FBX50_DANRE
ID FBX50_DANRE Reviewed; 237 AA.
AC Q568V3; A1L1Z5; A2BHA4; Q3B7F3; Q9PTD8;
DT 06-MAR-2013, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=F-box only protein 50;
DE AltName: Full=NCC receptor protein 1;
DE Short=NCCRP-1;
DE AltName: Full=Non-specific cytotoxic cell receptor protein 1;
GN Name=nccrp1; ORFNames=si:dkey-85K8.6, wu:fa93e02, wu:fb12f07, zgc:122987;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11847564; DOI=10.1007/s00239-001-0027-8;
RA Jaso-Friedmann L., Peterson D.S., Gonzalez D.S., Evans D.L.;
RT "The antigen receptor (NCCRP-1) on catfish and zebrafish nonspecific
RT cytotoxic cells belongs to a new gene family characterized by an F-box-
RT associated domain.";
RL J. Mol. Evol. 54:386-395(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gill, Olfactory epithelium, and Ovary;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=19477195; DOI=10.1016/j.dci.2009.05.009;
RA Moss L.D., Monette M.M., Jaso-Friedmann L., Leary J.H. III, Dougan S.T.,
RA Krunkosky T., Evans D.L.;
RT "Identification of phagocytic cells, NK-like cytotoxic cell activity and
RT the production of cellular exudates in the coelomic cavity of adult
RT zebrafish.";
RL Dev. Comp. Immunol. 33:1077-1087(2009).
CC -!- FUNCTION: May promote cell proliferation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in nonspecific cytotoxic cells (NCC).
CC {ECO:0000269|PubMed:19477195}.
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DR EMBL; AF207707; AAF19642.1; -; mRNA.
DR EMBL; BX547938; CAM16435.1; -; Genomic_DNA.
DR EMBL; BC092704; AAH92704.2; -; mRNA.
DR EMBL; BC107632; AAI07633.1; -; mRNA.
DR EMBL; BC129278; AAI29279.1; -; mRNA.
DR RefSeq; NP_570996.2; NM_130921.2.
DR AlphaFoldDB; Q568V3; -.
DR SMR; Q568V3; -.
DR STRING; 7955.ENSDARP00000051185; -.
DR PaxDb; Q568V3; -.
DR DNASU; 30078; -.
DR Ensembl; ENSDART00000051186; ENSDARP00000051185; ENSDARG00000035326.
DR Ensembl; ENSDART00000186667; ENSDARP00000147799; ENSDARG00000113175.
DR GeneID; 30078; -.
DR KEGG; dre:30078; -.
DR CTD; 342897; -.
DR ZFIN; ZDB-GENE-000210-13; nccrp1.
DR eggNOG; KOG3248; Eukaryota.
DR GeneTree; ENSGT00940000161313; -.
DR HOGENOM; CLU_068548_0_0_1; -.
DR InParanoid; Q568V3; -.
DR OMA; DGDFSGW; -.
DR OrthoDB; 922544at2759; -.
DR PhylomeDB; Q568V3; -.
DR TreeFam; TF320527; -.
DR PRO; PR:Q568V3; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 5.
DR Bgee; ENSDARG00000035326; Expressed in granulocyte and 24 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
DR GO; GO:0006516; P:glycoprotein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IEA:GOC.
DR GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR GO; GO:0030433; P:ubiquitin-dependent ERAD pathway; IBA:GO_Central.
DR InterPro; IPR007397; F-box-assoc_dom.
DR InterPro; IPR039752; F-box_only.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR PANTHER; PTHR12125; PTHR12125; 1.
DR Pfam; PF04300; FBA; 1.
DR SMART; SM01198; FBA; 1.
DR SUPFAM; SSF49785; SSF49785; 1.
DR PROSITE; PS51114; FBA; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..237
FT /note="F-box only protein 50"
FT /id="PRO_0000421451"
FT DOMAIN 31..231
FT /note="FBA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00482"
FT REGION 40..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..73
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 100
FT /note="G -> S (in Ref. 3; AAI29279)"
FT /evidence="ECO:0000305"
FT CONFLICT 113
FT /note="T -> S (in Ref. 3; AAI07633)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="T -> N (in Ref. 1; AAF19642)"
FT /evidence="ECO:0000305"
FT CONFLICT 197
FT /note="A -> G (in Ref. 1; AAF19642 and 3; AAI07633/
FT AAI29279)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="A -> T (in Ref. 1; AAF19642)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 237 AA; 27256 MW; 40BDAAA8CC3BC4A0 CRC64;
MATDWKQKCD SEWQLGAHGV PMPDTVDWKS VFETKPFERN LLQNPSPYGV NHTVPPPEPH
RSGIPPPSDR PPQLEPEGNF SGWKTNTEVL PYDTSGIPPG VVICQLPQHR WFTLEQCVDL
KAAGLWDQLL DDFQPEIVIE DWYEESQLHK CIYQLDVKLL GADGETVIKQ HTYNPEEDLE
CYSHTWKKVS HVFSKYAPGV RYIHFLHRLK NQFMVEFFNT KVTDSSVIVK ASKPSVK
