FBX41_HUMAN
ID FBX41_HUMAN Reviewed; 875 AA.
AC Q8TF61; G3V0Z7; Q2M1V8;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2012, sequence version 5.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=F-box only protein 41;
GN Name=FBXO41; Synonyms=FBX41, KIAA1940;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 55-875.
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 365-875.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR EMBL; AC010913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471053; EAW99736.1; -; Genomic_DNA.
DR EMBL; AB075820; BAB85526.1; -; mRNA.
DR EMBL; BC112202; AAI12203.1; -; mRNA.
DR CCDS; CCDS46337.2; -.
DR RefSeq; NP_001073879.2; NM_001080410.2.
DR RefSeq; XP_006712013.1; XM_006711950.2.
DR RefSeq; XP_011530864.1; XM_011532562.1.
DR RefSeq; XP_016858910.1; XM_017003421.1.
DR RefSeq; XP_016858911.1; XM_017003422.1.
DR RefSeq; XP_016858912.1; XM_017003423.1.
DR AlphaFoldDB; Q8TF61; -.
DR SMR; Q8TF61; -.
DR BioGRID; 127320; 1.
DR IntAct; Q8TF61; 3.
DR STRING; 9606.ENSP00000428646; -.
DR DrugBank; DB12695; Phenethyl Isothiocyanate.
DR iPTMnet; Q8TF61; -.
DR PhosphoSitePlus; Q8TF61; -.
DR BioMuta; FBXO41; -.
DR DMDM; 387912926; -.
DR jPOST; Q8TF61; -.
DR MassIVE; Q8TF61; -.
DR PaxDb; Q8TF61; -.
DR PeptideAtlas; Q8TF61; -.
DR PRIDE; Q8TF61; -.
DR ProteomicsDB; 74561; -.
DR Antibodypedia; 65168; 58 antibodies from 19 providers.
DR DNASU; 150726; -.
DR Ensembl; ENST00000295133.9; ENSP00000295133.6; ENSG00000163013.12.
DR Ensembl; ENST00000520530.3; ENSP00000430968.2; ENSG00000163013.12.
DR Ensembl; ENST00000521871.5; ENSP00000428646.1; ENSG00000163013.12.
DR GeneID; 150726; -.
DR KEGG; hsa:150726; -.
DR MANE-Select; ENST00000520530.3; ENSP00000430968.2; NM_001371389.2; NP_001358318.1.
DR UCSC; uc021vjh.2; human.
DR CTD; 150726; -.
DR DisGeNET; 150726; -.
DR GeneCards; FBXO41; -.
DR HGNC; HGNC:29409; FBXO41.
DR HPA; ENSG00000163013; Tissue enhanced (brain).
DR MIM; 609108; gene.
DR neXtProt; NX_Q8TF61; -.
DR OpenTargets; ENSG00000163013; -.
DR PharmGKB; PA134946052; -.
DR VEuPathDB; HostDB:ENSG00000163013; -.
DR eggNOG; KOG4341; Eukaryota.
DR GeneTree; ENSGT00530000063713; -.
DR HOGENOM; CLU_018140_0_0_1; -.
DR InParanoid; Q8TF61; -.
DR OMA; HFPCREL; -.
DR OrthoDB; 236860at2759; -.
DR TreeFam; TF329439; -.
DR PathwayCommons; Q8TF61; -.
DR Reactome; R-HSA-8951664; Neddylation.
DR Reactome; R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR SignaLink; Q8TF61; -.
DR BioGRID-ORCS; 150726; 36 hits in 1119 CRISPR screens.
DR ChiTaRS; FBXO41; human.
DR GenomeRNAi; 150726; -.
DR Pharos; Q8TF61; Tbio.
DR PRO; PR:Q8TF61; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8TF61; protein.
DR Bgee; ENSG00000163013; Expressed in CA1 field of hippocampus and 164 other tissues.
DR Genevisible; Q8TF61; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Methylation; Phosphoprotein; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..875
FT /note="F-box only protein 41"
FT /id="PRO_0000119940"
FT DOMAIN 496..540
FT /note="F-box"
FT REGION 85..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 209..351
FT /evidence="ECO:0000255"
FT COMPBIAS 170..188
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..492
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 360
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT MOD_RES 478
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT MOD_RES 479
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT MOD_RES 762
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6NS60"
FT CONFLICT 454
FT /note="S -> T (in Ref. 3; BAB85526)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 875 AA; 94496 MW; B1491A923068389C CRC64;
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG AAAAAAAAAA
ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQAAGPSP AAPHLLHHHH HHAPLAHFPG
DLVPASLPCE ELAEPGLVPA AAARYALREI EIPLGELFAR KSVASSACST PPPGPGPGPC
PGPASASPAS PSPADVAYEE GLARLKIRAL EKLEVDRRLE RLSEEVEQKI AGQVGRLQAE
LERKAAELET ARQESARLGR EKEELEERAS ELSRQVDVSV ELLASLKQDL VHKEQELSRK
QQEVVQIDQF LKETAAREAS AKLRLQQFIE ELLERADRAE RQLQVISSSC GSTPSASLGR
GGGGGGAGPN ARGPGRMREH HVGPAVPNTY AVSRHGSSPS TGASSRVPAA SQSSGCYDSD
SLELPRPEEG APEDSGPGGL GTRAQAANGG SERSQPPRSS GLRRQAIQNW QRRPRRHSTE
GEEGDVSDVG SRTTESEAEG PLDAPRPGPA MAGPLSSCRL SARPEGGSGR GRRAERVSPS
RSNEVISPEI LKMRAALFCI FTYLDTRTLL HAAEVCRDWR FVARHPAVWT RVLLENARVC
SKFLAMLAQW CTQAHSLTLQ NLKPRQRGKK ESKEEYARST RGCLEAGLES LLKAAGGNLL
ILRISHCPNI LTDRSLWLAS CYCRALQAVT YRSATDPVGH EVIWALGAGC REIVSLQVAP
LHPCQQPTRF SNRCLQMIGR CWPHLRALGV GGAGCGVQGL ASLARNCMRL QVLELDHVSE
ITQEVAAEVC REGLKGLEML VLTATPVTPK ALLHFNSICR NLKSIVVQIG IADYFKEPSS
PEAQKLFEDM VTKLQALRRR PGFSKILHIK VEGGC
