FBX41_MOUSE
ID FBX41_MOUSE Reviewed; 873 AA.
AC Q6NS60; Q6P7W4; Q6ZPG1;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=F-box only protein 41;
GN Name=Fbxo41; Synonyms=D6Ertd538e, Kiaa1940;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-873.
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=16452087; DOI=10.1074/mcp.t500041-mcp200;
RA Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.;
RT "Comprehensive identification of phosphorylation sites in postsynaptic
RT density preparations.";
RL Mol. Cell. Proteomics 5:914-922(2006).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476; THR-477 AND SER-760, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-358, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Directly interacts with SKP1 and CUL1. {ECO:0000250}.
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DR EMBL; BC061475; AAH61475.1; -; mRNA.
DR EMBL; BC070445; AAH70445.1; -; mRNA.
DR EMBL; AK129466; BAC98276.1; -; mRNA.
DR CCDS; CCDS20296.1; -.
DR RefSeq; NP_001001160.1; NM_001001160.3.
DR RefSeq; NP_001276603.1; NM_001289674.1.
DR RefSeq; NP_001276604.1; NM_001289675.1.
DR AlphaFoldDB; Q6NS60; -.
DR SMR; Q6NS60; -.
DR BioGRID; 236950; 9.
DR IntAct; Q6NS60; 4.
DR MINT; Q6NS60; -.
DR STRING; 10090.ENSMUSP00000124754; -.
DR iPTMnet; Q6NS60; -.
DR PhosphoSitePlus; Q6NS60; -.
DR SwissPalm; Q6NS60; -.
DR MaxQB; Q6NS60; -.
DR PaxDb; Q6NS60; -.
DR PRIDE; Q6NS60; -.
DR ProteomicsDB; 271676; -.
DR Antibodypedia; 65168; 58 antibodies from 19 providers.
DR DNASU; 330369; -.
DR Ensembl; ENSMUST00000159062; ENSMUSP00000125671; ENSMUSG00000047013.
DR Ensembl; ENSMUST00000161078; ENSMUSP00000124524; ENSMUSG00000047013.
DR Ensembl; ENSMUST00000161546; ENSMUSP00000124754; ENSMUSG00000047013.
DR GeneID; 330369; -.
DR KEGG; mmu:330369; -.
DR UCSC; uc009cpw.2; mouse.
DR CTD; 150726; -.
DR MGI; MGI:1261912; Fbxo41.
DR VEuPathDB; HostDB:ENSMUSG00000047013; -.
DR eggNOG; KOG4341; Eukaryota.
DR GeneTree; ENSGT00530000063713; -.
DR HOGENOM; CLU_018140_0_0_1; -.
DR InParanoid; Q6NS60; -.
DR OMA; HFPCREL; -.
DR OrthoDB; 236860at2759; -.
DR PhylomeDB; Q6NS60; -.
DR TreeFam; TF329439; -.
DR Reactome; R-MMU-8951664; Neddylation.
DR Reactome; R-MMU-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR BioGRID-ORCS; 330369; 2 hits in 77 CRISPR screens.
DR PRO; PR:Q6NS60; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q6NS60; protein.
DR Bgee; ENSMUSG00000047013; Expressed in lateral septal nucleus and 90 other tissues.
DR ExpressionAtlas; Q6NS60; baseline and differential.
DR Genevisible; Q6NS60; MM.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR032675; LRR_dom_sf.
DR Pfam; PF12937; F-box-like; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Methylation; Phosphoprotein; Reference proteome;
KW Ubl conjugation pathway.
FT CHAIN 1..873
FT /note="F-box only protein 41"
FT /id="PRO_0000119941"
FT DOMAIN 548..592
FT /note="F-box"
FT REGION 85..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 207..349
FT /evidence="ECO:0000255"
FT COMPBIAS 168..184
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 439..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 471..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 358
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 476
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 477
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 760
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 873 AA; 94331 MW; 2B1BA501527F9700 CRC64;
MASLDLPYRC PRCGEHKRFR SLSSLRAHLE YSHTYETLYI LSKTNSICDG AAAAAAAAAA
ASGFPLAPEP AALLAVPGAR REVFESTSFQ GKEQATGPSP AGPHLLHHHH HHAPLAHFPA
DLVPASLPCE ELAEPGLVPA ARYALREIEI PLGELFARKS VASSACSTPP PGPGPGPCSG
PSSASPASPS PADVAYEEGL ARLKIRALEK LEVDRRLERL SEEVEQKIAG QVGRLQAELE
RKAAELETAR QESARLGREK EELEERASEL SRQVDVSVEL LASLKQDLVH KEQELSRKQQ
EVVQIDQFLK ETAAREASAK LRLQQFIEEL LERADRAERQ LQVISSSCGS TPSASLGRGG
GGSASGPGVR GPGRMREHHA GSAVPSTYAV SRHGSSPSTG ASSRVPAASQ SSGCYDSDSL
ELPRPEEGPS EDSGPGGLGS RAQATNGGSE RSQAPRSSGL RRQAIQNWQR RPRRHSTEGE
EGDVSDVGSR TTESEAEGPS DVPRPGPAVA GPLNSCRLSA RPEGGSGRGR RVERGSPSRS
NEVISPEILK MRAALFCIFT YLDTRTLLHA AEVCRDWRFV ARHPAVWTRV LLENARVCSK
FLAMLAQWCT QAHSLTLQNL KPRQRGKKES KEEYARSTRG CLEAGLESLL KAAGGNLLIL
RISHCPNILT DRSLWLASCY CRALQAVTYR SATDPVGHEV IWALGAGCRD IVSLQVAPLH
PCQQPTRFSN RCLQMIGRCW PHLRALGVGG AGCGVQGLAS LARNCMRLQV LELDHVSEIT
QEVAAEVCRE GLKGLEMLVL TATPVTPKAL LHFNSICRNL KSIVVQIGIA DYFKEPSSPE
AQKLFEDMVT KLQALRRRPG FSKILHIKVE GGC
