ID   FBX48_HUMAN             Reviewed;         155 AA.
AC   Q5FWF7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=F-box only protein 48;
GN   Name=FBXO48; Synonyms=FBX48;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Corcoran M.M., Cepeda D., Akhondi S., Spruck C., Sangfelt O.;
RT   "Identification of human F-box only 48 (FBXO48).";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lymph;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- INTERACTION:
CC       Q5FWF7; P63208: SKP1; NbExp=5; IntAct=EBI-11961122, EBI-307486;
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DR   EMBL; DQ904332; ABI98402.1; -; mRNA.
DR   EMBL; BC089423; AAH89423.1; -; mRNA.
DR   CCDS; CCDS33213.1; -.
DR   RefSeq; NP_001019851.1; NM_001024680.2.
DR   RefSeq; XP_005264464.1; XM_005264407.2.
DR   RefSeq; XP_016859926.1; XM_017004437.1.
DR   AlphaFoldDB; Q5FWF7; -.
DR   BioGRID; 299847; 4.
DR   IntAct; Q5FWF7; 1.
DR   STRING; 9606.ENSP00000367193; -.
DR   iPTMnet; Q5FWF7; -.
DR   PhosphoSitePlus; Q5FWF7; -.
DR   BioMuta; FBXO48; -.
DR   DMDM; 74755340; -.
DR   MassIVE; Q5FWF7; -.
DR   MaxQB; Q5FWF7; -.
DR   PaxDb; Q5FWF7; -.
DR   PeptideAtlas; Q5FWF7; -.
DR   PRIDE; Q5FWF7; -.
DR   ProteomicsDB; 62818; -.
DR   Antibodypedia; 63770; 45 antibodies from 7 providers.
DR   DNASU; 554251; -.
DR   Ensembl; ENST00000377957.4; ENSP00000367193.2; ENSG00000204923.4.
DR   GeneID; 554251; -.
DR   KEGG; hsa:554251; -.
DR   MANE-Select; ENST00000377957.4; ENSP00000367193.2; NM_001024680.3; NP_001019851.1.
DR   UCSC; uc002seo.5; human.
DR   CTD; 554251; -.
DR   DisGeNET; 554251; -.
DR   GeneCards; FBXO48; -.
DR   HGNC; HGNC:33857; FBXO48.
DR   HPA; ENSG00000204923; Low tissue specificity.
DR   neXtProt; NX_Q5FWF7; -.
DR   OpenTargets; ENSG00000204923; -.
DR   PharmGKB; PA162388158; -.
DR   VEuPathDB; HostDB:ENSG00000204923; -.
DR   eggNOG; ENOG502S15Z; Eukaryota.
DR   GeneTree; ENSGT00390000012248; -.
DR   HOGENOM; CLU_143592_0_0_1; -.
DR   InParanoid; Q5FWF7; -.
DR   OMA; KRDWLRG; -.
DR   OrthoDB; 1382647at2759; -.
DR   PhylomeDB; Q5FWF7; -.
DR   TreeFam; TF332573; -.
DR   PathwayCommons; Q5FWF7; -.
DR   SignaLink; Q5FWF7; -.
DR   BioGRID-ORCS; 554251; 9 hits in 1073 CRISPR screens.
DR   ChiTaRS; FBXO48; human.
DR   GenomeRNAi; 554251; -.
DR   Pharos; Q5FWF7; Tdark.
DR   PRO; PR:Q5FWF7; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; Q5FWF7; protein.
DR   Bgee; ENSG00000204923; Expressed in thymus and 107 other tissues.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR045118; FBXO9/FBXO48.
DR   PANTHER; PTHR12874; PTHR12874; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..155
FT                   /note="F-box only protein 48"
FT                   /id="PRO_0000335677"
FT   DOMAIN          32..79
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         16
FT                   /note="T -> I (in dbSNP:rs12614904)"
FT                   /id="VAR_043466"
SQ   SEQUENCE   155 AA;  18241 MW;  135851156496E816 CRC64;
     MHKNSKRNNN LRVSHTEANS VDAEKEKNES QNNFFELLPA EITFKIFSQL DIRSLCRASL
     TCRSWNDTIR NSDSLWKPHC MTVRAVCRRE IDDDLESGYS WRVILLRNYQ KSKVKHEWLS
     GRYSNICSPI SLPEKIMYPM DADTWGEILE AELER