FBX42_MOUSE
ID FBX42_MOUSE Reviewed; 717 AA.
AC Q6PDJ6; A2A824; Q8CE76; Q99KY2;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=F-box only protein 42;
GN Name=Fbxo42;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-365; SER-373 AND SER-552, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. Specifically recognizes
CC p53/TP53, promoting its ubiquitination and degradation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of some SCF complex, composed of CUL1, SKP1, RBX1
CC and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction
CC is direct (By similarity). {ECO:0000250}.
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DR EMBL; AK028867; BAC26160.1; -; mRNA.
DR EMBL; AL607087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC003960; AAH03960.1; -; mRNA.
DR EMBL; BC058667; AAH58667.1; -; mRNA.
DR CCDS; CCDS18866.1; -.
DR RefSeq; NP_766106.2; NM_172518.3.
DR AlphaFoldDB; Q6PDJ6; -.
DR SMR; Q6PDJ6; -.
DR BioGRID; 229445; 1.
DR STRING; 10090.ENSMUSP00000030757; -.
DR iPTMnet; Q6PDJ6; -.
DR PhosphoSitePlus; Q6PDJ6; -.
DR EPD; Q6PDJ6; -.
DR MaxQB; Q6PDJ6; -.
DR PaxDb; Q6PDJ6; -.
DR PRIDE; Q6PDJ6; -.
DR ProteomicsDB; 271677; -.
DR Antibodypedia; 14535; 325 antibodies from 21 providers.
DR DNASU; 213499; -.
DR Ensembl; ENSMUST00000030757; ENSMUSP00000030757; ENSMUSG00000028920.
DR GeneID; 213499; -.
DR KEGG; mmu:213499; -.
DR UCSC; uc008vnz.2; mouse.
DR CTD; 54455; -.
DR MGI; MGI:1924992; Fbxo42.
DR VEuPathDB; HostDB:ENSMUSG00000028920; -.
DR eggNOG; KOG0379; Eukaryota.
DR GeneTree; ENSGT00440000039706; -.
DR HOGENOM; CLU_023579_0_0_1; -.
DR InParanoid; Q6PDJ6; -.
DR OMA; EGCDLKM; -.
DR OrthoDB; 838833at2759; -.
DR PhylomeDB; Q6PDJ6; -.
DR TreeFam; TF324505; -.
DR BioGRID-ORCS; 213499; 8 hits in 73 CRISPR screens.
DR ChiTaRS; Fbxo42; mouse.
DR PRO; PR:Q6PDJ6; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q6PDJ6; protein.
DR Bgee; ENSMUSG00000028920; Expressed in lumbar dorsal root ganglion and 233 other tissues.
DR Genevisible; Q6PDJ6; MM.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IBA:GO_Central.
DR Gene3D; 2.120.10.80; -; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF117281; SSF117281; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 1: Evidence at protein level;
KW Kelch repeat; Phosphoprotein; Reference proteome; Repeat;
KW Ubl conjugation pathway.
FT CHAIN 1..717
FT /note="F-box only protein 42"
FT /id="PRO_0000119943"
FT DOMAIN 44..93
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REPEAT 132..184
FT /note="Kelch 1"
FT REPEAT 186..242
FT /note="Kelch 2"
FT REPEAT 244..293
FT /note="Kelch 3"
FT REPEAT 295..342
FT /note="Kelch 4"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 570..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..426
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..602
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 365
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 373
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 378
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6P3S6"
FT MOD_RES 552
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT CONFLICT 48
FT /note="S -> Y (in Ref. 1; BAC26160)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="I -> T (in Ref. 3; AAH03960)"
FT /evidence="ECO:0000305"
FT CONFLICT 602
FT /note="S -> P (in Ref. 3; AAH03960)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 717 AA; 77777 MW; 0CE982C850704CDB CRC64;
MASSSDSEDD SVMAVDQEET ALEGTMEQDE DPHPVLEVEE TRHNRSMSEL PEEVLEYILS
FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG NIQWESRTYP YPGTPITQRF
SHSACYYDAN QSMYVFGGCT QSSCNAAFND LWRLDLNSKE WIRPLASGSY PSPKAGATLV
VYKDLLVLFG GWTRPSPYPL HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI
GDKMIVFGGS LGSRQMSNEV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDTTLLILG
GCGGPNALFK DAWLLHMHPG PWAWQPLKVE NEDHGAPELW CHPACRVGQC VVVFSQAPSG
RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE APCVNGRWGT LRPRAQRQTP
SGSREGSLSP ARGDGSPILN GGNLSPGTVA VGGASLDSPV QVVSPSTPSA SDGYDLKVGL
SLAPRRGSLP DQKDLRLSSI DLNWDLKSAS SSSHVDSIDN RTVAGSVRHP PEQTNGVHTP
PHVASALAGA VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPSSPGS QSLSSGETVP
NSRPGPAQGD GHSLPPIARR LGHHPPQSLN VGKPLYQSMN CKPMQMYVLD IKDTKEKGRV
KWKVFTSSSV VGPPETSLHT VVQGRGELIV FGGLMDKKQN VKYYPKTNAL YFVRAKR
