ID   FBX3_RAT                Reviewed;         480 AA.
AC   D4ABP9;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=F-box only protein 3;
GN   Name=Fbxo3; Synonyms=Fbx3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination
CC       of HIPK2, and probably that of EP300, leading to rapid degradation by
CC       the proteasome. In the presence of PML, HIPK2 ubiquitination still
CC       occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act
CC       synergically to activate p53/TP53-dependent transactivation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex
CC       consisting of FBXO3, SKP1, CUL1 and RBX1. Directly interacts with PML,
CC       either alone or within the SCF complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with PML
CC       at the peripheries of nuclear bodies. {ECO:0000250}.
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DR   EMBL; CH473949; EDL79684.1; -; Genomic_DNA.
DR   RefSeq; NP_001103076.1; NM_001109606.1.
DR   AlphaFoldDB; D4ABP9; -.
DR   SMR; D4ABP9; -.
DR   STRING; 10116.ENSRNOP00000014478; -.
DR   jPOST; D4ABP9; -.
DR   PaxDb; D4ABP9; -.
DR   PeptideAtlas; D4ABP9; -.
DR   Ensembl; ENSRNOT00000014478; ENSRNOP00000014478; ENSRNOG00000009549.
DR   GeneID; 690634; -.
DR   KEGG; rno:690634; -.
DR   UCSC; RGD:1593433; rat.
DR   CTD; 26273; -.
DR   RGD; 1593433; Fbxo3.
DR   eggNOG; KOG4408; Eukaryota.
DR   GeneTree; ENSGT00940000153571; -.
DR   HOGENOM; CLU_056869_0_0_1; -.
DR   InParanoid; D4ABP9; -.
DR   OMA; YRDLVSC; -.
DR   OrthoDB; 506060at2759; -.
DR   PhylomeDB; D4ABP9; -.
DR   TreeFam; TF329795; -.
DR   PRO; PR:D4ABP9; -.
DR   Proteomes; UP000002494; Chromosome 3.
DR   Proteomes; UP000234681; Chromosome 3.
DR   Bgee; ENSRNOG00000009549; Expressed in liver and 20 other tissues.
DR   Genevisible; D4ABP9; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   Gene3D; 2.60.40.1470; -; 1.
DR   Gene3D; 3.40.1580.10; -; 1.
DR   InterPro; IPR007474; ApaG_domain.
DR   InterPro; IPR036767; ApaG_sf.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR028388; FBXO3.
DR   InterPro; IPR018958; Knr4/Smi1-like_dom.
DR   InterPro; IPR037883; Knr4/Smi1-like_sf.
DR   PANTHER; PTHR46550:SF3; PTHR46550:SF3; 1.
DR   Pfam; PF04379; DUF525; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   Pfam; PF09346; SMI1_KNR4; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SMART; SM00860; SMI1_KNR4; 1.
DR   SUPFAM; SSF110069; SSF110069; 1.
DR   SUPFAM; SSF160631; SSF160631; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS51087; APAG; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..480
FT                   /note="F-box only protein 3"
FT                   /id="PRO_0000396824"
FT   DOMAIN          10..56
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   DOMAIN          278..408
FT                   /note="ApaG"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00412"
FT   REGION          419..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..456
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   480 AA;  55355 MW;  99F747F05416DC90 CRC64;
     MAAVEAETGL LTLESLPTDP LLLILSFVDY RDLINCCYVS RRLSQLSTHD PLWRRHCKKY
     WLITEEEKAR KNQCWKSLFI ATYSDVGRYI NHYAAIKKAW DDLKKYLEPR CPRMVLSLKE
     GAREEDLDAV EAQIGCKLPD DYRCSYRIHN GQKLVVPGLL GSMALSNHYR SEDLLDVDTA
     AGGFQQRQGL KYCLPLTFCI HTGLSQYIAV EAAEGRNKNE VFYQCPDQMA RNPAAIDMFI
     IGATFTDWFT SYVNNVVSGG FPIIRDQIFR YIHDPECVAT TGDITVSVST SFLPELSSVH
     PPHYFFTYRI RIEMSRDALP EKACQLDSRY WRITNAKGDV EEVQGPGVVG EFPIISPGRI
     YEYTSCTTFS TTSGYMEGYY TFHFLYFKDK VFNVAIPRFH MACPTFRVSI ARLEMGPDEY
     EEMEEEAEEE EEEENDDSAD MDESDESDED ENESDEGEGE ERRRRVFDVP IRRRRCSRLF