FBX47_MOUSE
ID FBX47_MOUSE Reviewed; 451 AA.
AC A2A6H3; B2RY07;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=F-box only protein 47;
GN Name=Fbxo47;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably recognizes and binds to some phosphorylated proteins
CC and promotes their ubiquitination and degradation. {ECO:0000250}.
CC -!- SUBUNIT: Part of a SCF (SKP1-cullin-F-box) protein ligase complex.
CC {ECO:0000250}.
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DR EMBL; AL596446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC158049; AAI58050.1; -; mRNA.
DR CCDS; CCDS36299.1; -.
DR RefSeq; NP_001074904.1; NM_001081435.1.
DR RefSeq; XP_006534391.1; XM_006534328.3.
DR RefSeq; XP_006534392.1; XM_006534329.3.
DR RefSeq; XP_006534393.1; XM_006534330.3.
DR AlphaFoldDB; A2A6H3; -.
DR BioGRID; 215685; 2.
DR STRING; 10090.ENSMUSP00000091471; -.
DR iPTMnet; A2A6H3; -.
DR PhosphoSitePlus; A2A6H3; -.
DR PaxDb; A2A6H3; -.
DR PRIDE; A2A6H3; -.
DR Antibodypedia; 65659; 66 antibodies from 14 providers.
DR Ensembl; ENSMUST00000093939; ENSMUSP00000091471; ENSMUSG00000070336.
DR GeneID; 72973; -.
DR KEGG; mmu:72973; -.
DR UCSC; uc007lfb.1; mouse.
DR CTD; 494188; -.
DR MGI; MGI:1920223; Fbxo47.
DR VEuPathDB; HostDB:ENSMUSG00000070336; -.
DR eggNOG; ENOG502QV8T; Eukaryota.
DR GeneTree; ENSGT00390000014175; -.
DR HOGENOM; CLU_048746_0_0_1; -.
DR InParanoid; A2A6H3; -.
DR OMA; PWPLVSQ; -.
DR OrthoDB; 803884at2759; -.
DR PhylomeDB; A2A6H3; -.
DR TreeFam; TF343134; -.
DR BioGRID-ORCS; 72973; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Fbxo47; mouse.
DR PRO; PR:A2A6H3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2A6H3; protein.
DR Bgee; ENSMUSG00000070336; Expressed in spermatid and 51 other tissues.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR038946; FBXO47.
DR PANTHER; PTHR34098; PTHR34098; 1.
DR Pfam; PF00646; F-box; 1.
DR SUPFAM; SSF81383; SSF81383; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..451
FT /note="F-box only protein 47"
FT /id="PRO_0000307726"
FT DOMAIN 41..91
FT /note="F-box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
SQ SEQUENCE 451 AA; 51374 MW; 4DD1A55803102DE6 CRC64;
MASRVNTSFT LIPKQKCRRS NHHSSYFCNT LDSDPQLLST LGNFKVLPLE ILHIILRYLS
VKDIGMLSMV SKTVSQHIIN YISTSSGSRR LLLQNFHDLD LPGTKEETAL LEHYRALGLL
FKRCTLLLPT KERLKYIHKI LSEVSCFKFS GCSVPLQCLG LSCYGMFLQT LTAGWDELEC
HRVYNFLCEL TNLSRKMQTV VCNKPGSARK LELRVRLFCR NVLLDHWTHR SDSAFWLTRI
LKPWPMVNQA RLLYIIFGPT SPHDGQVIWQ EMIEGPTDES SLKGLANAIK LLYDTGAKGW
TADDVISLVD ELSVVPREWL LENNARLLIL SGNNICFTFM ASKAVNGRAV ELARLVVFLA
LVCEKELYCM DWTVRMMQKV CKVFSTAAER KSFLQSIANA FACVTMEMLQ PVMSGDRDDD
DRGFLNLFHL LHAQANFHKE VLYLTMNAIS S