ID   FBX39_RAT               Reviewed;         443 AA.
AC   Q66H10; Q498T6;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=F-box only protein 39;
GN   Name=Fbxo39;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH82089.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; BC082089; AAH82089.1; ALT_SEQ; mRNA.
DR   EMBL; BC100079; AAI00080.1; -; mRNA.
DR   RefSeq; NP_001034107.1; NM_001039018.1.
DR   RefSeq; XP_006246789.1; XM_006246727.3.
DR   RefSeq; XP_006246791.1; XM_006246729.3.
DR   AlphaFoldDB; Q66H10; -.
DR   SMR; Q66H10; -.
DR   STRING; 10116.ENSRNOP00000020071; -.
DR   PaxDb; Q66H10; -.
DR   PRIDE; Q66H10; -.
DR   Ensembl; ENSRNOT00000020071; ENSRNOP00000020071; ENSRNOG00000014953.
DR   GeneID; 303287; -.
DR   KEGG; rno:303287; -.
DR   CTD; 162517; -.
DR   RGD; 1311464; Fbxo39.
DR   eggNOG; KOG1947; Eukaryota.
DR   GeneTree; ENSGT00510000048837; -.
DR   HOGENOM; CLU_050223_0_0_1; -.
DR   InParanoid; Q66H10; -.
DR   OMA; KCILTTI; -.
DR   OrthoDB; 1046098at2759; -.
DR   PhylomeDB; Q66H10; -.
DR   TreeFam; TF321665; -.
DR   PRO; PR:Q66H10; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000014953; Expressed in testis and 11 other tissues.
DR   Genevisible; Q66H10; RN.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR045048; FBXO31/39.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR10706; PTHR10706; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..443
FT                   /note="F-box only protein 39"
FT                   /id="PRO_0000119937"
FT   DOMAIN          13..59
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ   SEQUENCE   443 AA;  52504 MW;  0A164BAC55B4B97F CRC64;
     MDEDSEVTQP QDQSCWATLP DVCLRRVFWW LGDRDRSRAA LVCRKWNQIM YSADLWRYRT
     ITFSGRPSRV HASEFESALW YVKKFGRYLE HLEIKFLNPY NAVLTKKFQV TMRGLLSCLG
     KSNNRLRSLS IQHLELDRLV WRNSIRGSLI KSLSFFLKKM GKHLDHLSLK GARLTVEQGC
     HILNSLSYMR NENVASELNI EDFFSHHLAV YGSSQFNKAM ATFHNLTFLT LNYNCISDEL
     LETLSENNAG TLRTMNIKCH VHDPHGQVVW GMSWAKLARQ ASNLKVNFFF ERVMKYERLA
     RILLQEIPVR SISLRSCYFS DPDWSMRPTL TDLLPTFRNT LQKLTFEFNN NHESLDEQLH
     LLILACRKLF YFKIWAFLDV KFVERILKSQ EEGQCSLRTL KVRIYTNRYE TNEEDRTLRE
     IYRKYRKLID SELNYFVIAY PMM