FT /id="PRO_0000119936"
FT DOMAIN 13..59
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ SEQUENCE 443 AA; 52554 MW; 4F7D3B5F8B579213 CRC64;
MDEDCEVTQL QEQSCWATLP DVCLRRVFWW LGDRDRSRAA LVCRKWNQIM YSADLWRYRT
ITFSGRPSRV HASEFESALW YIKKFGRYLE HLEIKFLNPY NAVLTKKFQV TMRGLLSCLG
KSNNRLRSLS IQHLELDRLV WRNSIRGSLI KSLSFFLKKM GKHLDHLSLK GARLTVEQGC
HILNSLSYMQ NENMASELNI EDFFSHHLAV YGSSQFNKAM ATFRNLTFLT LNYNCISDEL
LETLSENNAG TLRTMNIKCH VHDPHGQVVW GMSWAKLARQ ASNLKVNFFF ERVMKYERLA
RILLQEIPVR SISLRSCYFS DPDWSMRPTL TDLLPTFRNT LQKLTFEFNN NHESLDEQLH
LLILACRKLF YFKIWAFLDV KFVERILKSQ EEGQCSLHTL KVRIYTNRYE TNEEDRTLRE
IYRKYRKLID SELNYFVVAY PMM