ID   FBX42_PONAB             Reviewed;         717 AA.
AC   Q5RDA9;
DT   15-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=F-box only protein 42;
GN   Name=FBXO42;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. Specifically recognizes
CC       p53/TP53, promoting its ubiquitination and degradation (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Component of some SCF complex, composed of CUL1, SKP1, RBX1
CC       and FBXO42. Interacts (via the kelch domain) with p53/TP53; interaction
CC       is direct (By similarity). {ECO:0000250}.
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DR   EMBL; CR858005; CAH90248.1; -; mRNA.
DR   RefSeq; NP_001125106.1; NM_001131634.1.
DR   AlphaFoldDB; Q5RDA9; -.
DR   SMR; Q5RDA9; -.
DR   STRING; 9601.ENSPPYP00000002116; -.
DR   GeneID; 100171988; -.
DR   KEGG; pon:100171988; -.
DR   CTD; 54455; -.
DR   eggNOG; KOG0379; Eukaryota.
DR   InParanoid; Q5RDA9; -.
DR   Proteomes; UP000001595; Unplaced.
DR   Gene3D; 2.120.10.80; -; 1.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF117281; SSF117281; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Kelch repeat; Phosphoprotein; Reference proteome; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..717
FT                   /note="F-box only protein 42"
FT                   /id="PRO_0000119944"
FT   DOMAIN          44..93
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REPEAT          132..184
FT                   /note="Kelch 1"
FT   REPEAT          186..242
FT                   /note="Kelch 2"
FT   REPEAT          244..293
FT                   /note="Kelch 3"
FT   REPEAT          295..342
FT                   /note="Kelch 4"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..539
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          570..635
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..47
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..376
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..426
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        441..468
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..598
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         365
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P3S6"
FT   MOD_RES         373
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P3S6"
FT   MOD_RES         378
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P3S6"
FT   MOD_RES         552
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6P3S6"
SQ   SEQUENCE   717 AA;  77800 MW;  DB6AEBAE557A4A4F CRC64;
     MASSSDSEDD SFMAVDQEET VLEGTMEQDE EPHPVLEAEE TRHNRSMSEL PEEVLEYILS
     FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFVKAVQEG NIQWESRTYP YPGTPITQRF
     SHSACYYDAN QSMYVFGGCT QSSCNAAFND LWRLDLNSKE WIRPLASGSY PSPKAGATLV
     VYKDLLVLFG GWTRPSPYPL HQPERFFDEI HTYSPSKNWW NCIVTTHGPP PMAGHSSCVI
     DDKMIVFGGS LGSRQMSNDV WVLDLEQWAW SKPNISGPSP HPRGGQSQIV IDDATILILG
     GCGGPNALFK DAWLLHMHSG PWAWQPLKVE NEEHGAPELW CHPACRVGQC VVVFSQAPSG
     RAPLSPSLNS RPSPISATPP ALVPETREYR SQSPVRSMDE APCVNGRWGT LRPRAQRQTP
     SGSREGSLSP ARGDGSPILN GGSLSPGTAA VGGSSLDSPV QAISPSTPSA AEGYDLKIGL
     SLAPRRGSLP DQKDLRLGSV DLNWDLKPAS SSNPMDGMDN RTVGGSMRHP PEQTNGVHTP
     PHVASALAGA VSPGALRRSL EAIKAMSSKG PSASAALSPP LGSSPGSPGS QSLSSGETVP
     IPRPGPAQGD GHSLPPIARR LGRHPPQSLN VGKPLYQSMN CKPMQMYVLD IKDTKEKGRV
     KWKVFNSSSV VGPPETSLHT VVQGRGELII FGGLMDKKQN VKYYPKTNAL YFVRAKR