ID   FBX48_MOUSE             Reviewed;         161 AA.
AC   Q8CAT8; Q8C9J8;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=F-box only protein 48;
GN   Name=Fbxo48; Synonyms=Fbx48;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Thymus;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; AK037835; BAC29883.1; -; mRNA.
DR   EMBL; AK041978; BAC31118.1; -; mRNA.
DR   EMBL; AL645532; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC125589; AAI25590.1; -; mRNA.
DR   EMBL; BC125591; AAI25592.1; -; mRNA.
DR   CCDS; CCDS24445.1; -.
DR   RefSeq; NP_795956.1; NM_176982.2.
DR   RefSeq; XP_006514791.1; XM_006514728.3.
DR   RefSeq; XP_006514792.1; XM_006514729.3.
DR   RefSeq; XP_006514794.1; XM_006514731.3.
DR   RefSeq; XP_006514795.1; XM_006514732.3.
DR   RefSeq; XP_011242028.1; XM_011243726.2.
DR   RefSeq; XP_017170091.1; XM_017314602.1.
DR   RefSeq; XP_017170092.1; XM_017314603.1.
DR   RefSeq; XP_017170093.1; XM_017314604.1.
DR   AlphaFoldDB; Q8CAT8; -.
DR   STRING; 10090.ENSMUSP00000057901; -.
DR   PaxDb; Q8CAT8; -.
DR   PRIDE; Q8CAT8; -.
DR   Antibodypedia; 63770; 45 antibodies from 7 providers.
DR   Ensembl; ENSMUST00000061327; ENSMUSP00000057901; ENSMUSG00000044966.
DR   Ensembl; ENSMUST00000109635; ENSMUSP00000105263; ENSMUSG00000044966.
DR   GeneID; 319701; -.
DR   KEGG; mmu:319701; -.
DR   UCSC; uc007ibt.1; mouse.
DR   CTD; 554251; -.
DR   MGI; MGI:2442569; Fbxo48.
DR   VEuPathDB; HostDB:ENSMUSG00000044966; -.
DR   eggNOG; ENOG502S15Z; Eukaryota.
DR   GeneTree; ENSGT00390000012248; -.
DR   HOGENOM; CLU_143592_0_0_1; -.
DR   InParanoid; Q8CAT8; -.
DR   OMA; KRDWLRG; -.
DR   OrthoDB; 1382647at2759; -.
DR   PhylomeDB; Q8CAT8; -.
DR   TreeFam; TF332573; -.
DR   BioGRID-ORCS; 319701; 1 hit in 72 CRISPR screens.
DR   PRO; PR:Q8CAT8; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8CAT8; protein.
DR   Bgee; ENSMUSG00000044966; Expressed in morula and 54 other tissues.
DR   GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR   GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR036047; F-box-like_dom_sf.
DR   InterPro; IPR001810; F-box_dom.
DR   InterPro; IPR045118; FBXO9/FBXO48.
DR   PANTHER; PTHR12874; PTHR12874; 1.
DR   Pfam; PF12937; F-box-like; 1.
DR   SMART; SM00256; FBOX; 1.
DR   SUPFAM; SSF81383; SSF81383; 1.
DR   PROSITE; PS50181; FBOX; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..161
FT                   /note="F-box only protein 48"
FT                   /id="PRO_0000335678"
FT   DOMAIN          32..79
FT                   /note="F-box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00080"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        79
FT                   /note="H -> N (in Ref. 1; BAC31118)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   161 AA;  18762 MW;  509BABA788AA02F0 CRC64;
     MKKTSKKNNN FKIPGTELNS ADAERGKEES QRNFVELLPL EVTYKIFSQL DIQSLCRASR
     TCTGWNCAIR NNDSLWKPHC LTIRAVCQRE IDDDIKSGYT WRVILLRNYQ KSKVKYEWLS
     GRYSNIRSPV NLPEKAMCPM DADTWGEILD AELEREVEKL Q