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FBX40_MOUSE
ID   FBX40_MOUSE             Reviewed;         710 AA.
AC   P62932;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   31-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=F-box only protein 40;
GN   Name=Fbxo40;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Bone;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND SUBCELLULAR
RP   LOCATION.
RX   PubMed=17928169; DOI=10.1016/j.gene.2007.08.020;
RA   Ye J., Zhang Y., Xu J., Zhang Q., Zhu D.;
RT   "FBXO40, a gene encoding a novel muscle-specific F-box protein, is
RT   upregulated in denervation-related muscle atrophy.";
RL   Gene 404:53-60(2007).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Heart;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Probable substrate-recognition component of the SCF (SKP1-
CC       CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function
CC       in myogenesis. {ECO:0000269|PubMed:17928169}.
CC   -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17928169}.
CC   -!- TISSUE SPECIFICITY: Expressed only in heart and skeletal muscle.
CC       {ECO:0000269|PubMed:17928169}.
CC   -!- DEVELOPMENTAL STAGE: During the development of skeletal muscle, can
CC       only be detected 2 weeks after birth. {ECO:0000269|PubMed:17928169}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK036385; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK036385; -; NOT_ANNOTATED_CDS; mRNA.
DR   CCDS; CCDS37337.1; -.
DR   RefSeq; NP_001032398.1; NM_001037321.1.
DR   RefSeq; XP_006521944.1; XM_006521881.2.
DR   RefSeq; XP_006521945.1; XM_006521882.3.
DR   AlphaFoldDB; P62932; -.
DR   SMR; P62932; -.
DR   BioGRID; 228886; 4.
DR   STRING; 10090.ENSMUSP00000075266; -.
DR   iPTMnet; P62932; -.
DR   PhosphoSitePlus; P62932; -.
DR   EPD; P62932; -.
DR   PaxDb; P62932; -.
DR   PeptideAtlas; P62932; -.
DR   PRIDE; P62932; -.
DR   ProteomicsDB; 271885; -.
DR   Antibodypedia; 1237; 125 antibodies from 20 providers.
DR   Ensembl; ENSMUST00000075869; ENSMUSP00000075266; ENSMUSG00000047746.
DR   Ensembl; ENSMUST00000114806; ENSMUSP00000110454; ENSMUSG00000047746.
DR   GeneID; 207215; -.
DR   KEGG; mmu:207215; -.
DR   UCSC; uc007zdj.1; mouse.
DR   CTD; 51725; -.
DR   MGI; MGI:2443753; Fbxo40.
DR   VEuPathDB; HostDB:ENSMUSG00000047746; -.
DR   eggNOG; ENOG502QVHX; Eukaryota.
DR   GeneTree; ENSGT00950000183204; -.
DR   HOGENOM; CLU_013357_0_0_1; -.
DR   InParanoid; P62932; -.
DR   OMA; EVHISEY; -.
DR   OrthoDB; 1009974at2759; -.
DR   PhylomeDB; P62932; -.
DR   TreeFam; TF343227; -.
DR   Reactome; R-MMU-8951664; Neddylation.
DR   Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR   BioGRID-ORCS; 207215; 6 hits in 72 CRISPR screens.
DR   ChiTaRS; Fbxo40; mouse.
DR   PRO; PR:P62932; -.
DR   Proteomes; UP000000589; Chromosome 16.
DR   RNAct; P62932; protein.
DR   Bgee; ENSMUSG00000047746; Expressed in hindlimb stylopod muscle and 29 other tissues.
DR   ExpressionAtlas; P62932; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042692; P:muscle cell differentiation; IEP:UniProtKB.
DR   Gene3D; 3.30.40.10; -; 1.
DR   Gene3D; 3.30.40.150; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR031890; Fbxo30/Fbxo40.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR001293; Znf_TRAF.
DR   InterPro; IPR043013; Znf_TRAF_N.
DR   PANTHER; PTHR15933; PTHR15933; 1.
DR   Pfam; PF15966; F-box_4; 1.
DR   Pfam; PF15965; zf-TRAF_2; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
DR   PROSITE; PS50145; ZF_TRAF; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Metal-binding; Reference proteome; Ubl conjugation pathway;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..710
FT                   /note="F-box only protein 40"
FT                   /id="PRO_0000119939"
FT   DOMAIN          572..626
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   ZN_FING         53..114
FT                   /note="TRAF-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00207"
FT   REGION          152..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..279
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   710 AA;  79951 MW;  0315C62EBA9BFC45 CRC64;
     MGRARKPPPA LHRHCEGCFN RHCHVPVEPS VSCLVISCHL LCGATFHMCK ESEHTLLCPL
     EQVPCLNSEY GCPLSMARHK LAKHLQVCPA SVVCCSMEWI RWPNVDSETF LHENIMKETP
     SEECLDTALA LQDQKVLFRS LKMVELFPET RDATEEEPDM NGDTSWEETG GAVGGVDARL
     APNSCLPATS RQMMELSQEE RDALAKTKEG MDLDKFGKWE SMFSKEHAAS VLTGSLGKSE
     DKNGDVAGKE QCSSNVRIGD AEGSAERRGP QESQKSQELP ATMEMTGLAP WQDGVLERLK
     TAVDAKDYNM YLVHNGRMLI HFGQMPACTP KERDFVYGNL EAQEVKTVYT FKIPVSYCGK
     RARLGDAMLK CRPSEHKAVD TSDLGISVED LPKSDLIKTT LQCALERELK GHVISESRSI
     DGLFMDLATQ TYNFEPEQFS SETVLADLLG TAQPGGLHVE LHSECVTRRH NKSSSAFTFT
     CNKFFRRDEF PLHFKNVHTD IQSSLDGWFQ HRCPLAYLGC TFVQNHFRPP GQKAKVIYSQ
     ELKTFAIKPE VAPELSEKWK SDHLSGRDGK SLNSLTSLPL EVLQYIAGFL DSISLSQLSQ
     VSVLMRNICA TLLQERGMVL SQWKKKRYSH GGTSWKVHNQ IWQFSSLFSK INSWEFNDVT
     SMSEHLKTCP FNIVERKTDP IRLTSMCQPQ EKARESLVST FRARPRGRHF
 
 
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