FBX46_MOUSE
ID FBX46_MOUSE Reviewed; 603 AA.
AC Q8BG80;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=F-box only protein 46;
DE AltName: Full=F-box only protein 34-like;
GN Name=Fbxo46; Synonyms=Fbx46, Fbxo34l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Limb;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR EMBL; AK030147; BAC26809.1; -; mRNA.
DR EMBL; AK030220; BAC26851.1; -; mRNA.
DR EMBL; BC049813; AAH49813.1; -; mRNA.
DR CCDS; CCDS20890.1; -.
DR RefSeq; NP_780739.1; NM_175530.3.
DR RefSeq; XP_006539998.1; XM_006539935.2.
DR RefSeq; XP_006539999.1; XM_006539936.2.
DR RefSeq; XP_006540000.1; XM_006539937.3.
DR AlphaFoldDB; Q8BG80; -.
DR BioGRID; 232572; 1.
DR STRING; 10090.ENSMUSP00000055692; -.
DR iPTMnet; Q8BG80; -.
DR PhosphoSitePlus; Q8BG80; -.
DR EPD; Q8BG80; -.
DR jPOST; Q8BG80; -.
DR MaxQB; Q8BG80; -.
DR PaxDb; Q8BG80; -.
DR PeptideAtlas; Q8BG80; -.
DR PRIDE; Q8BG80; -.
DR ProteomicsDB; 267354; -.
DR Antibodypedia; 31380; 73 antibodies from 14 providers.
DR Ensembl; ENSMUST00000053109; ENSMUSP00000055692; ENSMUSG00000050428.
DR Ensembl; ENSMUST00000165913; ENSMUSP00000129427; ENSMUSG00000050428.
DR GeneID; 243867; -.
DR KEGG; mmu:243867; -.
DR UCSC; uc009fkt.2; mouse.
DR CTD; 23403; -.
DR MGI; MGI:2444918; Fbxo46.
DR VEuPathDB; HostDB:ENSMUSG00000050428; -.
DR eggNOG; KOG4564; Eukaryota.
DR GeneTree; ENSGT00530000064222; -.
DR HOGENOM; CLU_028677_0_0_1; -.
DR InParanoid; Q8BG80; -.
DR OMA; WNRDPLY; -.
DR OrthoDB; 329015at2759; -.
DR PhylomeDB; Q8BG80; -.
DR TreeFam; TF331673; -.
DR BioGRID-ORCS; 243867; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q8BG80; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BG80; protein.
DR Bgee; ENSMUSG00000050428; Expressed in granulocyte and 105 other tissues.
DR Genevisible; Q8BG80; MM.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR039594; FBXO34/46.
DR PANTHER; PTHR16271; PTHR16271; 1.
DR Pfam; PF12937; F-box-like; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..603
FT /note="F-box only protein 46"
FT /id="PRO_0000119951"
FT DOMAIN 470..522
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT REGION 18..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..141
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..255
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..358
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..430
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 347
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6PJ61"
SQ SEQUENCE 603 AA; 65294 MW; B8B6AF154D1BAD5E CRC64;
MDRGSLLPFQ LWCPRPFSKY SQNQPRPPST ALKPPVCPDT SSGTEPDHRP AHLESTPPAV
AAEAPTSQPA PLLSTAASGD EGRVLLDTWY VIKPGNTKEK VAFFVAHQCG GSSRASSMKV
KGHWGSDSSK AKRRRRCLEP TKAPPDQGGR EGTPATEVTP TSSGDDVDLV SVAEMVALVE
QRAALALQSY PRPSTPAPVV FVSADQGGPA KGLGSERRSG GGDCSRVAEA VAHFEAQRDS
PPTKGLRKEE RPGPGPGEVR IAFRISNVRE PHSPDGNLPN GGGGRPGCAY PGSPGPGTRA
KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGETPA PTRPEDTPPA PPPPPARDCG
ASGFHVDVVV TGVVDACIFF GKDGTKNVKE ETVCLTVSPE EPPPPGQLFF LQSRGPEGPP
EPPPADIPST VPGPDDSEGT TDTSLCRLYR HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV
LVKIFSFLPT RALAALKCTC HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG
DVSLCRWHPK PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GVGGGRAGRE
EGR
