ID   FBX3_BOVIN              Reviewed;         469 AA.
AC   A6H7H7;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=F-box only protein 3;
GN   Name=FBXO3; Synonyms=FBX3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination
CC       of HIPK2 and probably that of EP300, leading to rapid degradation by
CC       the proteasome. In the presence of PML, HIPK2 ubiquitination still
CC       occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act
CC       synergically to activate p53/TP53-dependent transactivation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex
CC       consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML,
CC       either alone or within the SCF complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with PML
CC       at the peripheries of nuclear bodies. {ECO:0000250}.
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DR   EMBL; BC146250; AAI46251.1; -; mRNA.
DR   RefSeq; NP_001092532.1; NM_001099062.1.
DR   AlphaFoldDB; A6H7H7; -.
DR   SMR; A6H7H7; -.
DR   STRING; 9913.ENSBTAP00000013287; -.
DR   PaxDb; A6H7H7; -.
DR   PRIDE; A6H7H7; -.
DR   Ensembl; ENSBTAT00000013287; ENSBTAP00000013287; ENSBTAG00000010071.
DR   GeneID; 534287; -.
DR   KEGG; bta:534287; -.
DR   CTD; 26273; -.
DR   VEuPathDB; HostDB:ENSBTAG00000010071; -.
DR   VGNC; VGNC:28902; FBXO3.
DR   eggNOG; KOG4408; Eukaryota.
DR   GeneTree; ENSGT00940000153571; -.
DR   HOGENOM; CLU_056869_0_0_1; -.
DR   InParanoid; A6H7H7; -.
DR   OMA; YRDLVSC; -.
DR   OrthoDB; 506060at2759; -.
DR   TreeFam; TF329795; -.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000010071; Expressed in semen and 105 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   Gene3D; 2.60.40.1470; -; 1.
DR   Gene3D; 3.40.1580.10; -; 1.
DR   InterPro; IPR007474; ApaG_domain.
DR   InterPro; IPR036767; ApaG_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR028388; FBXO3.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   PANTHER; PTHR46550:SF3; PTHR46550:SF3; 1.
DR   Pfam; PF04379; DUF525; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF09346; SMI1_KNR4; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00860; SMI1_KNR4; 1.
DR   SUPFAM; SSF110069; SSF110069; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS51087; APAG; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..469
FT                   /note="F-box only protein 3"
FT                   /id="PRO_0000396823"
FT   DOMAIN          10..56
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          278..408
FT                   /note="ApaG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00412"
FT   REGION          419..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..447
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  54129 MW;  E6F4B59651585F1F CRC64;
     MAAMDTESAP LTLESLPTDP LLLILSFLDY RDLINCCYVS RRLSQLSSHD PLWRRHCKKY
     WLISEEEKTQ KNQCWKSLFI DTYSDVGRYI DHYAAIKKAW DDLKKYLEPR CPRMVLSLKE
     GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA
     AGGFQQRQGL KSCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI
     IGATFTDWFT SYVNSVVSGG FPIIRDQIFR YVHDPECVAT TGDITVSVST SFLPELSSVH
     PPHYFFTYRI RIEMSKDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRV
     YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK IFNVAIPRFH MACPTFRVSI ARLEMGPDEY
     EEMEEEEEEE EEEDDDDSAD MDESDDDEEE RQRRVFDVPI RRRRCSRLF