ID   FBX46_RAT               Reviewed;         603 AA.
AC   Q4KLY2;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=F-box only protein 46;
GN   Name=Fbxo46;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box
CC       protein)-type E3 ubiquitin ligase complex. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SKP1 and CUL1. {ECO:0000250}.
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DR   EMBL; BC098945; AAH98945.1; -; mRNA.
DR   RefSeq; NP_001020813.1; NM_001025642.1.
DR   RefSeq; XP_006228461.1; XM_006228399.3.
DR   RefSeq; XP_006228462.1; XM_006228400.3.
DR   RefSeq; XP_006228463.1; XM_006228401.3.
DR   RefSeq; XP_008757132.1; XM_008758910.2.
DR   RefSeq; XP_017444383.1; XM_017588894.1.
DR   AlphaFoldDB; Q4KLY2; -.
DR   STRING; 10116.ENSRNOP00000012082; -.
DR   PhosphoSitePlus; Q4KLY2; -.
DR   PaxDb; Q4KLY2; -.
DR   Ensembl; ENSRNOT00000012082; ENSRNOP00000012082; ENSRNOG00000008815.
DR   Ensembl; ENSRNOT00000111723; ENSRNOP00000081250; ENSRNOG00000008815.
DR   Ensembl; ENSRNOT00000115550; ENSRNOP00000090659; ENSRNOG00000008815.
DR   Ensembl; ENSRNOT00000118710; ENSRNOP00000079832; ENSRNOG00000008815.
DR   Ensembl; ENSRNOT00000119270; ENSRNOP00000097011; ENSRNOG00000008815.
DR   GeneID; 292686; -.
DR   KEGG; rno:292686; -.
DR   UCSC; RGD:1308393; rat.
DR   CTD; 23403; -.
DR   RGD; 1308393; Fbxo46.
DR   eggNOG; KOG4564; Eukaryota.
DR   GeneTree; ENSGT00530000064222; -.
DR   HOGENOM; CLU_028677_0_0_1; -.
DR   InParanoid; Q4KLY2; -.
DR   OMA; WNRDPLY; -.
DR   OrthoDB; 329015at2759; -.
DR   PhylomeDB; Q4KLY2; -.
DR   TreeFam; TF331673; -.
DR   PRO; PR:Q4KLY2; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000008815; Expressed in testis and 19 other tissues.
DR   Genevisible; Q4KLY2; RN.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR039594; FBXO34/46.
DR   PANTHER; PTHR16271; PTHR16271; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..603
FT                   /note="F-box only protein 46"
FT                   /id="PRO_0000239737"
FT   DOMAIN          470..522
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REGION          20..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..163
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          235..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          332..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..442
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..141
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..255
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..358
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         347
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q6PJ61"
SQ   SEQUENCE   603 AA;  65239 MW;  E11F541FFDB8751B CRC64;
     MDRGSLLPFQ LWCPRPFSKY SQNQPRPPSA TLKPPVCPDT SSGTEPDHRP AHLESTPPAL
     AAEAPTSQHA PLLSTAASGD EGRVLLDTWY VIKPGNTKEK VAFFVAHQCG GGSRASSMKV
     KGHWGSDSSK AKRRRRCLEP TKAPPDQGGQ EGTPATEVAP TSSGDDVDLL SVAEMVALVE
     QRAALALQSY PRPSTPAPVV FVSAEQGGPA KGLGSERRSG GGDCSRVAEA VAHFEAQRDS
     PPTKGLRKEE RPGPGPGEVR IAFRISNVRE PQSPDGSLAN GGGGRPACPY PGSPGPGTRA
     KDKITCDLYQ LISPSRDALP SNVEFLLARA DEASEGETPA PARPEDTPPA PPPPPARDCG
     ASGFHVDVVV TGVVDACIFF GKDGTKNVKE ETVCLTVSPE EPPPPGQLFF LQSRGPEGPP
     EPPPADTASK VPGPEDSEGT TDTSLCRLYR HVSHDFLEIR FKIQRLLEPR QYMLLLPEHV
     LVKIFSFLPT RALAALKCTC HHFKGIIEAF GVRATDSRWS RDPLYRDDPC KQCRKRYEKG
     DVSLCRWHPK PYHHDLPYGR SYWMCCRRAD RETPGCRLGL HDNNWVLPCN GVGGGRAGRE
     EGR